scholarly journals Ultrasensitive gene regulation by positive feedback loops in nucleosome modification

2008 ◽  
Vol 4 (1) ◽  
pp. 182 ◽  
Author(s):  
Kim Sneppen ◽  
Mille A Micheelsen ◽  
Ian B Dodd
Keyword(s):  
Gene Regulation ◽  
Positive Feedback ◽  
Feedback Loops

scholarly journals FGF2 Translationally Induced by Hypoxia Is Involved in Negative and Positive Feedback Loops with HIF-1α

PLoS ONE ◽  
2008 ◽  
Vol 3 (8) ◽  
pp. e3078 ◽  
Author(s):  
Caroline Conte ◽  
Elodie Riant ◽  
Céline Toutain ◽  
Françoise Pujol ◽  
Jean-François Arnal ◽  
...  
Keyword(s):  
Positive Feedback ◽  
Feedback Loops

scholarly journals Understanding MAPK Signaling Pathways in Apoptosis

2020 ◽  
Vol 21 (7) ◽  
pp. 2346 ◽  
Author(s):  
Jicheng Yue ◽  
José M. López
Keyword(s):  
Signaling Pathways ◽  
Positive Feedback ◽  
Cell Model ◽  
Mapk Signaling ◽  
Feedback Loops ◽  
Mitogen Activated Protein Kinase ◽  
Cellular Mechanisms ◽  
Mitogen Activated Protein ◽  
Induced Apoptosis ◽  
Mapk Signaling Pathways

MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or inhibitors, depending on the cell type and the stimulus. In this review, we present the main pro- and anti-apoptotic mechanisms regulated by MAPKs, as well as the crosstalk observed between some MAPKs. We also describe the basic signaling properties of MAPKs (ultrasensitivity, hysteresis, digital response), and the presence of different positive feedback loops in apoptosis. We provide a simple guide to predict MAPKs’ behavior, based on the intensity and duration of the stimulus. Finally, we consider the role of MAPKs in osmostress-induced apoptosis by using Xenopus oocytes as a cell model. As we will see, apoptosis is plagued with multiple positive feedback loops. We hope this review will help to understand how MAPK signaling pathways engage irreversible cellular decisions.

scholarly journals Digital signaling network drives the assembly of the AIM2-ASC inflammasome

2018 ◽  
Vol 115 (9) ◽  
pp. E1963-E1972 ◽  
Author(s):  
Mariusz Matyszewski ◽  
Seamus R. Morrone ◽  
Jungsan Sohn
Keyword(s):  
Host Defense ◽  
Positive Feedback ◽  
Signal Amplification ◽  
Molecular Level ◽  
Design Principles ◽  
Digital Circuit ◽  
Quantitative Model ◽  
Feedback Loops ◽  
Signaling Network

The AIM2-ASC inflammasome is a filamentous signaling platform essential for mounting host defense against cytoplasmic dsDNA arising not only from invading pathogens but also from damaged organelles. Currently, the design principles of its underlying signaling network remain poorly understood at the molecular level. We show here that longer dsDNA is more effective in inducing AIM2 assembly, its self-propagation, and downstream ASC polymerization. This observation is related to the increased probability of forming the base of AIM2 filaments, and indicates that the assembly discerns small dsDNA as noise at each signaling step. Filaments assembled by receptor AIM2, downstream ASC, and their joint complex all persist regardless of dsDNA, consequently generating sustained signal amplification and hysteresis. Furthermore, multiple positive feedback loops reinforce the assembly, as AIM2 and ASC filaments accelerate the assembly of nascent AIM2 with or without dsDNA. Together with a quantitative model of the assembly, our results indicate that an ultrasensitive digital circuit drives the assembly of the AIM2-ASC inflammasome.

scholarly journals Walking pathways with positive feedback loops reveal DNA methylation biomarkers of colorectal cancer

2019 ◽  
Vol 20 (S4) ◽  
Author(s):  
Alexander Kel ◽  
Ulyana Boyarskikh ◽  
Philip Stegmaier ◽  
Leonid S. Leskov ◽  
Andrey V. Sokolov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Positive Feedback ◽  
Feedback Loops

Cancerous perturbations within the ERK, PI3K/Akt, and Wnt/β-catenin signaling network constitutively activate inter-pathway positive feedback loops

2017 ◽  
Vol 13 (5) ◽  
pp. 830-840 ◽  
Author(s):  
Rahul Rao Padala ◽  
Rishabh Karnawat ◽  
Satish Bharathwaj Viswanathan ◽  
Abhishek Vijay Thakkar ◽  
Asim Bikas Das
Keyword(s):  
Signaling Pathways ◽  
Malignant Transformation ◽  
Positive Feedback ◽  
Feedback Loops ◽  
Signaling Network ◽  
Molecular Signaling ◽  
Activated State ◽  
Molecular Signaling Pathways

Perturbations in molecular signaling pathways result in a constitutively activated state, leading to malignant transformation of cells.

The Analysis of Economic and Environmental Feedback System and Proposed Management Policies in Jiuzhaigou

2012 ◽  
Vol 573-574 ◽  
pp. 251-255
Author(s):  
Qi Sheng Chen ◽  
Peng Ge ◽  
Pei Yu Ren
Keyword(s):  
Sustainable Development ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Feedback System ◽  
Feedback Loops ◽  
System Dynamics Model ◽  
Dynamics Model ◽  
The Sustainable Development ◽  
Scenic Spot ◽  
Management Policies

Jiuzhaigou scenic spot (Jiuzhaigou) is an ecological and economic system. The constraints and feedbacks between the economic subsystem and environmental subsystem are very important to the sustainable development. To study this system, the paper creates the system dynamics model about the constraints and feedbacks between economic subsystem and environmental subsystem. The model is made of one growth positive feedback loop of tourism development and two confine positive feedback loops of space constraint and pollution constraint. Then the paper brings up sustainable development management policies in Jiuzhaigou.

Sign in / Sign up

Export Citation Format

Share Document