scholarly journals Genetic contributions to self-reported tiredness

2017 ◽  
Vol 23 (3) ◽  
pp. 609-620 ◽  
Author(s):  
V Deary ◽  
◽  
S P Hagenaars ◽  
S E Harris ◽  
W D Hill ◽  
...  
Keyword(s):  
Mental Health ◽  
Smoking Status ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Physical And Mental Health ◽  
C Reactive Protein ◽  
Major Depressive ◽  
Reactive Protein ◽  
Genome Wide

Abstract Self-reported tiredness and low energy, often called fatigue, are associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6 and 50%. In the UK Biobank sample (N=108 976), we carried out a genome-wide association study (GWAS) of responses to the question, ‘Over the last two weeks, how often have you felt tired or had little energy?’ Univariate GCTA-GREML found that the proportion of variance explained by all common single-nucleotide polymorphisms for this tiredness question was 8.4% (s.e.=0.6%). GWAS identified one genome-wide significant hit (Affymetrix id 1:64178756_C_T; P=1.36 × 10−11). Linkage disequilibrium score regression and polygenic profile score analyses were used to test for shared genetic aetiology between tiredness and up to 29 physical and mental health traits from GWAS consortia. Significant genetic correlations were identified between tiredness and body mass index (BMI), C-reactive protein, high-density lipoprotein (HDL) cholesterol, forced expiratory volume, grip strength, HbA1c, longevity, obesity, self-rated health, smoking status, triglycerides, type 2 diabetes, waist–hip ratio, attention deficit hyperactivity disorder, bipolar disorder, major depressive disorder, neuroticism, schizophrenia and verbal-numerical reasoning (absolute r g effect sizes between 0.02 and 0.78). Significant associations were identified between tiredness phenotypic scores and polygenic profile scores for BMI, HDL cholesterol, low-density lipoprotein cholesterol, coronary artery disease, C-reactive protein, HbA1c, height, obesity, smoking status, triglycerides, type 2 diabetes, waist–hip ratio, childhood cognitive ability, neuroticism, bipolar disorder, major depressive disorder and schizophrenia (standardised β’s had absolute values<0.03). These results suggest that tiredness is a partly heritable, heterogeneous and complex phenomenon that is phenotypically and genetically associated with affective, cognitive, personality and physiological processes.

scholarly journals Genetic contributions to self-reported tiredness

2016 ◽  
Author(s):  
Vincent Deary ◽  
Saskia P Hagenaars ◽  
Sarah E Harris ◽  
W David Hill ◽  
Gail Davies ◽  
...  
Keyword(s):  
Mental Health ◽  
Type 2 Diabetes ◽  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Smoking Status ◽  
Hdl Cholesterol ◽  
Physical And Mental Health ◽  
Major Depressive ◽  
Genome Wide

Self-reported tiredness and low energy, often called fatigue, is associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6% and 50%. In the UK Biobank sample (N = 108 976) we carried out a genome-wide association study of responses to the question, ″Over the last two weeks, how often have you felt tired or had little energy?″ Univariate GCTA-GREML found that the proportion of variance explained by all common SNPs for this tiredness question was 8.4% (SE = 0.6%). GWAS identified one genome-wide significant hit (Affymetrix id 1:64178756_C_T; p = 1.36 x 10-11). LD score regression and polygenic profile analysis were used to test for pleiotropy between tiredness and up to 28 physical and mental health traits from GWAS consortia. Significant genetic correlations were identified between tiredness and BMI, HDL cholesterol, forced expiratory volume, grip strength, HbA1c, longevity, obesity, self-rated health, smoking status, triglycerides, type 2 diabetes, waist-hip ratio, ADHD, bipolar disorder, major depressive disorder, neuroticism, schizophrenia, and verbal-numerical reasoning (absolute rg effect sizes between 0.11 and 0.78). Significant associations were identified between tiredness phenotypic scores and polygenic profile scores for BMI, HDL cholesterol, LDL cholesterol, coronary artery disease, HbA1c, height, obesity, smoking status, triglycerides, type 2 diabetes, and waist-hip ratio, childhood cognitive ability, neuroticism, bipolar disorder, major depressive disorder, and schizophrenia (standardised β′s between -0.016 and 0.03). These results suggest that tiredness is a partly-heritable, heterogeneous and complex phenomenon that is phenotypically and genetically associated with affective, cognitive, personality, and physiological processes.

scholarly journals Chosen Vascular Risk Markers in Pseudoexfoliation Syndrome: An Age-Related Disorder

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Hanna Lesiewska ◽  
Agnieszka Łukaszewska-Smyk ◽  
Grażyna Odrowąż-Sypniewska ◽  
Magdalena Krintus ◽  
Aneta Mańkowska-Cyl ◽  
...  
Keyword(s):  
Density Lipoprotein ◽  
Vascular Diseases ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Serum Levels ◽  
Pseudoexfoliation Syndrome ◽  
C Reactive Protein ◽  
Related Disorder ◽  
Reactive Protein ◽  
Age Related

Purpose. To evaluate lipids and C-reactive protein serum levels in patients with pseudoexfoliation syndrome (PEX) in the Polish population. Methods. 96 patients were studied with PEX and 79 control subjects. Total cholesterol, triglycerides, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, non-HDL-cholesterol and CRP serum levels, and TG/HDL-C and TC/HDL-C indexes were assessed. Results. There were no significant differences in concentration of lipids and values of TC/HDL-C, TG/HDL-C, and non-HDL-C between PEX and control groups. High-sensitivity C-reactive protein was not increased in patients with PEX. Conclusions. Our results cast doubt on the opinion on the possible PEX and vascular diseases relation. Further studies on this subject are mandatory.

scholarly journals Effects of Subtypes of Child Maltreatment on CRP in Adulthood

2021 ◽  
Vol 12 ◽  
Author(s):  
Vicki Bitsika ◽  
Christopher F. Sharpley ◽  
Mary E. McMillan ◽  
Emmanuel Jesulola ◽  
Linda L. Agnew
Keyword(s):  
Mental Health ◽  
Childhood Maltreatment ◽  
Life Stress ◽  
Specific Aspect ◽  
Self Report ◽  
Physical And Mental Health ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Depression Status ◽  
Rural Australia

In order to evaluate the effects of specific forms of childhood maltreatment (CM) upon adult C-reactive protein (CRP) concentrations, and to further describe the potentially confounding role that recent life stress and depression hold in that relationship, 221 participants from rural Australia (M age = 44yr, SD = 17.8yr) completed self-report questionnaires and provided a blood sample. There were no sex differences in any variables across the 91 males and 130 females, but depression status did confound the association between global CM and CRP. The specific aspect of CM was identified as physical and mental health abuse, and this was significantly associated with CRP level in participants with depressive symptoms and those without. There was no significant confound from recent life stressors. Results hold implications for the diagnosis of CM-related CRP elevation and (potentially) depression.

scholarly journals Association of Clinical Characteristics with the Proportion of the HDL-Cholesterol Subclasses HDL-2b and HDL-3 Among Patients Undergoing Hemodialysis

2020 ◽  
Author(s):  
Jin-Bor Chen ◽  
Wen-Chin Lee ◽  
Sin-Hua Moi ◽  
Cheng-Hong Yang
Keyword(s):  
Clinical Characteristics ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Healthy Individuals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Diabetic Status ◽  
The Mean ◽  
Hs Crp

Abstract Background: Altered high-density lipoprotein cholesterol (HDL-C) composition in patients with chronic kidney disease is common. However, reports on the distribution of HDL-C subclasses in patients undergoing hemodialysis (HD) are limited. Objective: We aimed to compare the two main HDL-C subclasses, HDL-2b and HDL-3, in two cohorts of HD patients and healthy individuals and examine their associations with clinical characteristics. Methods: A total of 164 prevalent HD patients and 71 healthy individuals in one hospital-facilitated outpatient clinic were enrolled from May 2019 to July 2019. The HDL-2b and HDL-3 proportions were measured and statistical analysis was performed. Results: The mean ages of HD patients and healthy individuals were 63 and 49.9 years, respectively. HD patients showed lower HDL-2b and HDL-3 proportions compared with those of healthy individuals (23.6% vs. 31.2%, P < 0.001; 31.7% vs. 33.6%, P = 0.137, respectively). The HDL-2b proportion was significantly higher with a high-sensitivity C-reactive protein (hs-CRP) levels of <3 mg/L compared with hs-CRP ≥3mg/L in the HD cohort (P = 0.005). HDL-3 proportion was lower with a hs-CRP level of <3 mg/L compared with hs-CRP ≥3mg/L in the HD cohort (P = 0.022). Sex and diabetes did not influence the HDL-2b and HDL-3 proportions in the HD cohort.Conclusions: HD patients had lower HDL-2b and HDL-3 proportions than those of healthy individuals. The distribution of the HDL-2b and HDL-3 subclasses in HD patients is influenced by proinflammatory status, not by sex and diabetic status.

Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels

2011 ◽  
Vol 106 (12) ◽  
pp. 1170-1178 ◽  
Author(s):  
Dan Ryan ◽  
Arthur Moss ◽  
Jeanette McCarthy ◽  
Ilan Goldenberg ◽  
Wojciech Zareba ◽  
...  
Keyword(s):  
Recurrent Events ◽  
Vascular Inflammation ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Matricellular Protein ◽  
Human Populations ◽  
C Reactive Protein ◽  
Cvd Risk ◽  
Reactive Protein ◽  
Thrombospondin 4

SummaryFew studies are available in human populations investigating involvement of vascular inflammation and oxidative stress-related dysfunctional transformation of high-density lipoprotein (HDL) in establishing cardiovascular disease (CVD) risk. To this end, the current work investigated a subgroup of post-infarction patients at high-risk for recurrent events defined by high levels of HDL cholesterol (HDL-C) and concurrently high levels of C-reactive protein (CRP). Thrombospondin-4 (TSP-4), a matricellular protein of vessel walls associated with inflammation, was investigated in terms of CVD risk using multivariable modelling with a well-characterised functional genetic polymorphism of THBS4 (A387P, rs1866389) along with previously demonstrated risk-related functional genetic polymorphisms of CYBA (C242T, rs4673) and CETP (TaqIB, rs708272), and a set of blood markers. Results revealed risk-association for the gain-of-function P-allele of the THBS4 polymorphism (hazard ratio 2.00, 95% confidence interval 1.10–3.65, p=0.024). Additionally, von Willebrand factor was associated with D-dimer levels in the higher-risk P allele patients suggestive of a connection between endothelial dysfunction and thrombogenesis. In conclusion, TSP-4, a matricellular protein involved in regulating vascular inflammation, plays a role in establishing recurrent coronary risk in postinfarction patients with high levels of HDL-C and CRP. Further studies should focus on additional effects of vascular inflammatory processes on anti-atherogenic functionality of HDL particles.

scholarly journals Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients

2018 ◽  
Vol 25 (4) ◽  
pp. 357-362
Author(s):  
Nartyr Sunarti ◽  
Sri Lestari Sulistyo Rini ◽  
Hemi Sinorita ◽  
Dini Ariani
Keyword(s):  
Type 2 Diabetes ◽  
Hdl Cholesterol ◽  
Atherogenic Index ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Before And After ◽  
Positive Effect ◽  
Hba1c Levels ◽  
Diabetes Patients

Abstract Background and aims: High levels of non-HDL and atherogenic cholesterol can induce inflammation, and as risk factor for cardiovascular diseases. This study was to evaluate the effects of fiber-rich snacks on non-HDL cholesterol, atherogenic index, and Creactive protein (CRP) levels in type 2 diabetes patients (T2DM). Material and Methods: Twenty T2DM patients, were recruited from the Policlinic of Endocrine, Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The subjects received daily 32g fiber-rich snacks made of Dioscorea esculenta, arrowroot, cassava and pumpkin for 4 weeks. Fasting non-HDL cholesterol, atherogenic index, CRP and HbA1c levels were measured before and after intervention. Paired t-test was used to evaluate the results. Results: The fiber-rich snack intervention in T2DM patients significantly reduced levels of non-HDL cholesterol and CRP levels (p<0.05), but the decreased the atherogenic index was not significant (p>0.05). The intervention also significantly reduced the CRP levels (p<0.05) but did not affect HbA1c levels. Body weight, body mass index (BMI), waist circumference decreased significantly after consuming the snacks (p<0.05). Conclusions: This study showed fiber-rich snack has a positive effect in improving non-HDL cholesterol, atherogenic index and CRP levels but does not affect HbA1c levels in T2DM patients.

scholarly journals Plasma Anthranilic Acid and Leptin Levels Predict HAM-D Scores in Depressed Women

2021 ◽  
Vol 14 ◽  
pp. 117864692110164
Author(s):  
Johann Steiner ◽  
Henrik Dobrowolny ◽  
Paul C Guest ◽  
Hans-Gert Bernstein ◽  
Dietmar Fuchs ◽  
...  
Keyword(s):  
Depression Severity ◽  
C Reactive Protein ◽  
Major Depressive ◽  
Genome Wide Analysis ◽  
Reactive Protein ◽  
Genome Wide ◽  
Drug Naïve ◽  
Male Patients ◽  
Highly Correlated ◽  
Gender Specific

Objectives: Major depressive disorder (MDD) is associated with dysregulations of leptin and tryptophan–kynurenine (Trp–Kyn) (TKP) pathways. Leptin, a pro-inflammatory cytokine, activates Trp conversion into Kyn. However, leptin association with down-stream Kyn metabolites in MDD is unknown. Methods: Fasting plasma samples from 29 acutely ill drug-naïve (n = 16) or currently non-medicated (⩾6 weeks; n = 13) MDD patients were analyzed for leptin, Trp, Kyn, its down-stream metabolites (anthranilic [AA], kynurenic [KYNA], xanthurenic [XA] acids and 3-hydroxykynurenine [3HK]), C-reactive protein (CRP), neopterin, body mass index (BMI), and insulin resistance (HOMA-IR). Depression severity was assessed by HAM-D-21. Results: In female (n = 14) (but not in male) patients HAM-D-21 scores correlated with plasma levels of AA (but not other Kyn metabolites) (rho = −0.644, P = .009) and leptin (Spearman’s rho = −0.775, P = .001). Inclusion of AA into regression analysis improved leptin prediction of HAM-D from 48.5% to 65.9%. Actual HAM-D scores highly correlated with that calculated by formula: HAM-D = 34.8518−(0.5660 × leptin [ng/ml] + 0.4159 × AA [nmol/l]) (Rho = 0.84, P = .00015). In male (n = 15) (but not in female) patients leptin correlated with BMI, waist circumference/hip ratio, CRP, and HOMA-IR. Conclusions: Present findings of gender specific AA/Leptin correlations with HAM-D are important considering that AA and leptin are transported from plasma into brain, and that AA formation is catalyzed by kynureninase—the only TKP gene associated with depression according to genome-wide analysis. High correlation between predicted and actual HAM-D warrants further evaluation of plasma AA and leptin as an objective laboratory test for the assessment of depression severity in female MDD patients

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