scholarly journals Melanoma Growth Stimulatory Activity in Primary Malignant Melanoma: Prognostic Significance

2002 ◽  
Vol 15 (5) ◽  
pp. 532-537 ◽  
Author(s):  
Benton R Middleman ◽  
Michael Friedman ◽  
David H Lawson ◽  
Patricia B DeRose ◽  
Cynthia Cohen
Keyword(s):  
Malignant Melanoma ◽  
Prognostic Significance ◽  
Primary Malignant Melanoma ◽  
Stimulatory Activity ◽  
Melanoma Growth

Prognostic significance of nestin in primary malignant melanoma of the oral cavity

2016 ◽  
Vol 26 (5) ◽  
pp. 457-463 ◽  
Author(s):  
Su Kyung Kuk ◽  
Chong Hyun Won ◽  
Woo Jin Lee ◽  
Wui Jung Shin ◽  
Hye Jung Yoon ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Oral Cavity ◽  
Prognostic Significance ◽  
Primary Malignant Melanoma

Preparation of a monoclonal antibody to a melanoma growth-stimulatory activity released into serum-free culture medium by Hs0294 malignant melanoma cells

1987 ◽  
Vol 34 (3) ◽  
pp. 169-185 ◽  
Author(s):  
David H. Lawson ◽  
H. Greg Thomas ◽  
Robert G. B. Roy ◽  
David S. Gordon ◽  
Rajender K. Chawla ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Malignant Melanoma ◽  
Culture Medium ◽  
Melanoma Cells ◽  
Serum Free ◽  
Stimulatory Activity ◽  
Melanoma Growth

Neurotransmitter systems of female mouse brain during growth of malignant melanoma modeled on the background of chronic pain

2018 ◽  
pp. 49-55
Author(s):  
О.И. Кит ◽  
И.М. Котиева ◽  
Е.М. Франциянц ◽  
И.В. Каплиева ◽  
Л.К. Трепитаки ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Cerebral Cortex ◽  
Malignant Melanoma ◽  
Sciatic Nerve ◽  
Female Mouse ◽  
Combined Effects ◽  
Malignant Growth ◽  
Course Of Disease ◽  
The Brain ◽  
Melanoma Growth

Известно, что биогенные амины (БА) участвуют в злокачественном росте, их уровень изменяется в ЦНС при болевом воздействии, однако исследований о сочетанном влиянии хронической боли (ХБ) и онкопатологии на динамику БА в головном мозге не проводилось. Цель: изучить особенности баланса БА в коре головного мозга в динамике роста меланомы, воспроизведенной на фоне ХБ. Материалы и методы. Работа выполнена на 64 мышах-самках, весом 21-22 г. Животным основной группы меланому В16/F10 перевивали под кожу спины через 2 недели после перевязки седалищных нервов. Группой сравнения служили мыши с меланомой без боли. Уровни БА: адреналина, норадреналина, дофамина (ДА), серотонина (5-НТ), гистамина, а также 5-ОИУК определяли методом иммуноферментного анализа. Результаты. У мышей с ХБ уменьшается содержание большинства БА, однако уровень ДА не изменяется. Метаболизм 5-НТ происходит с участием МАО. Развитие меланомы сопровождается увеличением содержания ДА и 5-НТ, тогда как МАО - ингибируется. Направленность сдвигов БА при развитии меланомы на фоне ХБ оказалась практически такой же, как и без неё. В то же время ХБ ограничивает накопление 5-НТ в коре мозга при меланоме, что сопровождается более агрессивным её течением. Выводы. ХБ ограничивает включение стресс-лимитирующих механизмов в головном мозге при развитии меланомы у мышей, что приводит к более агрессивному течению злокачественного процесса. Biogenic amines (BA) are known to be involved in malignant growth, and their CNS levels change in pain; however, there are no studies of combined effects of chronic pain (CP) and cancer on BA dynamics in the brain. Aim: To study features of BA balance in the cerebral cortex during melanoma growth associated with CP. Material and methods. The study included 64 female mice weighing 21-22 g. In the main groups, B16/F10 melanoma was transplanted under the skin of the back two weeks following sciatic nerve ligation. Mice with melanoma without pain were used as the control. Concentrations of BA: adrenaline, noradrenaline, dopamine (DA), serotonin (5-HT), histamine and 5-HIAA were measured with ELISA. Results. Concentrations of BAs decreased in mice with CP although DA levels did not change. 5-HT metabolism involved MAO. The development of melanoma was accompanied by increases in DA and 5-HT whereas MAO was inhibited. The direction of BA changes during the development of melanoma was the same with and without CP. At the same time, CP with melanoma limited accumulation of 5-HT in the cerebral cortex, which resulted in even more aggressive course of cancer. Conclusion. CP restricted the activation of cerebral stress-limiting mechanisms during the development of melanoma in mice, which resulted in a more aggressive course of disease.

scholarly journals Primary malignant melanoma of the lacrimal sac

2012 ◽  
Vol 2012 (aug09 1) ◽  
pp. bcr2012006349-bcr2012006349 ◽  
Author(s):  
Y.-J. Li ◽  
S.-J. Zhu ◽  
H. Yan ◽  
J. Han ◽  
D. Wang ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Primary Malignant Melanoma ◽  
Lacrimal Sac

scholarly journals Primary Malignant Melanoma of the Vagina without Metastasis: A Rare Case and Review of Literature

2020 ◽  
Author(s):  
Wilson Bizimana ◽  
Gloria Akimana ◽  
Arthur Semedo Insumbo ◽  
Hounayda Jerguigue ◽  
Rachida Latib ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Patient Survival ◽  
Rare Condition ◽  
Primary Malignant Melanoma ◽  
Imaging Features ◽  
Review Of Literature ◽  
Pelvic Magnetic Resonance Imaging ◽  
Improve Patient Survival ◽  
Appropriate Treatment ◽  
Improve Patient

AbstractMalignant melanoma of vagina is a rare condition. Its histogenesis has been debated and the positive diagnosis is based on immunohistochemistry. Pelvic magnetic resonance imaging remains the gold standard for assessing locoregional extension status and post-treatment surveillance of melanoma of vagina. The observation concerned a 53-year-old woman with no specific history who presented a primary malignant melanoma of vagina without secondary locations. To date, the case is the second one reported in the literature. Early diagnosis of the malignant melanoma of vagina may improve patient survival because late diagnoses are punctuated by poor prognosis. We have presented epidemiological with etiopathogenic characteristics and described all imaging features to stage the tumor and to conduct the appropriate treatment.

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