scholarly journals Prostaglandin D Synthase (β-Trace) in Meningeal Hemangiopericytoma

2001 ◽  
Vol 14 (3) ◽  
pp. 197-201 ◽  
Author(s):  
Masatou Kawashima ◽  
Satoshi O Suzuki ◽  
Tetsumori Yamashima ◽  
Masashi Fukui ◽  
Toru Iwaki
Keyword(s):  
Prostaglandin D Synthase ◽  
Meningeal Hemangiopericytoma

Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase

2021 ◽  
Vol 569 ◽  
pp. 66-71
Author(s):  
Shigeru Shimamoto ◽  
Yusuke Nakagawa ◽  
Yuji Hidaka ◽  
Takahiro Maruno ◽  
Yuji Kobayashi ◽  
...  
Keyword(s):  
Release Mechanism ◽  
Product Release ◽  
Prostaglandin D Synthase

scholarly journals Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Bo Diao ◽  
Chenhui Wang ◽  
Rongshuai Wang ◽  
Zeqing Feng ◽  
Ji Zhang ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Kidney Injury ◽  
Human Kidney ◽  
The Elderly ◽  
Tubular Damage ◽  
Clinical Parameters ◽  
Double Staining ◽  
Protein Deposits ◽  
Prostaglandin D Synthase

AbstractIt is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect human kidney, thus leading to acute kidney injury (AKI). Here, we perform a retrospective analysis of clinical parameters from 85 patients with laboratory-confirmed coronavirus disease 2019 (COVID-19); moreover, kidney histopathology from six additional COVID-19 patients with post-mortem examinations was performed. We find that 27% (23/85) of patients exhibited AKI. The elderly patients and cases with comorbidities (hypertension and heart failure) are more prone to develop AKI. Haematoxylin & eosin staining shows that the kidneys from COVID-19 autopsies have moderate to severe tubular damage. In situ hybridization assays illustrate that viral RNA accumulates in tubules. Immunohistochemistry shows nucleocapsid and spike protein deposits in the tubules, and immunofluorescence double staining shows that both antigens are restricted to the angiotensin converting enzyme-II-positive tubules. SARS-CoV-2 infection triggers the expression of hypoxic damage-associated molecules, including DP2 and prostaglandin D synthase in infected tubules. Moreover, it enhances CD68+ macrophages infiltration into the tubulointerstitium, and complement C5b-9 deposition on tubules is also observed. These results suggest that SARS-CoV-2 directly infects human kidney to mediate tubular pathogenesis and AKI.

Pharmacokinetics of recombinant human lipocalin-type prostaglandin D synthase/β-trace in canine

2008 ◽  
Vol 61 (3) ◽  
pp. 289-293 ◽  
Author(s):  
Weidong Li ◽  
Mitsuhito Mase ◽  
Takashi Inui ◽  
Minoru Shimoda ◽  
Kenichi Isomura ◽  
...  
Keyword(s):  
Prostaglandin D Synthase

scholarly journals Prostaglandin D Synthase (β-trace) in Healthy Human Sleep

SLEEP ◽  
2004 ◽  
Vol 27 (5) ◽  
pp. 867-874 ◽  
Author(s):  
Wolfgang Jordan ◽  
Hayrettin Tumani ◽  
Stefan Cohrs ◽  
Sebastian Eggert ◽  
Andrea Rodenbeck ◽  
...  
Keyword(s):  
Healthy Human ◽  
Human Sleep ◽  
Prostaglandin D Synthase

Molecular structure of a prostaglandin D synthase requiring glutathione from the brown planthopper, Nilaparvata lugens

2017 ◽  
Vol 492 (2) ◽  
pp. 166-171 ◽  
Author(s):  
Kohji Yamamoto ◽  
Akifumi Higashiura ◽  
Mamoru Suzuki ◽  
Kosuke Aritake ◽  
Yoshihiro Urade ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Brown Planthopper ◽  
Nilaparvata Lugens ◽  
Prostaglandin D Synthase

scholarly journals Expression of lipocalin-type prostaglandin D synthase in preeclampsia patients: a novel marker for preeclampsia

2014 ◽  
Vol 2 (2) ◽  
pp. 72-77 ◽  
Author(s):  
Kazunori Kinoshita ◽  
Jun Takeda ◽  
Kikumi Matsuoka ◽  
Satoru Takeda ◽  
Yutaka Eguchi ◽  
...  
Keyword(s):  
Prostaglandin D Synthase
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