scholarly journals Oncolytic herpes simplex virus kills stem-like tumor-initiating colon cancer cells

2016 ◽  
Vol 3 ◽  
pp. 16013 ◽  
Author(s):  
Susanne G Warner ◽  
Dana Haddad ◽  
Joyce Au ◽  
Joshua S Carson ◽  
Michael P O’Leary ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Oncolytic Herpes Simplex Virus ◽  
Simplex Virus

scholarly journals Oncolytic Herpes Simplex Virus-Based Therapies for Cancer

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1541
Author(s):  
Norah Aldrak ◽  
Sarah Alsaab ◽  
Aliyah Algethami ◽  
Deepak Bhere ◽  
Hiroaki Wakimoto ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cancer Cells ◽  
Therapeutic Option ◽  
Genetically Engineered ◽  
Antitumor Effects ◽  
Oncolytic Herpes Simplex Virus ◽  
Simplex Virus ◽  
Direct Killing ◽  
Target Cancer

With the increased worldwide burden of cancer, including aggressive and resistant cancers, oncolytic virotherapy has emerged as a viable therapeutic option. Oncolytic herpes simplex virus (oHSV) can be genetically engineered to target cancer cells while sparing normal cells. This leads to the direct killing of cancer cells and the activation of the host immunity to recognize and attack the tumor. Different variants of oHSV have been developed to optimize its antitumor effects. In this review, we discuss the development of oHSV, its antitumor mechanism of action and the clinical trials that have employed oHSV variants to treat different types of tumor.

scholarly journals Infection with Oncolytic Herpes Simplex Virus-1 Induces Apoptosis in Neighboring Human Cancer Cells

2004 ◽  
Vol 10 (9) ◽  
pp. 3225-3232 ◽  
Author(s):  
Stephen F. Stanziale ◽  
Henrik Petrowsky ◽  
Prasad S. Adusumilli ◽  
Leah Ben-Porat ◽  
Mithat Gonen ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cancer Cells ◽  
Human Cancer ◽  
Herpes Simplex Virus 1 ◽  
Human Cancer Cells ◽  
Oncolytic Herpes Simplex Virus ◽  
Simplex Virus

scholarly journals Treatment of colon cancer with oncolytic herpes simplex virus in preclinical models

Gene Therapy ◽  
2016 ◽  
Vol 23 (5) ◽  
pp. 450-459 ◽  
Author(s):  
H Yang ◽  
T Peng ◽  
J Li ◽  
Y Wang ◽  
W Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Preclinical Models ◽  
Oncolytic Herpes Simplex Virus ◽  
Simplex Virus
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