scholarly journals Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus

2015 ◽  
Vol 23 (7) ◽  
pp. 1182-1188 ◽  
Author(s):  
Shuya Yano ◽  
Shinji Miwa ◽  
Hiroyuki Kishimoto ◽  
Makoto Toneri ◽  
Yukihiko Hiroshima ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery

scholarly journals Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster

2020 ◽  
Vol 149 (2) ◽  
pp. 243-252
Author(s):  
Clare W. Teng ◽  
Ahmad Amirshaghaghi ◽  
Steve S. Cho ◽  
Shuting S. Cai ◽  
Emma De Ravin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Glioblastoma Multiforme ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery

Optical imaging probes and their potential contribution to radiotracer development

2016 ◽  
Vol 55 (02) ◽  
pp. 51-62 ◽  
Author(s):  
S. Hermann ◽  
M. Schäfers ◽  
C. Höltke ◽  
A. Faust
Keyword(s):  
Optical Imaging ◽  
Fluorescent Dyes ◽  
Great Influence ◽  
Potential Contribution ◽  
Preclinical Evaluation ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Imaging Probes ◽  
Unspecific Binding

SummaryOptical imaging has long been considered a method for histological or microscopic investigations. Over the last 15 years, however, this method was applied for preclinical molecular imaging and, just recently, was also able to show its principal potential for clinical applications (e.g. fluorescence-guided surgery). Reviewing the development and preclinical evaluation of new fluorescent dyes and target-specific dye conjugates, these often show characteristic patterns of their routes of excretion and biodistribution, which could also be interesting for the development and optimization of radiopharmaceuticals. Especially ionic charges show a great influence on biodistribution and netcharge and charge-distribution on a conjugate often determines unspecific binding or background signals in liver, kidney or intestine, and other organs.Learning from fluorescent probe behaviour in vivo and translating this knowledge to radio-pharmaceuticals might be useful to further optimize emerging and existing radiopharmaceuticals with respect to their biodistribution and thereby availability for binding to their targets.

Sign in / Sign up

Export Citation Format

Share Document