scholarly journals Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts

2008 ◽  
Vol 15 (6) ◽  
pp. 589-601 ◽  
Author(s):  
P Muglia ◽  
F Tozzi ◽  
N W Galwey ◽  
C Francks ◽  
R Upmanyu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Case Control ◽  
Genome Wide Association ◽  
Major Depressive ◽  
Genome Wide ◽  
Recurrent Major Depressive Disorder

scholarly journals Genome-wide association study of recurrent early-onset major depressive disorder

2010 ◽  
Vol 16 (2) ◽  
pp. 193-201 ◽  
Author(s):  
J Shi ◽  
J B Potash ◽  
J A Knowles ◽  
M M Weissman ◽  
W Coryell ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Association Study ◽  
Early Onset ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Major Depressive ◽  
Genome Wide

scholarly journals Genome-wide association study of circadian rhythmicity in 71 500 UK Biobank participants and polygenic association with mood instability

2018 ◽  
Author(s):  
Amy Ferguson ◽  
Laura M. Lyall ◽  
Joey Ward ◽  
Rona J. Strawbridge ◽  
Breda Cullen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Circadian Rhythmicity ◽  
Genome Wide Association ◽  
Uk Biobank ◽  
Major Depressive ◽  
Mood Instability ◽  
Genome Wide

AbstractBackgroundCircadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder.MethodsWe conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of circadian rhythmicity derived from the accelerometer data of 71 500 UK Biobank participants. Polygenic risk scores (PRS) for low RA were used to investigate potential associations with psychiatric phenotypes.OutcomesTwo independent genetic loci were associated with low RA, within genomic regions for Neurofascin (NFASC) and Solute Carrier Family 25 Member 17 (SLC25A17). A secondary GWAS of RA as a continuous measure identified a locus within Meis Homeobox 1 (MEIS1). There were no significant genetic correlations between low RA and any of the psychiatric phenotypes assessed. However, PRS for low RA was significantly associated with mood instability across multiple PRS thresholds (at PRS threshold 0·05: OR=1·02, 95% CI=1·01-1·02, p=9·6×10−5), and with major depressive disorder (at PRS threshold 0·1: OR=1·03, 95% CI=1·01-1·05, p=0·025) and neuroticism (at PRS threshold 0·5: Beta=0·02, 95% CI=0·007-0·04, p=0·021).InterpretationOverall, our findings contribute new knowledge on the complex genetic architecture of circadian rhythmicity and suggest a putative biological link between disrupted circadian function and mood disorder phenotypes, particularly mood instability, but also major depressive disorder and neuroticism.

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