scholarly journals Human Artificial Chromosomes for Gene Delivery and the Development of Animal Models

2011 ◽  
Vol 19 (9) ◽  
pp. 1591-1601 ◽  
Author(s):  
Yasuhiro Kazuki ◽  
Mitsuo Oshimura
Keyword(s):  
Animal Models ◽  
Gene Delivery ◽  
Artificial Chromosomes

Gene delivery to large animal models using AAV vectors

2015 ◽  
Vol 25 ◽  
pp. S290
Author(s):  
J. Chamberlain ◽  
J. Seto ◽  
J. Ramos ◽  
S. Hauschka ◽  
G. Odom
Keyword(s):  
Animal Models ◽  
Gene Delivery ◽  
Large Animal ◽  
Large Animal Models

scholarly journals Animal Models for Hydrodynamic Gene Delivery

10.5772/35118 ◽  
2012 ◽  
Author(s):  
Michalis Katsimpoulas ◽  
Dimitris Zacharoulis ◽  
Nagy Habib ◽  
Alkiviadis Kostakis
Keyword(s):  
Animal Models ◽  
Gene Delivery

Direct Gene Therapy for Bone Regeneration: Gene Delivery, Animal Models, and Outcome Measures

2009 ◽  
pp. 110306231138043 ◽  
Author(s):  
Gadi Pelled ◽  
Ayelet Ben-Arav ◽  
Colleen Hock ◽  
David G. Reynolds ◽  
Cemal Yazici ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Animal Models ◽  
Gene Delivery ◽  
Bone Regeneration ◽  
Outcome Measures ◽  
Direct Gene

Centromere identity and function put to use: construction and transfer of mammalian artificial chromosomes to animal models

2020 ◽  
Vol 64 (2) ◽  
pp. 185-192
Author(s):  
Ye Yang ◽  
Michael A. Lampson ◽  
Ben E. Black
Keyword(s):  
Gene Expression ◽  
Cell Culture ◽  
Animal Model ◽  
Synthetic Biology ◽  
Animal Models ◽  
Model Systems ◽  
Expression Vectors ◽  
Artificial Chromosomes ◽  
Conventional Expression ◽  
And Function

Abstract Mammalian artificial chromosomes (MACs) are widely used as gene expression vectors and have various advantages over conventional expression vectors. We review and discuss breakthroughs in MAC construction, initiation of functional centromeres allowing their faithful inheritance, and transfer from cell culture to animal model systems. These advances have contributed to advancements in synthetic biology, biomedical research, and applications in industry and in the clinic.

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