scholarly journals Transplantation of Human Embryonic Stem Cell–Derived Alveolar Epithelial Type II Cells Abrogates Acute Lung Injury in Mice

2010 ◽  
Vol 18 (3) ◽  
pp. 625-634 ◽  
Author(s):  
Dachun Wang ◽  
John E Morales ◽  
Daniel G Calame ◽  
Joseph L Alcorn ◽  
Rick A Wetsel
Keyword(s):  
Stem Cell ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Type Ii Cells ◽  
Type Ii ◽  
Alveolar Epithelial

Human embryonic stem cell derived alveolar epithelial type II cells express C3 and C5

2007 ◽  
Vol 44 (1-3) ◽  
pp. 255
Author(s):  
Dachun Wang ◽  
David L. Haviland ◽  
Eva Zsigmond ◽  
Rick A. Wetsel
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Type Ii Cells ◽  
Type Ii ◽  
Alveolar Epithelial

Prophylactic and therapeutic approaches to acute lung injury, targeting alveolar epithelial type II cells

2007 ◽  
Vol 21 (1) ◽  
pp. 120-121
Author(s):  
Katsuya Mikawa ◽  
Kahoru Nishina ◽  
Takuyo Misumi ◽  
Toshihiro Ando ◽  
Hidefumi Obara
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Type Ii Cells ◽  
Type Ii ◽  
Therapeutic Approaches ◽  
Alveolar Epithelial

scholarly journals Acute Lung Injury Edema Fluid Decreases Net Fluid Transport across Human Alveolar Epithelial Type II Cells

2007 ◽  
Vol 282 (33) ◽  
pp. 24109-24119 ◽  
Author(s):  
Jae W. Lee ◽  
Xiaohui Fang ◽  
Gregory Dolganov ◽  
Richard D. Fremont ◽  
Julie A. Bastarache ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Fluid Transport ◽  
Type Ii Cells ◽  
Type Ii ◽  
Alveolar Epithelial ◽  
Edema Fluid

scholarly journals A Combination of Human Embryonic Stem Cell-Derived Pancreatic Endoderm Transplant with LDHA-Repressing miRNA Can Attenuate High-Fat Diet Induced Type II Diabetes in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Yunya Chen ◽  
Xiujie Wang ◽  
Xinyu Shao
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
High Fat Diet ◽  
Type Ii Diabetes ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Type Ii Diabetes Mellitus ◽  
Type Ii ◽  
High Fat ◽  
Diabetes In Mice

Type II diabetes mellitus (T2D) is a chronic metabolic disorder that results from defects in both insulin secretion and insulin action. The deficit and dysfunction of insulin secretingβ-cell are signature symptom for T2D. Additionally, in pancreaticβ-cell, a small group of genes which are abundantly expressed in most other tissues are highly selectively repressed. Lactate dehydrogenase A (LDHA) is one of such genes. Upregulation of LDHA is found in both human T2D and rodent T2D models. In this study, we identified a LDHA-suppressing microRNA (hsa-miR-590-3p) and used it together with human embryonic stem cell (hESC) derived pancreatic endoderm (PE) transplantation into a high-fat diet induced T2D mouse model. The procedure significantly improved glucose metabolism and other symptoms of T2D. Our findings support the potential T2D treatment using the combination of microRNA and hESC-differentiated PE cells.

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

2020 ◽  
Author(s):  
Wamaitha SE ◽  
Grybel KJ ◽  
Alanis-Lobato G ◽  
Gerri C ◽  
Ogushi S ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Self Renewal
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