scholarly journals Do Cell-Penetrating Peptides Actually “Penetrate” Cellular Membranes?

2012 ◽  
Vol 20 (4) ◽  
pp. 695-697 ◽  
Author(s):  
Caroline Palm-Apergi ◽  
Peter Lönn ◽  
Steven F Dowdy
Keyword(s):  
Cell Penetrating Peptides ◽  
Cellular Membranes ◽  
Cell Penetrating

scholarly journals Cell-penetrating peptides containing 2,5-diketopiperazine (DKP) scaffolds as shuttles for anti-cancer drugs: conformational studies and biological activity

2020 ◽  
Vol 56 (42) ◽  
pp. 5685-5688
Author(s):  
Lucia Feni ◽  
Linda Jütten ◽  
Sara Parente ◽  
Umberto Piarulli ◽  
Ines Neundorf ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cell Penetrating Peptides ◽  
Cancer Drugs ◽  
Cellular Membranes ◽  
Conformational Studies ◽  
Cellular Translocation ◽  
Anti Cancer ◽  
Cell Penetrating

Cargo-peptides approaching cellular membranes: influence of cyclization and stereochemistry on cellular translocation activity of a novel group of cell-penetrating peptides containing bifunctional diketopiperazine.

Oncolytic Coxsackievirus and the Mechanisms of its Effects on Cancer: A Narrative Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Ali Ahmadi ◽  
Hadi Esmaeili Gouvarchin Ghaleh ◽  
Ruhollah Dorostkar ◽  
Mahdieh Farzanehpour ◽  
Masoumeh Bolandian
Keyword(s):  
Genetic Disease ◽  
Control Cell ◽  
Gene Mutations ◽  
Therapeutic Agents ◽  
Cell Penetrating Peptides ◽  
Triggered Release ◽  
New Techniques ◽  
Viral Therapy ◽  
Cell Penetrating ◽  
Cancer Cell Targeting

Abstract:: Cancer is a genetic disease triggered by gene mutations, which control cell growth and their functionality inherited from previous generations. The targeted therapy of some tumors was not especially successful. A host of new techniques can be used to treat aptamer-mediated targeting, cancer immunotherapy, cancer stem cell (CSC) therapy, cell-penetrating peptides (CPPs), hormone therapy, intracellular cancer cell targeting, nanoparticles, and viral therapy. These include chemical-analog conjugation, gene delivery, ligand-receptor-based targeting, prodrug therapies, and triggered release strategies. Virotherapy is a biotechnological technique for turning viruses into therapeutic agents by the reprogramming of viruses to cure diseases. In several tumors, including melanoma, multiple myeloma, bladder cancer, and breast cancer, the oncolytic capacity of oncolytic Coxsackievirus has been studied. The present study aims to assess oncolytic Coxsackievirus and its mechanisms of effect on cancer cells.

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