scholarly journals Clinical, Histopathological, and Immunogenetic Analysis of Ocular Adnexal Lymphoproliferative Disorders: Characterization of MALT Lymphoma and Reactive Lymphoid Hyperplasia

2001 ◽  
Vol 14 (7) ◽  
pp. 641-649 ◽  
Author(s):  
Tomohiko Mannami ◽  
Tadashi Yoshino ◽  
Koichi Oshima ◽  
Sumie Takase ◽  
Eisaku Kondo ◽  
...  
Keyword(s):  
Malt Lymphoma ◽  
Lymphoid Hyperplasia ◽  
Lymphoproliferative Disorders ◽  
Reactive Lymphoid Hyperplasia ◽  
Immunogenetic Analysis

scholarly journals Clinical Aspects of IgG4-Related Orbital Inflammation in a Case Series of Ocular Adnexal Lymphoproliferative Disorders

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Masayuki Takahira ◽  
Yoshiaki Ozawa ◽  
Mitsuhiro Kawano ◽  
Yoh Zen ◽  
Shoko Hamaoka ◽  
...  
Keyword(s):  
Malt Lymphoma ◽  
Case Series ◽  
B Cell Lymphoma ◽  
Lymphoid Hyperplasia ◽  
Lymphoproliferative Disorders ◽  
Clinical Aspects ◽  
Lacrimal Glands ◽  
Malignant Lymphomas ◽  
Orbital Inflammation ◽  
Adnexal Tumors

The most frequent ocular adnexal tumors and simulating lesions are lymphoproliferative disorders (LPDs), including malignant lymphomas and orbital inflammation with lymphoid hyperplasia or infiltration. IgG4-related orbital inflammation (IgG4-ROI) often involves lacrimal glands and other orbital tissues and is an important differential diagnosis. The present study evaluated clinical aspects of IgG4-ROI in a case series of orbital LPD. Sixty-two consecutive cases of orbital LPD, pathologically diagnosed from November, 2004, through March, 2011, were investigated. Histological types were 22 cases with MALT lymphoma, 11 cases with diffuse large B-cell lymphoma (DLBCL), 3 cases with other malignant lymphomas, 16 cases with IgG4-ROI, and 10 cases with non-IgG4-ROI. Ages of the IgG4-ROI group (56±10?yrs) were significantly lower than the MALT lymphoma (71±12?yrs) and DLBCL (75±14?yrs) groups. Orbital lesions other than lacrimal glands were present in six cases including extraocular muscle swelling, mass lesions surrounding the optic nerve, and supraorbital and infraorbital nerves enlargements. Although none of the malignant lymphomas were related to IgG4, previous evidence suggested that malignant lymphomas can arise from IgG4-ROI. Based on this study (26%) and another report (33%), it is likely that nearly a quarter of orbital LPD are IgG4-ROI.

scholarly journals Comprehensive Gene Analysis of IgG4-Related Ophthalmic Disease Using RNA Sequencing

2020 ◽  
Vol 9 (11) ◽  
pp. 3458
Author(s):  
Masaki Asakage ◽  
Yoshihiko Usui ◽  
Naoya Nezu ◽  
Hiroyuki Shimizu ◽  
Kinya Tsubota ◽  
...  
Keyword(s):  
Real Time ◽  
Rna Sequencing ◽  
Malt Lymphoma ◽  
Lymphoid Hyperplasia ◽  
Reactive Lymphoid Hyperplasia ◽  
Rna Seq ◽  
Immunoglobulin G4 ◽  
Tissue Samples ◽  
Biopsy Specimens ◽  
Ophthalmic Disease

High-throughput RNA sequencing (RNA-seq) uses massive parallel sequencing technology, allowing the unbiased analysis of genome-wide transcription levels and tumor mutation status. Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) is a fibroinflammatory disease characterized by the enlargement of the ocular adnexal tissues. We analyzed RNA expression levels via RNA-seq in the biopsy specimens of three patients diagnosed with IgG4-ROD. Mucosa-associated lymphoid tissue (MALT) lymphoma, reactive lymphoid hyperplasia (RLH), normal lacrimal gland tissue, and adjacent adipose tissue were used as the controls (n = 3 each). RNA-seq was performed using the NextSeq 500 system, and genes with |fold change| ≥ 2 and p < 0.05 relative to the controls were defined as differentially expressed genes (DEGs) in IgG4-ROD. To validate the results of RNA-seq, real-time polymerase chain reaction (PCR) was performed in 30 IgG4-ROD and 30 orbital MALT lymphoma tissue samples. RNA-seq identified 35 up-regulated genes, including matrix metallopeptidase 12 (MMP12) and secreted phosphoprotein 1 (SPP1), in IgG4-ROD tissues when compared to all the controls. Many pathways related to the immune system were included when compared to all the controls. Expressions of MMP12 and SPP1 in IgG4-ROD tissues were confirmed by real-time PCR and immunohistochemistry. In conclusion, we identified novel DEGs, including those associated with extracellular matrix degradation, fibrosis, and inflammation, in IgG4-ROD biopsy specimens. These data provide new insights into molecular pathogenetic mechanisms and may contribute to the development of new biomarkers for diagnosis and molecular targeted drugs.

Characterization of Smoking-Induced Nasopharyngeal Lymphoid Hyperplasia

1997 ◽  
Vol 107 (12) ◽  
pp. 1635-1642 ◽  
Author(s):  
Yehuda Finkelstein ◽  
Zvi Malik ◽  
Juri Kopolovic ◽  
Jöelle Bernheim ◽  
Meir Djaldetti ◽  
...  
Keyword(s):  
Lymphoid Hyperplasia

Reactive lymphoid hyperplasia of the liver. A case report

2019 ◽  
Vol 52 (4) ◽  
pp. 246-249
Author(s):  
María Luisa Suárez-Solís ◽  
Sofía de la Serna ◽  
José Manuel Espejo Domínguez ◽  
Luis Ortega Medina
Keyword(s):  
Case Report ◽  
Lymphoid Hyperplasia ◽  
Reactive Lymphoid Hyperplasia

Characterization of the tumor microenvironment in primary cutaneous CD30-positive lymphoproliferative disorders: a predominance of CD163-positive M2 macrophages

2016 ◽  
Vol 43 (7) ◽  
pp. 579-588 ◽  
Author(s):  
Aieska De Souza ◽  
Marianne Tinguely ◽  
Daniel R. Burghart ◽  
Arbeneshe Berisha ◽  
Kirsten D. Mertz ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Lymphoproliferative Disorders ◽  
M2 Macrophages

scholarly journals Reactive Lymphoid Hyperplasia of the Liver in a Patient with Ascending Colon Cancer: Report of a Case

2007 ◽  
Vol 40 (3) ◽  
pp. 331-336 ◽  
Author(s):  
Hiroki Takahashi ◽  
Yoichi Matsuo ◽  
Minoru Yamamoto ◽  
Hirozumi Sawai ◽  
Mikinori Satoh ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymphoid Hyperplasia ◽  
Reactive Lymphoid Hyperplasia ◽  
Ascending Colon ◽  
Ascending Colon Cancer
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