scholarly journals Targeting Hypoxia-inducible Factor-1α With Tf–PEI–shRNA Complex via Transferrin Receptor–mediated Endocytosis Inhibits Melanoma Growth

2009 ◽  
Vol 17 (2) ◽  
pp. 269-277 ◽  
Author(s):  
Yeqiang Liu ◽  
Juan Tao ◽  
Yan Li ◽  
Jing Yang ◽  
Yan Yu ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α ◽  
Receptor Mediated Endocytosis ◽  
Melanoma Growth

The critical role of mast cell-derived hypoxia-inducible factor-1α in human and mice melanoma growth

2012 ◽  
Vol 132 (11) ◽  
pp. 2492-2501 ◽  
Author(s):  
Hyun-Ja Jeong ◽  
Hyun-A Oh ◽  
Sun-Young Nam ◽  
Na-Ra Han ◽  
Young-Sick Kim ◽  
...  
Keyword(s):  
Mast Cell ◽  
Critical Role ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α ◽  
Melanoma Growth

scholarly journals MicroRNA-138 negatively regulates the hypoxia-inducible factor 1α to suppress melanoma growth and metastasis

2019 ◽  
Author(s):  
Haijiang Qiu ◽  
Fangchao Chen ◽  
Minjun Chen
Keyword(s):  
Hypoxia Inducible Factor ◽  
Significant Negative Correlation ◽  
Bioinformatic Analysis ◽  
Migration And Invasion ◽  
Rapid Progression ◽  
Hypoxia Inducible Factor 1Α ◽  
Melanoma Tissue ◽  
Melanoma Growth ◽  
A375 Cells

ABSTRACTMelanoma with rapid progression towards metastasis becomes the deadliest form of skin cancer. However, the mechanism of melanoma growth and metastasis is still unclear. Here, we found that miRNA-138 was low expression and hypoxia-inducible factor 1α (HIF1α) was high expression in the patient’s melanoma tissue, and they had a significant negative correlation (r = -0.937, P < 0.001). Patients with miRNA-138low/HIF1αhigh signature were predominant in late stage. Further, bioinformatic analysis demonstrated that miRNA-138 directly targeted HIF1α. We found that the introduction of miRNA-138 mimics to A375 cells could reduced HIF1α mRNA expression, and suppressed the cell proliferation, migration and invasion. Overexpression of miRNA-138 or inhibition of HIF1α significantly suppressed the growth and metastasis of melanoma in vivo. Our study demonstrates the role and clinical relevance of miRNA-138 and HIF1α in melanoma cell growth and metastasis, providing a novel therapeutic target for suppression of melanoma growth and metastasis.

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