Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons

Nature ◽  
2005 ◽  
Vol 437 (7060) ◽  
pp. 898-901 ◽  
Author(s):  
Hiroko Kimoto ◽  
Sachiko Haga ◽  
Koji Sato ◽  
Kazushige Touhara
Keyword(s):  
Sensory Neurons ◽  
Exocrine Glands ◽  
Vomeronasal Sensory Neurons

scholarly journals Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons

2015 ◽  
Vol 212 (5) ◽  
pp. 2125OIA23
Author(s):  
Asma Amjad ◽  
Andres Hernandez-Clavijo ◽  
Simone Pifferi ◽  
Devendra Kumar Maurya ◽  
Anna Boccaccio ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Conditional Knockout ◽  
Chloride Current ◽  
Vomeronasal Sensory Neurons

Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides

2009 ◽  
Vol 12 (12) ◽  
pp. 1551-1558 ◽  
Author(s):  
Trese Leinders-Zufall ◽  
Tomohiro Ishii ◽  
Peter Mombaerts ◽  
Frank Zufall ◽  
Thomas Boehm
Keyword(s):  
Sensory Neurons ◽  
Structural Requirements ◽  
Vomeronasal Sensory Neurons

scholarly journals Estradiol rapidly modulates odor responses in mouse vomeronasal sensory neurons

Neuroscience ◽  
2014 ◽  
Vol 269 ◽  
pp. 43-58 ◽  
Author(s):  
S. Cherian ◽  
Y. Wai Lam ◽  
I. McDaniels ◽  
M. Struziak ◽  
R.J. Delay
Keyword(s):  
Sensory Neurons ◽  
Vomeronasal Sensory Neurons

scholarly journals Olfactory and Vomeronasal Receptor Feedback Employ Divergent Mechanisms of PERK Activation

2018 ◽  
Author(s):  
Ryan P Dalton ◽  
G Elif Karagöz ◽  
Jerome Kahiapo ◽  
Ruchira Sharma ◽  
Lisa E Bashkirova ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Transcription Factor ◽  
Sensory Neurons ◽  
Olfactory Receptor ◽  
Vomeronasal Receptor ◽  
Gene Regulatory ◽  
Lumenal Domain ◽  
Vomeronasal Sensory Neurons

AbstractMutually-exclusive chemoreceptor expression in olfactory and vomeronasal sensory neurons (OSNs and VSNs) enables odorant discrimination. This configuration involves chemoreceptor mediated activation of the endoplasmic reticulum (ER)-resident kinase PERK. PERK drives translation of the transcription factor ATF5 to preclude additional chemoreceptor expression. ATF5 translation is transient in OSNs but persistent in VSNs, suggesting chemoreceptor-specific modes of PERK activation. Herein, we showed that the ER-lumenal domain (LD) of PERK recognized vomeronasal receptor (VR)-derived peptides, suggesting direct PERK activation drives persistent ATF5 translation in VSNs. In contrast, PERK LD did not recognize olfactory receptor (OR)-derived peptides in vitro, and facilitating OR maturation in vivo prevented PERK activation, suggesting that ORs activate PERK indirectly through a failure to exit the ER. Importantly, impairing or prolonging ATF5 expression drove specific chemoreceptor repertoire biases. Together, these results demonstrate mechanistic divergence in chemoreceptor feedback and establish that differences in PERK activation promote qualitatively different gene regulatory results.

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