scholarly journals Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain

Nature ◽  
2004 ◽  
Vol 429 (6992) ◽  
pp. 671-675 ◽  
Author(s):  
Filip Van Petegem ◽  
Kimberly A. Clark ◽  
Franck C. Chatelain ◽  
Daniel L. Minor
Keyword(s):  
Calcium Channel ◽  
Β Subunit ◽  
Α Subunit ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel

scholarly journals Co-Silencing of the Voltage-Gated Calcium Channel β Subunit and High-Voltage Activated α1 Subunit by dsRNA Soaking Resulted in Enhanced Defects in Locomotion, Stylet Thrusting, Chemotaxis, Protein Secretion, and Reproduction in Ditylenchus destructor

2022 ◽  
Vol 23 (2) ◽  
pp. 784
Author(s):  
Mingwei An ◽  
Xueling Chen ◽  
Zhuhong Yang ◽  
Jianyu Zhou ◽  
Shan Ye ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Protein Secretion ◽  
High Voltage ◽  
Single Gene ◽  
Parasitic Nematodes ◽  
Β Subunit ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
Ditylenchus Destructor ◽  
Plant Parasitic

The voltage-gated calcium channel (VGCC) β subunit (Cavβ) protein is a kind of cytosolic auxiliary subunit that plays an important role in regulating the surface expression and gating characteristics of high-voltage-activated (HVA) calcium channels. Ditylenchus destructor is an important plant-parasitic nematode. In the present study, the putative Cavβ subunit gene of D. destructor, namely, DdCavβ, was subjected to molecular characterization. In situ hybridization assays showed that DdCavβ was expressed in all nematode tissues. Transcriptional analyses showed that DdCavβ was expressed during each developmental stage of D. destructor, and the highest expression level was recorded in the third-stage juveniles. The crucial role of DdCavβ was verified by dsRNA soaking-mediated RNA interference (RNAi). Silencing of DdCavβ or HVA Cavα1 alone and co-silencing of the DdCavβ and HVA Cavα1 genes resulted in defective locomotion, stylet thrusting, chemotaxis, protein secretion and reproduction in D. destructor. Co-silencing of the HVA Cavα1 and Cavβ subunits showed stronger interference effects than single-gene silencing. This study provides insights for further study of VGCCs in plant-parasitic nematodes.

The voltage-gated calcium-channel β subunit: more than just an accessory

2009 ◽  
Vol 39 (1) ◽  
pp. 75-81 ◽  
Author(s):  
Yamuna Karunasekara ◽  
Angela F. Dulhunty ◽  
Marco G. Casarotto
Keyword(s):  
Calcium Channel ◽  
Β Subunit ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel

scholarly journals Determinants for Membrane Targeting of Non-Palmitoylated Voltage-Gated Calcium Channel β-Subunit

2013 ◽  
Vol 104 (2) ◽  
pp. 462a
Author(s):  
Erick Miranda Laferte ◽  
David Ewers ◽  
Silke Schmidt ◽  
Patricia Hidalgo
Keyword(s):  
Calcium Channel ◽  
Membrane Targeting ◽  
Β Subunit ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel
Sign in / Sign up

Export Citation Format

Share Document