scholarly journals Ketamine: translating mechanistic discoveries into the next generation of glutamate modulators for mood disorders

2017 ◽  
Vol 22 (3) ◽  
pp. 324-327 ◽  
Author(s):  
C A Zarate ◽  
R Machado-Vieira
Keyword(s):  
Mood Disorders ◽  
Next Generation ◽  
Glutamate Modulators

scholarly journals Glutamate modulators as novel interventions for mood disorders

2005 ◽  
Vol 27 (3) ◽  
pp. 243-248 ◽  
Author(s):  
Sanjay J Mathew ◽  
Kathryn Keegan ◽  
Lisa Smith
Keyword(s):  
Mood Disorders ◽  
Ampa Receptor ◽  
Clinical Investigation ◽  
Nmda Receptor Antagonist ◽  
Open Label ◽  
Vesicular Release ◽  
Glutamate Modulators ◽  
Neuroprotective Function ◽  
Neurotrophic Signaling ◽  
Ampa Receptor Potentiators

Recent evidence suggests that critical molecules in neurotrophic signaling cascades are long-term targets for currently available monoaminergic antidepressants. As chronic and severe mood disorders are characterized by impairments in neuronal resilience, pharmacological strategies that subserve a neuroprotective function might alter disorder pathophysiology and modify disease progression. Several promising approaches involve modulation of the glutamate neurotransmitter system, via post-synaptic receptor blockade or potentiation and presynaptic vesicular release inhibition. A focused review of the extant scientific literature was conducted, with a discussion of 3 compounds or classes of drugs currently undergoing clinical investigation: ketamine, riluzole, and AMPA receptor potentiators. Recent investigations in mood disordered patients suggest that the NMDA receptor antagonist ketamine might demonstrate rapid antidepressant properties. Riluzole has been shown to reverse glutamate-mediated impairments in neuronal plasticity and to stimulate the synthesis of brain derived neurotrophic factor. Open-label trials in treatment-resistant depression have yielded promising results. Likewise, AMPA receptor potentiators favorably impact neurotrophic factors as well as enhance cognition. CONCLUSIONS: Pharmacological approaches that modulate components of the glutamate system offer novel targets for severe, recurrent mood disorders. Controlled studies are necessary.

1477: Durability of Next Generation Flexible Ureteroscopes: Randomized Prospective Study

2004 ◽  
Vol 171 (4S) ◽  
pp. 389-389
Author(s):  
Manoj Monga ◽  
Ramakrishna Venkatesh ◽  
Sara Best ◽  
Caroline D. Ames ◽  
Courtney Lee ◽  
...  
Keyword(s):  
Prospective Study ◽  
Next Generation ◽  
Flexible Ureteroscopes
Sign in / Sign up

Export Citation Format

Share Document