scholarly journals Extinction of auditory threat memory triggers activation of p70 S6 kinase 1 in the basolateral nucleus of the amygdala

2018 ◽  
Vol 23 (6) ◽  
pp. 1393-1393
Author(s):  
T N Huynh ◽  
E Santini ◽  
E Mojica ◽  
A E Fink ◽  
B S Hall ◽  
...  
Keyword(s):  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Basolateral Nucleus

Inhibition of p70 S6 kinase by rapamycin does not reverse the activated phenotype of pancreatic stellate cells

2001 ◽  
Vol 120 (5) ◽  
pp. A720
Author(s):  
Brent A. Neuschwander-Tetri ◽  
Lin Li ◽  
Lisa D. Wells ◽  
Bruce R. Bacon ◽  
Robert S. Britton
Keyword(s):  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
S6 Kinase ◽  
P70 S6 Kinase

Troglitazone acutely inhibits protein synthesis in endothelial cells via a novel mechanism involving protein phosphatase 2A-dependent p70 S6 kinase inhibition

2006 ◽  
Vol 291 (2) ◽  
pp. C317-C326 ◽  
Author(s):  
Du-Hyong Cho ◽  
Yoon Jung Choi ◽  
Sangmee Ahn Jo ◽  
Jungsang Ryou ◽  
Jin Yi Kim ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Protein Synthesis ◽  
Protein Phosphatase ◽  
Protein Phosphatase 2A ◽  
Peroxisome Proliferator ◽  
Inhibitory Effects ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Inhibition Of Protein Synthesis ◽  
Phosphatase 2A

Thiazolidinediones (TZDs), synthetic peroxisome proliferator-activated receptor γ (PPARγ) ligands, have been implicated in the inhibition of protein synthesis in a variety of cells, but the underlying mechanisms remain obscure. We report that troglitazone, the first TZD drug, acutely inhibited protein synthesis by decreasing p70 S6 kinase (p70S6K) activity in bovine aortic endothelial cells (BAEC). This inhibition was not accompanied by decreased phosphorylation status or in vitro kinase activity of mammalian target of rapamycin (mTOR). Furthermore, cotreatment with rapamycin, a specific mTOR inhibitor, and troglitazone additively inhibited both p70S6K activity and protein synthesis, suggesting that the inhibitory effects of troglitazone are not mediated by mTOR. Overexpression of the wild-type p70S6K gene significantly reversed the troglitazone-induced inhibition of protein synthesis, indicating an important role of p70S6K. Okadaic acid, a protein phosphatase 2A (PP2A) inhibitor, partially reversed the troglitazone-induced inhibition of p70S6K activity and protein synthesis. Although troglitazone did not alter total cellular PP2A activity, it increased the physical association between p70S6K and PP2A, suggesting an underlying molecular mechanism. GW9662, a PPARγ antagonist, did not alter any of the observed inhibitory effects. Finally, we also found that the mTOR-independent inhibitory mechanism of troglitazone holds for the TZDs ciglitazone, pioglitazone, and rosiglitazone, in BAEC and other types of endothelial cells tested. In conclusion, our data demonstrate for the first time that troglitazone (and perhaps other TZDs) acutely decreases p70S6K activity through a PP2A-dependent mechanism that is independent of mTOR and PPARγ, leading to the inhibition of protein synthesis in endothelial cells.

scholarly journals Suppression by HSP90 inhibitors of BMP-4-stimulated osteoprotegerin synthesis in osteoblasts: Attenuation of p70 S6 kinase

2017 ◽  
Vol 16 (6) ◽  
pp. 8507-8512 ◽  
Author(s):  
Tetsu Kawabata ◽  
Takanobu Otsuka ◽  
Kazuhiko Fujita ◽  
Shingo Kainuma ◽  
Naohiro Yamamoto ◽  
...  
Keyword(s):  
Hsp90 Inhibitors ◽  
S6 Kinase ◽  
P70 S6 Kinase

scholarly journals AMPD1 regulates insulin sensitivity through AMPK/mTOR/p70 S6 kinase signaling pathway in skeletal muscles

2015 ◽  
Vol 39 (1) ◽  
pp. 72
Author(s):  
Andreas Avellini K Tandelilin ◽  
Tetsuaki Hirase ◽  
Athanasius Wrin Hudoyo ◽  
Jidong Cheng ◽  
Hiroko Morisaki ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Signaling Pathway ◽  
Skeletal Muscles ◽  
Kinase Signaling ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Kinase Signaling Pathway

scholarly journals Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

2012 ◽  
Vol 109 (40) ◽  
pp. 16184-16189 ◽  
Author(s):  
J. L. Owen ◽  
Y. Zhang ◽  
S.-H. Bae ◽  
M. S. Farooqi ◽  
G. Liang ◽  
...  
Keyword(s):  
Rat Hepatocytes ◽  
Transgenic Rat ◽  
Insulin Stimulation ◽  
S6 Kinase ◽  
P70 S6 Kinase ◽  
Stimulation Of
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