Inducible ablation of dopamine D2 receptors in adult mice impairs locomotion, motor skill learning and leads to severe parkinsonism

2016 ◽  
Vol 22 (4) ◽  
pp. 595-604 ◽  
Author(s):  
E P Bello ◽  
R Casas-Cordero ◽  
G L Galiñanes ◽  
E Casey ◽  
M A Belluscio ◽  
...  
Keyword(s):  
Motor Skill ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Skill Learning ◽  
Motor Skill Learning ◽  
Dopamine D2 ◽  
Adult Mice

scholarly journals Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain

2019 ◽  
Author(s):  
Hui-quan Li ◽  
Nicholas C. Spitzer
Keyword(s):  
Motor Skills ◽  
Motor Skill ◽  
Viral Vectors ◽  
Wheel Running ◽  
Pedunculopontine Nucleus ◽  
Skill Learning ◽  
Motor Skill Learning ◽  
Adult Mice ◽  
Normal Individuals ◽  
Skills Use

AbstractPhysical exercise promotes motor skill learning in normal individuals and those with neurological disorders but its mechanism of action is unclear. We found that one week of voluntary wheel running enhances the acquisition of motor skills in adult mice. One week of running also induces switching from ACh to GABA expression in neurons in the caudal pedunculopontine nucleus (cPPN). The switching neurons make projections to the substantia nigra (SN), ventral tegmental area (VTA) and ventrolateral-ventromedial nuclei of the thalamus (VL-VM), which regulate acquisition of motor skills. Use of viral vectors to override transmitter switching blocks the beneficial effect of running on motor skill learning. We suggest that neurotransmitter switching provides the basis by which sustained running benefits motor skill learning, presenting a new target for clinical treatment of movement disorders.

The Effect of Aimed Movements in Sequenced Motor Skill Learning Motor Skill Acquisition Using Aiming and the SRTT

2008 ◽  
Author(s):  
Michelle V. Thompson ◽  
Janet L. Utschig ◽  
Mikaela K. Vaughan ◽  
Marc V. Richard ◽  
Benjamin A. Clegg
Keyword(s):  
Skill Acquisition ◽  
Motor Skill ◽  
Skill Learning ◽  
Motor Skill Learning ◽  
Motor Skill Acquisition

scholarly journals 371 STRIATAL DOPAMINE D2 RECEPTORS ATTENUATE NEUROPATHIC HYPERSENSITIVITY IN THE RAT

2007 ◽  
Vol 11 (S1) ◽  
pp. S165-S165
Author(s):  
O.B. Ansah ◽  
H. Leite-Almeida ◽  
H. Wei ◽  
A. Pertovaara
Keyword(s):  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Striatal Dopamine ◽  
Dopamine D2
Sign in / Sign up

Export Citation Format

Share Document