scholarly journals Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway

2016 ◽  
Vol 22 (1) ◽  
pp. 13-23 ◽  
Author(s):  
V R Varma ◽  
◽  
S Varma ◽  
Y An ◽  
T J Hohman ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Injury

Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer’s Disease

2019 ◽  
Vol 19 (1) ◽  
pp. 43-50 ◽  
Author(s):  
Timo Grimmer ◽  
Oliver Goldhardt ◽  
Igor Yakushev ◽  
Marion Ortner ◽  
Christian Sorg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fdg Pet ◽  
Amyloid Β ◽  
Neuronal Injury ◽  
Pittsburgh Compound B ◽  
Positron Emission ◽  
Amyloid Load ◽  
Alzheimer’S Pathology

Background: Neprilysin (NEP) cleaves amyloid-β 1–42 (Aβ42) in the brain. Hence, we aimed to elucidate the effect of NEP on Aβ42 in cerebrospinal fluid (CSF) and on in vivo brain amyloid load using amyloid positron emission tomography (PET) with [11C]PiB (Pittsburgh compound B). In addition, associations with the biomarkers for neuronal injury, CSF-tau and FDG-PET, were investigated. Methods: Associations were calculated using global and voxel-based (SPM8) linear regression analyses in the same cohort of 23 highly characterized Alzheimer’s disease patients. Results: CSF-NEP was significantly inversely associated with CSF-Aβ42 and positively with the extent of neuronal injury as measured by CSF-tau and FDG-PET. Conclusions: Our results on CSF-NEP are compatible with the assumption that local degradation, amongst other mechanisms of amyloid clearance, plays a role in the development of Alzheimer’s pathology. In addition, CSF-NEP is associated with the extent and the rate of neurodegeneration.

Cerebrospinal Fluid Levels of a 20–22 kDa NH2 Fragment of Human Tau Provide a Novel Neuronal Injury Biomarker in Alzheimer's Disease and Other Dementias

2014 ◽  
Vol 42 (1) ◽  
pp. 211-226 ◽  
Author(s):  
Giuseppina Amadoro ◽  
Veronica Corsetti ◽  
Giulia Maria Sancesario ◽  
Adele Lubrano ◽  
Gaia Melchiorri ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Neuronal Injury ◽  
Cerebrospinal Fluid Levels ◽  
Fluid Levels

[P1-416]: CSF TOTAL TAU AS A BIOMARKER FOR NEURONAL INJURY IN ALZHEIMER's DISEASE: ALIGNING RATES OF CSF CHANGE WITH RATES OF HIPPOCAMPAL AND CORTICAL GRAY MATTER ATROPHY

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P436-P436
Author(s):  
James D. Doecke ◽  
Qiao-Xin Li ◽  
Pierrick Bourgeat ◽  
Christopher Fowler ◽  
Steven Collins ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gray Matter ◽  
Neuronal Injury ◽  
Total Tau ◽  
Gray Matter Atrophy ◽  
Cortical Gray Matter

scholarly journals Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease

2018 ◽  
Vol 10 (1) ◽  
pp. 669-677
Author(s):  
Nelly Joseph‐Mathurin ◽  
Yi Su ◽  
Tyler M. Blazey ◽  
Mateusz Jasielec ◽  
Andrei Vlassenko ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Injury

scholarly journals Neuronal injury biomarkers for assessment of the individual cognitive reserve in clinically suspected Alzheimer's disease

2019 ◽  
Vol 24 ◽  
pp. 101949 ◽  
Author(s):  
Leonie Beyer ◽  
Jonas Schnabel ◽  
Philipp Kazmierczak ◽  
Michael Ewers ◽  
Sonja Schönecker ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Reserve ◽  
Neuronal Injury ◽  
The Individual
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