scholarly journals Intranasal Delivery of Mesenchymal Stem Cells Significantly Extends Survival of Irradiated Mice with Experimental Brain Tumors

2014 ◽  
Vol 22 (1) ◽  
pp. 140-148 ◽  
Author(s):  
Irina V Balyasnikova ◽  
Melanie S Prasol ◽  
Sherise D Ferguson ◽  
Yu Han ◽  
Atique U Ahmed ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Tumors ◽  
Intranasal Delivery ◽  
Experimental Brain Tumors

scholarly journals Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hadas Tsivion-Visbord ◽  
Nisim Perets ◽  
Tamar Sofer ◽  
Lior Bikovski ◽  
Yona Goldshmit ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Extracellular Vesicles ◽  
Gabaergic Interneurons ◽  
Intranasal Delivery ◽  
The Core ◽  
Novel Treatment ◽  
Number Of Patients ◽  
Immunohistochemical Studies ◽  
The Brain

Abstract Schizophrenia is a debilitating psychiatric disorder with a significant number of patients not adequately responding to treatment. Phencyclidine (PCP) is used as a validated model for schizophrenia, shown to reliably induce positive, negative and cognitive-like behaviors in rodents. It was previously shown in our lab that behavioral phenotypes of PCP-treated mice can be alleviated after intracranial transplantation of mesenchymal stem cells (MSC). Here, we assessed the feasibility of intranasal delivery of MSCs-derived-extracellular vesicles (EVs) to alleviate schizophrenia-like behaviors in a PCP model of schizophrenia. As MSCs-derived EVs were already shown to concentrate at the site of lesion in the brain, we determined that in PCP induced injury the EVs migrate to the prefrontal cortex (PFC) of treated mice, a most involved area of the brain in schizophrenia. We show that intranasal delivery of MSC-EVs improve social interaction and disruption in prepulse inhibition (PPI) seen in PCP-treated mice. In addition, immunohistochemical studies demonstrate that the EVs preserve the number of parvalbumin-positive GABAergic interneurons in the PFC of treated mice. Finally, MSCs-EVs reduced glutamate levels in the CSF of PCP-treated mice, which might explain the reduction of toxicity. In conclusion, we show that MSCs-EVs improve the core schizophrenia-like behavior and biochemical markers of schizophrenia and might be used as a novel treatment for this incurable disorder.

scholarly journals DIPG-19. MESENCHYMAL STEM CELLS TARGET DIFFUSE INTRINSIC PONTINE GLIOMA IN MICE AFTER INTRANASAL DELIVERY

2017 ◽  
Vol 19 (suppl_4) ◽  
pp. iv8-iv8
Author(s):  
Michael Chastkofsky ◽  
Daniele Procissi ◽  
Cynthia Yang ◽  
Stewart Goldman ◽  
Maciej Lesniak ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Diffuse Intrinsic Pontine Glioma ◽  
Intranasal Delivery ◽  
Pontine Glioma

scholarly journals From Blood to the Brain: Can Systemically Transplanted Mesenchymal Stem Cells Cross the Blood-Brain Barrier?

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Linan Liu ◽  
Mark A. Eckert ◽  
Hamidreza Riazifar ◽  
Dong-Ku Kang ◽  
Dritan Agalliu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Tumors ◽  
Blood Brain Barrier ◽  
Inflammatory Diseases ◽  
Neurological Diseases ◽  
Brain Barrier ◽  
Therapeutic Effects ◽  
Blood Brain ◽  
The Brain

Systemically infused mesenchymal stem cells (MSCs) are emerging therapeutics for treating stroke, acute injuries, and inflammatory diseases of the central nervous system (CNS), as well as brain tumors due to their regenerative capacity and ability to secrete trophic, immune modulatory, or other engineered therapeutic factors. It is hypothesized that transplanted MSCs home to and engraft at ischemic and injured sites in the brain in order to exert their therapeutic effects. However, whether MSCs possess the ability to migrate across the blood-brain barrier (BBB) that separates the blood from the brain remains unresolved. This review analyzes recent advances in this area in an attempt to elucidate whether systemically infused MSCs are able to actively transmigrate across the CNS endothelium, particularly under conditions of injury or stroke. Understanding the fate of transplanted MSCs and their CNS trafficking mechanisms will facilitate the development of more effective stem-cell-based therapeutics and drug delivery systems to treat neurological diseases and brain tumors.

Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors

Biomaterials ◽  
2010 ◽  
Vol 31 (32) ◽  
pp. 8393-8401 ◽  
Author(s):  
Mathilde Roger ◽  
Anne Clavreul ◽  
Marie-Claire Venier-Julienne ◽  
Catherine Passirani ◽  
Laurence Sindji ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Tumors

scholarly journals p27 modulates tropism of mesenchymal stem cells toward brain tumors

2010 ◽  
Vol 1 (4) ◽  
pp. 695-699 ◽  
Author(s):  
YUN GAO ◽  
CHUNYU GU ◽  
SHAOYI LI ◽  
TSUTOMU TOKUYAMA ◽  
NAOKI YOKOTA ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Tumors

Intranasal Delivery of Umbilical Cord-Derived Mesenchymal Stem Cells Preserves Myelination in Perinatal Brain Damage

2016 ◽  
Vol 25 (16) ◽  
pp. 1234-1242 ◽  
Author(s):  
Byron Oppliger ◽  
Marianne Joerger-Messerli ◽  
Martin Mueller ◽  
Ursula Reinhart ◽  
Philipp Schneider ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Brain Damage ◽  
Umbilical Cord ◽  
Intranasal Delivery ◽  
Perinatal Brain Damage
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