Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase

Nature ◽  
2002 ◽  
Vol 418 (6899) ◽  
pp. 793-797 ◽  
Author(s):  
Jiaxu Li ◽  
Toshinori Kinoshita ◽  
Sona Pandey ◽  
Carl K.-Y. Ng ◽  
Steven P. Gygi ◽  
...  
Keyword(s):  
Abscisic Acid ◽  
Protein Kinase ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

Expression of TAR RNA-Binding Protein in Baculovirus and Co-Immunoprecipitation with Insect Cell Protein Kinase

1995 ◽  
Vol 2 (4) ◽  
pp. 322-329
Author(s):  
Edward D. Blair ◽  
Christopher M. Roberts ◽  
Wendy B. Snowden ◽  
Anne Gatignol ◽  
Monsef Benkirange ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Insect Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cell Protein ◽  
Tar Rna

The RNA-binding protein FCA is an abscisic acid receptor

Nature ◽  
2006 ◽  
Vol 439 (7074) ◽  
pp. 290-294 ◽  
Author(s):  
Fawzi A. Razem ◽  
Ashraf El-Kereamy ◽  
Suzanne R. Abrams ◽  
Robert D. Hill
Keyword(s):  
Abscisic Acid ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Acid Receptor

scholarly journals Role of the RNA-binding Protein Nrd1 and Pmk1 Mitogen-activated Protein Kinase in the Regulation of Myosin mRNA Stability in Fission Yeast

2009 ◽  
Vol 20 (9) ◽  
pp. 2473-2485 ◽  
Author(s):  
Ryosuke Satoh ◽  
Takahiro Morita ◽  
Hirofumi Takada ◽  
Ayako Kita ◽  
Shunji Ishiwata ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Fission Yeast ◽  
Mrna Stability ◽  
Rna Binding ◽  
Binding Protein ◽  
Myosin Ii ◽  
Rna Binding Protein ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein

Myosin II is an essential component of the actomyosin contractile ring and plays a crucial role in cytokinesis by generating the forces necessary for contraction of the actomyosin ring. Cdc4 is an essential myosin II light chain in fission yeast and is required for cytokinesis. In various eukaryotes, the phosphorylation of myosin is well documented as a primary means of activating myosin II, but little is known about the regulatory mechanisms of Cdc4. Here, we isolated Nrd1, an RNA-binding protein with RNA-recognition motifs, as a multicopy suppressor of cdc4 mutants. Notably, we demonstrated that Nrd1 binds and stabilizes Cdc4 mRNA, thereby suppressing the cytokinesis defects of the cdc4 mutants. Importantly, Pmk1 mitogen-activated protein kinase (MAPK) directly phosphorylates Nrd1, thereby negatively regulating the binding activity of Nrd1 to Cdc4 mRNA. Consistently, the inactivation of Pmk1 MAPK signaling, as well as Nrd1 overexpression, stabilized the Cdc4 mRNA level, thereby suppressing the cytokinesis defects associated with the cdc4 mutants. In addition, we demonstrated the cell cycle–dependent regulation of Pmk1/Nrd1 signaling. Together, our results indicate that Nrd1 plays a role in the regulation of Cdc4 mRNA stability; moreover, our study is the first to demonstrate the posttranscriptional regulation of myosin expression by MAPK signaling.

scholarly journals p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR

2009 ◽  
Vol 18 (21) ◽  
pp. 4035-4045 ◽  
Author(s):  
Faraz Farooq ◽  
Sylvia Balabanian ◽  
Xuejun Liu ◽  
Martin Holcik ◽  
Alex MacKenzie
Keyword(s):  
Protein Kinase ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein

scholarly journals G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A

2011 ◽  
Vol 6 ◽  
pp. 10 ◽  
Author(s):  
Anne Kristin Aksaas ◽  
Anja C V Larsen ◽  
Marie Rogne ◽  
Ken Rosendal ◽  
Anne-Katrine Kvissel ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Nuclear Rna ◽  
Kinase A
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