scholarly journals Increased Expression of Catalase and Superoxide Dismutase 2 Reduces Cone Cell Death in Retinitis Pigmentosa

2009 ◽  
Vol 17 (5) ◽  
pp. 778-786 ◽  
Author(s):  
Shinichi Usui ◽  
Keiichi Komeima ◽  
Sun Young Lee ◽  
Young-Joon Jo ◽  
Shinji Ueno ◽  
...  
Keyword(s):  
Cell Death ◽  
Superoxide Dismutase ◽  
Retinitis Pigmentosa ◽  
Cone Cell ◽  
Superoxide Dismutase 2

Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa

2005 ◽  
Vol 203 (3) ◽  
pp. 457-464 ◽  
Author(s):  
JiKui Shen ◽  
Xiaoru Yang ◽  
Aling Dong ◽  
Robert M. Petters ◽  
You-Wei Peng ◽  
...  
Keyword(s):  
Cell Death ◽  
Oxidative Damage ◽  
Retinitis Pigmentosa ◽  
Cone Cell

scholarly journals Antioxidants reduce cone cell death in a model of retinitis pigmentosa

2006 ◽  
Vol 103 (30) ◽  
pp. 11300-11305 ◽  
Author(s):  
K. Komeima ◽  
B. S. Rogers ◽  
L. Lu ◽  
P. A. Campochiaro
Keyword(s):  
Cell Death ◽  
Retinitis Pigmentosa ◽  
Cone Cell

scholarly journals Gypenosides Alleviate Cone Cell Death in a Zebrafish Model of Retinitis Pigmentosa

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1050
Author(s):  
Xing Li ◽  
Reem Hasaballah Alhasani ◽  
Yanqun Cao ◽  
Xinzhi Zhou ◽  
Zhiming He ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinitis Pigmentosa ◽  
Network Pharmacology ◽  
Genetic Abnormality ◽  
Hub Genes ◽  
Zebrafish Model ◽  
Cone Cell ◽  
Antioxidant Genes ◽  
Rod Cells ◽  
Cone Cells

Retinitis pigmentosa (RP) is a group of visual disorders caused by mutations in over 70 genes. RP is characterized by initial degeneration of rod cells and late cone cell death, regardless of genetic abnormality. Rod cells are the main consumers of oxygen in the retina, and after the death of rod cells, the cone cells have to endure high levels of oxygen, which in turn leads to oxidative damage and cone degeneration. Gypenosides (Gyp) are major dammarane-type saponins of Gynostemma pentaphyllum that are known to reduce oxidative stress and inflammation. In this project we assessed the protective effect of Gyp against cone cell death in the rpgrip1 mutant zebrafish, which recapitulate the classical pathological features found in RP patients. Rpgrip1 mutant zebrafish were treated with Gyp (50 µg/g body weight) from two-months post fertilization (mpf) until 6 mpf. Gyp treatment resulted in a significant decrease in cone cell death compared to that of untreated mutant zebrafish. A markedly low level of reactive oxygen species and increased expression of antioxidant genes were detected in Gyp-incubated mutant zebrafish eyes compared to that of untreated mutant zebrafish. Similarly, the activities of catalase and superoxide dismutase and the level of glutathione were significantly increased in Gyp-treated mutant zebrafish eyes compared to that of untreated mutant zebrafish. Gyp treatment also decreased endoplasmic reticulum stress in rpgrip1 mutant eyes. Expression of proinflammatory cytokines was also significantly decreased in Gyp-treated mutant zebrafish eyes compared to that of untreated mutant zebrafish. Network pharmacology analysis demonstrated that the promotion of cone cell survival by Gyp is possibly mediated by multiple hub genes and associated signalling pathways. These data suggest treatment with Gyp will benefit RP patients.

The mechanism of cone cell death in Retinitis Pigmentosa

2018 ◽  
Vol 62 ◽  
pp. 24-37 ◽  
Author(s):  
Peter A. Campochiaro ◽  
Tahreem A. Mir
Keyword(s):  
Cell Death ◽  
Retinitis Pigmentosa ◽  
Cone Cell

scholarly journals Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa

2008 ◽  
Vol 45 (6) ◽  
pp. 905-912 ◽  
Author(s):  
Keiichi Komeima ◽  
Shinichi Usui ◽  
Jikui Shen ◽  
Brian S. Rogers ◽  
Peter A. Campochiaro
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Nitric Oxide Synthase ◽  
Retinitis Pigmentosa ◽  
Neuronal Nitric Oxide Synthase ◽  
Cone Cell ◽  
Oxide Synthase

scholarly journals NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa

2009 ◽  
Vol 110 (3) ◽  
pp. 1028-1037 ◽  
Author(s):  
Shinichi Usui ◽  
Brian C. Oveson ◽  
Sun Young Lee ◽  
Young-Joon Jo ◽  
Tsunehiko Yoshida ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinitis Pigmentosa ◽  
Nadph Oxidase ◽  
Cone Cell

scholarly journals 222 SUPEROXIDE DISMUTASE 2 DOWNREGULATION AND MITOCHONDRIA RESPIRATION IN OSTEOARTHRITIS

2010 ◽  
Vol 18 ◽  
pp. S103-S104
Author(s):  
C. Gabrielides ◽  
J.L. Scott ◽  
R.W. Taylor ◽  
D.A. Young
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Dismutase 2

Are Superoxide Dismutase 2 and Nitric Oxide Synthase Polymorphisms Associated with Idiopathic Infertility?

2014 ◽  
Vol 21 (4) ◽  
pp. 565-569 ◽  
Author(s):  
Celine Faure ◽  
Pauline Leveille ◽  
Charlotte Dupont ◽  
Chantal Julia ◽  
Pascale Chavatte-Palmer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Nitric Oxide Synthase ◽  
Idiopathic Infertility ◽  
Oxide Synthase ◽  
Superoxide Dismutase 2

Effects of Superoxide Dismutase Inhibitors and Glucose on Cell Death and Generation of Reactive Oxygen Species in Pea Leaves

2021 ◽  
Vol 86 (7) ◽  
pp. 878-886
Author(s):  
Vitaly D. Samuilov ◽  
Dmitry B. Kiselevsky ◽  
Elena V. Dzyubinskaya ◽  
Olga Yu. Frolova
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Superoxide Dismutase ◽  
Reactive Oxygen ◽  
Oxygen Species
Sign in / Sign up

Export Citation Format

Share Document