scholarly journals Ovarian Steroids Decrease DNA Fragmentation in the Serotonin Neurons of Non-Injured Rhesus Macaques

2009 ◽  
Vol 15 (6) ◽  
pp. 657-668 ◽  
Author(s):  
F B Lima ◽  
C L Bethea
Keyword(s):  
Dna Fragmentation ◽  
Rhesus Macaques ◽  
Ovarian Steroids ◽  
Serotonin Neurons

scholarly journals Estrogen and Serotonin: Complexity of Interactions and Implications for Epileptic Seizures and Epileptogenesis

2019 ◽  
Vol 17 (3) ◽  
pp. 214-231 ◽  
Author(s):  
Faheem Hyder Pottoo ◽  
Md. Noushad Javed ◽  
Md. Abul Barkat ◽  
Md. Sabir Alam ◽  
Javaid Ashraf Nowshehri ◽  
...  
Keyword(s):  
Neuronal Excitability ◽  
Epileptiform Activity ◽  
Epileptic Seizures ◽  
Seizure Threshold ◽  
Ovarian Steroids ◽  
Generalized Seizures ◽  
Organizational Activity ◽  
Serotonin Neurons ◽  
Anti Oxidant ◽  
Estrogen Administration

A burgeoning literature documents the confluence of ovarian steroids and central serotonergic systems in the injunction of epileptic seizures and epileptogenesis. Estrogen administration in animals reduces neuronal death from seizures by up-regulation of the prosurvival molecule i.e. Bcl-2, anti-oxidant potential and protection of NPY interneurons. Serotonin modulates epileptiform activity in either direction i.e administration of 5-HT agonists or reuptake inhibitors leads to the activation of 5-HT3 and 5-HT1A receptors tending to impede focal and generalized seizures, while depletion of brain 5-HT along with the destruction of serotonergic terminals leads to expanded neuronal excitability hence abatement of seizure threshold in experimental animal models. Serotonergic neurotransmission is influenced by the organizational activity of steroid hormones in the growing brain and the actuation effects of steroids which come in adulthood. It is further established that ovarian steroids bring induction of dendritic spine proliferation on serotonin neurons thus thawing a profound effect on serotonergic transmission. This review features 5-HT1A and 5-HT3 receptors as potential targets for ameliorating seizure-induced neurodegeneration and recurrent hypersynchronous neuronal activity. Indeed 5-HT3 receptors mediate cross-talk between estrogenic and serotonergic pathways, and could be well exploited for combinatorial drug therapy against epileptogenesis.

Regulation of serotonin re-uptake transporter mRNA expression by ovarian steroids in rhesus macaques

1998 ◽  
Vol 53 (1-2) ◽  
pp. 120-129 ◽  
Author(s):  
Melanie Pecins-Thompson ◽  
Nancy A. Brown ◽  
Cynthia L Bethea
Keyword(s):  
Mrna Expression ◽  
Rhesus Macaques ◽  
Ovarian Steroids

DNA-fragmentation and expression of apoptosis-related proteins in experimentally denervated and reinnervated rat facial muscle

1997 ◽  
Vol 23 (3) ◽  
pp. 141-149 ◽  
Author(s):  
D. S. Tews ◽  
H. H. Goebel ◽  
I. Schneider ◽  
A. Gunkel ◽  
E. Stennert ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Facial Muscle ◽  
Related Proteins
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