scholarly journals A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse model

2007 ◽  
Vol 3 (1) ◽  
pp. 112 ◽  
Author(s):  
François‐Pierre J Martin ◽  
Marc‐Emmanuel Dumas ◽  
Yulan Wang ◽  
Cristina Legido‐Quigley ◽  
Ivan K S Yap ◽  
...  
Keyword(s):  
Systems Biology ◽  
Mouse Model ◽  
Top Down ◽  
Metabolic Interactions

scholarly journals Top‐down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model

2008 ◽  
Vol 4 (1) ◽  
pp. 205 ◽  
Author(s):  
Francois‐Pierre J Martin ◽  
Yulan Wang ◽  
Norbert Sprenger ◽  
Ivan K S Yap ◽  
Serge Rezzi ◽  
...  
Keyword(s):  
Systems Biology ◽  
Mouse Model ◽  
Top Down

Data Analysis and Interpretation in Metabolomics

2013 ◽  
pp. 1494-1521
Author(s):  
Jose M. Garcia-Manteiga
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Data Analysis ◽  
Systems Biology ◽  
Magnetic Resonance ◽  
Biological System ◽  
Analytical Techniques ◽  
Point Of View ◽  
The Other ◽  
Top Down

Metabolomics represents the new ‘omics’ approach of the functional genomics era. It consists in the identification and quantification of all small molecules, namely metabolites, in a given biological system. While metabolomics refers to the analysis of any possible biological system, metabonomics is specifically applied to disease and physiopathological situations. The data collected within these approaches is highly integrative of the other higher levels and is hence amenable to be explored with a top-down systems biology point of view. The aim of this chapter is to give a global view of the state of the art in metabolomics describing the two analytical techniques usually used to give rise to this kind of data, nuclear magnetic resonance, NMR, and mass spectrometry. In addition, the author will focus on the different data analysis tools that can be applied to such studies to extract information with special interest at the attempts to integrate metabolomics with other ‘omics’ approaches and its relevance in systems biology modeling.

Data Analysis and Interpretation in Metabolomics

2011 ◽  
pp. 29-56
Author(s):  
Jose M. Garcia-Manteiga
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Magnetic Resonance ◽  
Data Analysis ◽  
Systems Biology ◽  
Magnetic Resonance ◽  
Biological System ◽  
Analytical Techniques ◽  
Point Of View ◽  
The Other ◽  
Top Down

Metabolomics represents the new ‘omics’ approach of the functional genomics era. It consists in the identification and quantification of all small molecules, namely metabolites, in a given biological system. While metabolomics refers to the analysis of any possible biological system, metabonomics is specifically applied to disease and physiopathological situations. The data collected within these approaches is highly integrative of the other higher levels and is hence amenable to be explored with a top-down systems biology point of view. The aim of this chapter is to give a global view of the state of the art in metabolomics describing the two analytical techniques usually used to give rise to this kind of data, nuclear magnetic resonance, NMR, and mass spectrometry. In addition, the author will focus on the different data analysis tools that can be applied to such studies to extract information with special interest at the attempts to integrate metabolomics with other ‘omics’ approaches and its relevance in systems biology modeling.

19.1 NEUROIMMUNE, EPIGENETIC, AND METABOLIC INTERACTIONS DURING SYMPTOM PROGRESSION IN A MOUSE MODEL OF RETT SYNDROME

2020 ◽  
Vol 59 (10) ◽  
pp. S294
Author(s):  
Janine M. LaSalle ◽  
Dag H. Yasui ◽  
Kari E. Neier ◽  
Sharifi Osman ◽  
Annie Vogel Ciernia ◽  
...  
Keyword(s):  
Mouse Model ◽  
Rett Syndrome ◽  
Metabolic Interactions ◽  
Symptom Progression

Top-Down Systems Biology Modeling of Host Metabotype−Microbiome Associations in Obese Rodents

2009 ◽  
Vol 8 (5) ◽  
pp. 2361-2375 ◽  
Author(s):  
Alison Waldram ◽  
Elaine Holmes ◽  
Yulan Wang ◽  
Mattias Rantalainen ◽  
Ian D. Wilson ◽  
...  
Keyword(s):  
Systems Biology ◽  
Top Down

scholarly journals Alteration of glial-neuronal metabolic interactions in a mouse model of Alexander disease

Glia ◽  
2010 ◽  
Vol 58 (10) ◽  
pp. 1228-1234 ◽  
Author(s):  
Tore Wergeland Meisingset ◽  
Øystein Risa ◽  
Michael Brenner ◽  
Albee Messing ◽  
Ursula Sonnewald
Keyword(s):  
Mouse Model ◽  
Alexander Disease ◽  
Metabolic Interactions

scholarly journals A metabolomic and systems biology perspective on the brain of the Fragile X syndrome mouse model

2011 ◽  
Vol 21 (12) ◽  
pp. 2190-2202 ◽  
Author(s):  
L. Davidovic ◽  
V. Navratil ◽  
C. M. Bonaccorso ◽  
M. V. Catania ◽  
B. Bardoni ◽  
...  
Keyword(s):  
Systems Biology ◽  
Mouse Model ◽  
Fragile X Syndrome ◽  
Fragile X ◽  
The Brain
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