scholarly journals Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis

2007 ◽  
Vol 3 (1) ◽  
pp. 99 ◽  
Author(s):  
Jacob D Feala ◽  
Laurence Coquin ◽  
Andrew D McCulloch ◽  
Giovanni Paternostro
Keyword(s):  
Energy Metabolism ◽  
Systems Analysis ◽  
Flight Muscle ◽  
Hypoxia Tolerance ◽  
Computational Systems

scholarly journals IMMUNOFLUORESCENT LOCALIZATION OF TWO DEHYDROGENASES IN HONEYBEE FLIGHT MUSCLE

1972 ◽  
Vol 20 (4) ◽  
pp. 266-271 ◽  
Author(s):  
RONALD W. BROSEMER
Keyword(s):  
Energy Metabolism ◽  
Flight Muscle ◽  
Immunofluorescent Localization ◽  
Glycerol 3 Phosphate Dehydrogenase

Two enzymes involved in energy metabolism, glycerol-3-phosphate dehydrogenase and triosephosphate dehydrogenase, were localized in honeybee flight muscle with immunofluorescent techniques. Both enzymes were found at or near the Z-band cross-striations.

scholarly journals Computational Systems Analysis of Dopamine Metabolism

PLoS ONE ◽  
2008 ◽  
Vol 3 (6) ◽  
pp. e2444 ◽  
Author(s):  
Zhen Qi ◽  
Gary W. Miller ◽  
Eberhard O. Voit
Keyword(s):  
Systems Analysis ◽  
Dopamine Metabolism ◽  
Computational Systems

scholarly journals A computational systems analysis of factors regulating α cell glucagon secretion

Islets ◽  
2012 ◽  
Vol 4 (4) ◽  
pp. 262-283 ◽  
Author(s):  
Leonid E. Fridlyand ◽  
Louis H. Philipson
Keyword(s):  
Systems Analysis ◽  
Glucagon Secretion ◽  
Computational Systems

scholarly journals Naked mole-rats suppress energy metabolism and modulate membrane cholesterol in chronic hypoxia

2020 ◽  
Vol 319 (2) ◽  
pp. R148-R155
Author(s):  
Elie Farhat ◽  
Maiah E. M. Devereaux ◽  
Matthew E. Pamenter ◽  
Jean-Michel Weber
Keyword(s):  
Energy Metabolism ◽  
Metabolic Rate ◽  
Chronic Hypoxia ◽  
Membrane Lipids ◽  
Tca Cycle ◽  
Hypoxia Tolerance ◽  
Membrane Cholesterol ◽  
Functional Link ◽  
Sodium Potassium ◽  
Potassium Atpase

Naked mole-rats (NMRs) are mammalian champions of hypoxia tolerance that enter metabolic suppression to survive in low oxygen environments. Common physiological mechanisms used by animals to suppress metabolic rate include downregulating energy metabolism (ATP supply) as well as ion pumps (primary cellular ATP consumers). A recent goldfish study demonstrated that remodeling of membrane lipids may mediate these responses, but it is unknown if NMR employs the same strategies; therefore, we aimed to test the hypotheses that these fossorial mammals 1) downregulate the activity of key enzymes of glycolysis, tricarboxylic acid (TCA) cycle, and β-oxidation, 2) inhibit sodium-potassium-ATPase, and 3) alter membrane lipids in response to chronic hypoxia. We found that NMRs exposed to 11% oxygen for 4 wk had a lower metabolic rate by 34%. This suppression occurs concurrently with tissue-specific 25–99% decreases in metabolic enzymes activities, a 77% decrease in brain sodium/potassium-ATPase activity, and widespread changes in membrane cholesterol abundance. By reducing glycolytic and β-oxidation fluxes, NMRs decrease the supply of acetyl-CoA to the TCA cycle. By contrast, there is a 94% upregulation of citrate synthase in the heart, possibly to support circulation and thus oxygen supply to other organs. Taken together, these responses may reflect a coordinated physiological response to hypoxia, but a clear functional link between changes in membrane composition and enzyme activities could not be established. Nevertheless, this is the first demonstration that hypometabolic NMRs alter the lipid composition of their membranes in response to chronic in vivo exposure to hypoxia.

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