scholarly journals Genetic Immunization With In Vivo Dendritic Cell-targeting Liposomal DNA Vaccine Carrier Induces Long-lasting Antitumor Immune Response

2016 ◽  
Vol 24 (2) ◽  
pp. 385-397 ◽  
Author(s):  
Arup Garu ◽  
Gopikrishna Moku ◽  
Suresh Kumar Gulla ◽  
Arabinda Chaudhuri
Keyword(s):  
Immune Response ◽  
Dendritic Cell ◽  
Dna Vaccine ◽  
Antitumor Immune Response ◽  
Cell Targeting ◽  
Genetic Immunization ◽  
Vaccine Carrier

Cationic Amphiphile with Shikimic Acid Headgroup Shows More Systemic Promise Than Its Mannosyl Analogue as DNA Vaccine Carrier in Dendritic Cell Based Genetic Immunization

2010 ◽  
Vol 53 (3) ◽  
pp. 1387-1391 ◽  
Author(s):  
Ramishetti Srinivas ◽  
Priya P. Karmali ◽  
Dipankar Pramanik ◽  
Arup Garu ◽  
Yenugonda Venkata Mahidhar ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Dna Vaccine ◽  
Shikimic Acid ◽  
Genetic Immunization ◽  
Vaccine Carrier ◽  
Cationic Amphiphile

Corrections to Cationic Amphiphile with Shikimic Acid Headgroup Shows More Systemic Promise Than Its Mannosyl Analogue as DNA Vaccine Carrier in Dendritic Cell Based Genetic Immunization

2010 ◽  
Vol 53 (7) ◽  
pp. 3003-3003 ◽  
Author(s):  
Ramishetti Srinivas ◽  
Priya P. Karmali ◽  
Dipankar Pramanik ◽  
Arup Garu ◽  
Yenugonda Venkata Mahidhar ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Dna Vaccine ◽  
Shikimic Acid ◽  
Genetic Immunization ◽  
Vaccine Carrier ◽  
Cationic Amphiphile

scholarly journals Dendritic Cell Targeting Effectively Boosts T Cell Responses Elicited by an HIV Multiepitope DNA Vaccine

2017 ◽  
Vol 8 ◽  
Author(s):  
Juliana de Souza Apostólico ◽  
Victória Alves Santos Lunardelli ◽  
Marcio Massao Yamamoto ◽  
Higo Fernando Santos Souza ◽  
Edecio Cunha-Neto ◽  
...  
Keyword(s):  
T Cell ◽  
Dendritic Cell ◽  
Dna Vaccine ◽  
T Cell Responses ◽  
Cell Targeting ◽  
Cell Responses

scholarly journals Angiostatic activity of the antitumor cytokine interleukin-21

Blood ◽  
2008 ◽  
Vol 112 (13) ◽  
pp. 4940-4947 ◽  
Author(s):  
Karolien Castermans ◽  
Sebastien P. Tabruyn ◽  
Rong Zeng ◽  
Judy R. van Beijnum ◽  
Cheryl Eppolito ◽  
...  
Keyword(s):  
Immune Response ◽  
Tumor Angiogenesis ◽  
Chorioallantoic Membrane ◽  
Antitumor Immune Response ◽  
In Vivo Studies ◽  
Type I ◽  
Stat3 Phosphorylation ◽  
Interleukin 21

Abstract Interleukin-21 (IL-21) is a recently described immunoregulatory cytokine. It has been identified as a very potent immunotherapeutic agent in several cancer types in animal models, and clinical studies are ongoing. IL-21 belongs to the type I cytokine family of which other members, ie, IL-2, IL-15, and IL-4, have been shown to exert activities on vascular endothelial cells (ECs). We hypothesized that IL-21, in addition to inducing the antitumor immune response, also inhibits tumor angiogenesis. In vitro experiments showed a decrease of proliferation and sprouting of activated ECs after IL-21 treatment. We found that the IL-21 receptor is expressed on vascular ECs. Furthermore, in vivo studies in the chorioallantoic membrane of the chick embryo and in mouse tumors demonstrated that IL-21 treatment disturbs vessel architecture and negatively affects vessel outgrowth. Our results also confirm the earlier suggested angiostatic potential of IL-2 in vitro and in vivo. The angiostatic effect of IL-21 is confirmed by the decrease in expression of angiogenesis-related genes. Interestingly, IL-21 treatment of ECs leads to a decrease of Stat3 phosphorylation. Our research shows that IL-21 is a very powerful antitumor compound that combines the induction of an effective antitumor immune response with inhibition of tumor angiogenesis.

scholarly journals Effects of Regulatory T Cell Depletion on NK Cell Responses against Listeria monocytogenes in Feline Immunodeficiency Virus Infected Cats

Viruses ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 984
Author(s):  
Simões ◽  
LaVoy ◽  
Dean
Keyword(s):  
Immune Response ◽  
Listeria Monocytogenes ◽  
Dendritic Cell ◽  
Innate Immune Response ◽  
Feline Immunodeficiency Virus ◽  
Innate Immune ◽  
Treg Depletion ◽  
Cell Responses ◽  
Immunodeficiency Virus

Regulatory T cells (Treg) are key players in the maintenance of peripheral tolerance, preventing autoimmune diseases and restraining chronic inflammatory diseases. Evidence suggests Treg cells and NK cells have important roles in feline immunodeficiency virus (FIV) pathogenesis; however, in vivo studies investigating the interplay between these two cell populations are lacking. We previously described innate immune defects in FIV-infected cats characterized by cytokine deficits and impaired natural killer cell (NK) and NK T cell (NKT) functions. In this study, we investigated whether in vivo Treg depletion by treatment with an anti-feline CD25 monoclonal antibody would improve the innate immune response against subcutaneous challenge with Listeria monocytogenes (Lm). Treg depletion resulted in an increased overall number of cells in Lm-draining lymph nodes and increased proliferation of NK and NKT cells in FIV-infected cats. Treg depletion did not normalize expression of perforin or granzyme A by NK and NKT cells, nor did Treg depletion result in improved clearance of Lm. Thus, despite the quantitative improvements in the NK and NKT cell responses to Lm, there was no functional improvement in the early control of Lm. CD1a+ dendritic cell percentages in the lymph nodes of FIV-infected cats were lower than in specific-pathogen-free control cats and failed to upregulate CD80 even when Treg were depleted. Taken together, Treg depletion failed to improve the innate immune response of FIV-infected cats against Lm and this may be due to dendritic cell dysfunction.

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