scholarly journals Long-term Transgene Expression in the Central Nervous System Using DNA Nanoparticles

2009 ◽  
Vol 17 (4) ◽  
pp. 641-650 ◽  
Author(s):  
David M Yurek ◽  
Anita M Fletcher ◽  
George M Smith ◽  
Kim B Seroogy ◽  
Assem G Ziady ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transgene Expression ◽  
Dna Nanoparticles ◽  
The Central Nervous System

scholarly journals Engineered HSV vector achieves safe long-term transgene expression in the central nervous system

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Gianluca Verlengia ◽  
Yoshitaka Miyagawa ◽  
Selene Ingusci ◽  
Justus B. Cohen ◽  
Michele Simonato ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Transgene Expression ◽  
The Central Nervous System

scholarly journals Self-buffering capacity of a human sulfatase for central nervous system delivery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yi Wen ◽  
Nazila Salamat-Miller ◽  
Keethkumar Jain ◽  
Katherine Taylor
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Buffering Capacity ◽  
The Self ◽  
High Concentration ◽  
Formulation Design ◽  
The Central Nervous System ◽  
Therapeutic Enzymes ◽  
Intrathecal Space

AbstractDirect delivery of therapeutic enzymes to the Central Nervous System requires stringent formulation design. Not only should the formulation design consider the delicate balance of existing ions, proteins, and osmolality in the cerebrospinal fluid, it must also provide long term efficacy and stability for the enzyme. One fundamental approach to this predicament is designing formulations with no buffering species. In this study, we report a high concentration, saline-based formulation for a human sulfatase for its delivery into the intrathecal space. A high concentration formulation (≤ 40 mg/mL) was developed through a series of systematic studies that demonstrated the feasibility of a self-buffered formulation for this molecule. The self-buffering capacity phenomenon was found to be a product of both the protein itself and potentially the residual phosphates associated with the protein. To date, the self-buffered formulation for this molecule has been stable for up to 4 years when stored at 5 ± 3 °C, with no changes either in the pH values or other quality attributes of the molecule. The high concentration self-buffered protein formulation was also observed to be stable when exposed to multiple freeze–thaw cycles and was robust during in-use and agitation studies.

Mycophenolate mofetil as induction and long-term maintaining treatment in childhood: Primary angiitis of the central nervous system

2017 ◽  
Vol 84 (3) ◽  
pp. 353-356 ◽  
Author(s):  
Anna Rosati ◽  
Alessandra Cosi ◽  
Massimo Basile ◽  
Alice Brambilla ◽  
Renzo Guerrini ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mycophenolate Mofetil ◽  
Primary Angiitis ◽  
The Central Nervous System

Long-term impact of neonatal inflammation on demyelination and remyelination in the central nervous system

Glia ◽  
2014 ◽  
Vol 62 (10) ◽  
pp. 1659-1670 ◽  
Author(s):  
Karelle Bénardais ◽  
Viktoria Gudi ◽  
Lijie Gai ◽  
Jasmin Neßler ◽  
Vikramjeet Singh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
The Central Nervous System ◽  
Long Term Impact

Hormonal-sympathetic interactions in long-term regulation of arterial pressure: an hypothesis

1995 ◽  
Vol 268 (6) ◽  
pp. R1343-R1358 ◽  
Author(s):  
V. L. Brooks ◽  
J. W. Osborn
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Arterial Pressure ◽  
Plasma Concentrations ◽  
Circumventricular Organs ◽  
Feedback Signal ◽  
Salt Loading ◽  
Alternate Model ◽  
The Central Nervous System

The importance of the sympathetic nervous system in short-term regulation of arterial pressure is well accepted. However, the question of whether neural systems participate in long-term control of pressure has been debated for decades and remains unresolved. The principal argument against such a control system is that arterial baroreceptors adapt to sustained changes in arterial pressure. In addition, denervation of baroreceptors has minimal to no effect on basal levels of arterial pressure chronically. This argument assumes, however, that baroreceptors provide the primary chronic feedback signal to the central nervous system. An alternate model is proposed in which circulating hormones, primarily arginine vasopressin and angiotensin II, provide a long-term afferent signal to the central nervous system via binding to specific receptors in central sites lacking a blood-brain barrier (circumventricular organs). Studies suggest that the release of the hormones and the sympathetic response to alterations in their plasma concentrations are nonadaptive but may be gated by baroreceptor input. Evidence that this "hormonal-sympathetic reflex" model may explain the long-term alterations in sympathetic activity in response to chronic salt depletion and salt loading as well as congestive heart failure is presented. Finally, the role of an impaired hormonal sympathetic reflex in hypertension, specifically salt-dependent hypertension, is discussed.

scholarly journals Cerebellar Neurocysticercosis as Long-Term Complication of Allogeneic Haematopoietic Stem Cell Transplantation from Haploidentical Donor

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Federico Meconi ◽  
Giulia Ciangola ◽  
Benedetta Mariotti ◽  
Raffaella Cerretti ◽  
Laura Cudillo ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Taenia Solium ◽  
Haematopoietic Stem Cell ◽  
The Central Nervous System

Neurocysticercosis, an infection of the central nervous system with the larval stage of the cestode Taenia solium, is uncommon in developed countries. We report a case of allogeneic haematopoietic stem cell transplantation from a haploidentical donor complicated, in the long term, by T. solium infection of the central nervous system and successfully treated with empiric antiparasitic therapy with albendazole plus dexamethasone. Revised diagnostic criteria proposed by Del Brutto et al. were used for the definitive diagnosis of cerebellar neurocysticercosis.

Relapse rates and long-term outcome in primary angiitis of the central nervous system

2019 ◽  
Vol 266 (6) ◽  
pp. 1481-1489 ◽  
Author(s):  
Simon Schuster ◽  
Ann-Kathrin Ozga ◽  
Jan-Patrick Stellmann ◽  
Milani Deb-Chatterji ◽  
Vivien Häußler ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Primary Angiitis ◽  
The Central Nervous System ◽  
Relapse Rates
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