scholarly journals Widespread splicing changes in human brain development and aging

2013 ◽  
Vol 9 (1) ◽  
pp. 633 ◽  
Author(s):  
Pavel Mazin ◽  
Jieyi Xiong ◽  
Xiling Liu ◽  
Zheng Yan ◽  
Xiaoyu Zhang ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Human Brain Development ◽  
Development And Aging

scholarly journals Coordination of Gene Expression of Arachidonic and Docosahexaenoic Acid Cascade Enzymes during Human Brain Development and Aging

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100858 ◽  
Author(s):  
Veronica H. Ryan ◽  
Christopher T. Primiani ◽  
Jagadeesh S. Rao ◽  
Kwangmi Ahn ◽  
Stanley I. Rapoport ◽  
...  
Keyword(s):  
Gene Expression ◽  
Docosahexaenoic Acid ◽  
Human Brain ◽  
Brain Development ◽  
Human Brain Development ◽  
Development And Aging

Gangliosides in the human brain development and aging

1992 ◽  
Vol 20 (3) ◽  
pp. 421-431 ◽  
Author(s):  
Ivica Kracun ◽  
Harald Rosner ◽  
Valerija Drnovsek ◽  
Zeljka Vukelic ◽  
Cedomir Cosovic ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Human Brain Development ◽  
Development And Aging

scholarly journals Longitudinal data for magnetic susceptibility of normative human brain development and aging over the lifespan

Data in Brief ◽  
2018 ◽  
Vol 20 ◽  
pp. 623-631 ◽  
Author(s):  
Yuyao Zhang ◽  
Hongjiang Wei ◽  
Matthew J. Cronin ◽  
Naying He ◽  
Fuhua Yan ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Longitudinal Data ◽  
Human Brain ◽  
Brain Development ◽  
Human Brain Development ◽  
Development And Aging

scholarly journals §Using organoids to study human brain development and evolution

2021 ◽  
Author(s):  
Wai‐Kit Chan ◽  
Rana Fetit ◽  
Rosie Griffiths ◽  
Helen Marshall ◽  
John O Mason ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Human Brain Development ◽  
Development And Evolution

scholarly journals Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia

2021 ◽  
Author(s):  
Ugomma C. Eze ◽  
Aparna Bhaduri ◽  
Maximilian Haeussler ◽  
Tomasz J. Nowakowski ◽  
Arnold R. Kriegstein
Keyword(s):  
Human Brain ◽  
Brain Development ◽  
Single Cell ◽  
Radial Glia ◽  
Cortical Development ◽  
Cell Types ◽  
Human Cortex ◽  
Early Stages ◽  
Human Brain Development ◽  
Neuroepithelial Cells

AbstractThe human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex. To characterize the earliest stages of human brain development, we performed single-cell RNA-sequencing across regions of the developing human brain, including the telencephalon, diencephalon, midbrain, hindbrain and cerebellum. We identify nine progenitor populations physically proximal to the telencephalon, suggesting more heterogeneity than previously described, including a highly prevalent mesenchymal-like population that disappears once neurogenesis begins. Comparison of human and mouse progenitor populations at corresponding stages identifies two progenitor clusters that are enriched in the early stages of human cortical development. We also find that organoid systems display low fidelity to neuroepithelial and early radial glia cell types, but improve as neurogenesis progresses. Overall, we provide a comprehensive molecular and spatial atlas of early stages of human brain and cortical development.

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