scholarly journals The complexities of antibiotic action

2007 ◽  
Vol 3 (1) ◽  
pp. 142 ◽  
Author(s):  
Robert E W Hancock
Keyword(s):  
Antibiotic Action

5-Benzylidene-4-Oxazolidinones are Synergistic with Antibiotics for the Treatment of Staphylococcus Aureus Biofilms

2019 ◽  
Author(s):  
Bram Frohock ◽  
Jessica M. Gilbertie ◽  
Jennifer C. Daiker ◽  
Lauren V. Schnabel ◽  
Joshua Pierce
Keyword(s):  
Staphylococcus Aureus ◽  
Human Health ◽  
Matrix Model ◽  
Bacterial Load ◽  
Collagen Matrix ◽  
Resistance Mechanisms ◽  
Novel Therapeutics ◽  
Innovative Treatment ◽  
Antibiotic Action ◽  
Biofilm Infection

<div>The failure of frontline antibiotics in the clinic is one of the most serious threats to human health and requires a multitude of novel therapeutics and innovative treatment approaches to curtail the growing crisis. In addition to traditional resistance mechanisms resulting in the lack of efficacy of many antibiotics, most chronic and recurring infections are further made tolerant to antibiotic action by the presence of biofilms. Herein, we report an expanded set of 5-benzylidene-4-oxazolidinones that are able to inhibit the formation of Staphylococcus aureus biofilms, disperse preformed biofilms and in combination with common antibiotics are able to significantly reduce the bacterial load in a robust collagen-matrix model of biofilm infection.</div>

scholarly journals Antibiotic Action on Enzymes Involved in Peptidoglycan Synthesis

1975 ◽  
pp. 380-390
Author(s):  
Harold R. Perkins ◽  
Jean-Marie Ghuysen ◽  
Jean-Marie Frère ◽  
Manuel Nieto
Keyword(s):  
Peptidoglycan Synthesis ◽  
Antibiotic Action

scholarly journals The Reversal of Antibiotic Action

1948 ◽  
Vol 55 (2) ◽  
pp. 175-182 ◽  
Author(s):  
John Hays Bailey ◽  
Chester J. Cavallito
Keyword(s):  
Antibiotic Action

scholarly journals The Antibiofilm Activity of Dual-Function Tail Tubular Protein B from KP32 Phage

2018 ◽  
Author(s):  
Ewa Brzozowska ◽  
Anna Pyra ◽  
Krzysztof Pawlik ◽  
Sabina Górska ◽  
Andrzej Gamian
Keyword(s):  
Klebsiella Pneumoniae ◽  
Enterococcus Faecalis ◽  
Biofilm Formation ◽  
Hydrolytic Activity ◽  
Bacterial Biofilm ◽  
Dual Function ◽  
Antibiofilm Activity ◽  
Synergistic Activity ◽  
Antibiotic Action ◽  
Phage Protein

Background: Dual function tail tubular proteins (TTP) belonging to the lytic bacteriophages are the interesting group of biologically active enzymes. Surprisingly, apart from their structural function, they are also polysaccharide hydrolyzes destroying bacterial extracellular components. One of the representatives of this group is TTPB from Klebsiella pneumoniae phage &ndash; KP32. TTPB hydrolyzes exopolysaccharide (EPS) of Klebsiella pneumoniae and Enterococcus faecalis strain. This depolymerizing feature was associated with the activity to prevent bacterial biofilm formation. TTPB can inhibit biofilm formation by K. pneumoniae, Enterobacter cloacae, Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa strains. Moreover, synergistic activity with antibiotic action has been observed, most likely due to depolymerases&rsquo; facilitation of contact of antibiotic with bacterial cells. Methods: TTPB was overexpressed in E coli system, purified and tested towards the bacterial strains using agar overlay method. The hydrolytic activity of TTPB was performed using EPSs of K. pneumoniae PCM2713 and E. cloacae ATCC 13047 as the substrates. Next, we determined the reducing sugar (RS) levels in the TTPB/EPS mixtures, regarding the RS amount obtained after acidic hydrolysis. The antibiofilm activity of TTPB has been set down on bacterial biofilm using a biochemical method. Finally, we have demonstrated the synergistic activity of TTPB with kanamycin. Results: For the first time, the hydrolytic activity of TTPB towards bacterial EPSs has been shown. TTPB releases about a half of the whole RS amount of EPSs belonging to K. pneumoniae PCM 2713 and E. cloacae ATCC 13047 strains. 1.12 &micro;M of the phage protein reduces biofilm of both strains by over 60%. Destroying the bacterial biofilm the phage protein improves the antibiotic action increasing kanamycin effectiveness up to four times.

Actions antibiotique, mycolytique et parasitaire de deux actinomycètes envers Fusarium oxysporum f.sp. albedinis et autres formae speciales

1983 ◽  
Vol 29 (2) ◽  
pp. 194-199 ◽  
Author(s):  
Nasserdine Sabaou ◽  
Nicole Bounaga ◽  
Djilali Bounaga
Keyword(s):  
Fusarium Oxysporum ◽  
Fungal Mycelium ◽  
Antagonistic Action ◽  
Genus Streptomyces ◽  
Streptomyces Strain ◽  
Formae Speciales ◽  
Antibiotic Action

Two actinomycètes (X9 and X10) isolated on a Fusarium oxysporum f.sp. albedinis strain showed antibiotic, mycolytic, and parasitism actions against nine "formae speciales" of Fusarium oxysporum. Strain X10 is included in genus Streptomyces and strain X9 in Nocardiopsis dassonvillei species (Lechevalier and Lechevalier) Meyer. The antibiotic action of Streptomyces strain is stronger towards F. o. dianthi, F. o. albedinis, and F. o. cyclaminis. It seems that the mycolytic power of N. dassonvillei is more specific to F. o. eleaidis, whereas the parasitism action varies depending on the "formae speciales" tested and the quantity of fungal mycelium produced. As a response to this parasitism, all the fungi produce resistance organs that can either be polymorphous thallospores or chlamydospores. The thallospores studied on a F. o. albedinis strain germinate faster than the microconidies of the same nonparasited fungus. However, many strains obtained from these thallospores are as susceptible as the mother strain to the antagonistic action of both actinomycetes

scholarly journals Studies on the Antibiotic Action of Fish Components-V

1954 ◽  
Vol 19 (9) ◽  
pp. 963-967
Author(s):  
Yukio TOMIYASU ◽  
Masamichi TOYOMIZU
Keyword(s):  
Antibiotic Action

scholarly journals On the Antibiotic Action of Unsaturated Ketones

1952 ◽  
Vol 26 (2) ◽  
pp. 61-64
Author(s):  
N. ITO ◽  
K. MORI ◽  
M. WATANABE
Keyword(s):  
Unsaturated Ketones ◽  
Antibiotic Action

Antibiotic Action of β-Lapachone againstSalmonella: Effects on Respiratory Chain Functions

Planta Medica ◽  
1992 ◽  
Vol 58 (S 1) ◽  
pp. 633-634
Author(s):  
A. Wildpret ◽  
L. Moujir ◽  
A. Ravelo ◽  
A. Gutiérrez-Navarro
Keyword(s):  
Respiratory Chain ◽  
Antibiotic Action
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