scholarly journals Human Small Cell Lung Carcinoma and Carcinoid Tumor Regulate Dendritic Cell Maturation and Function

2001 ◽  
Vol 14 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Nora S Katsenelson ◽  
Galina V Shurin ◽  
Svetlana N Bykovskaia ◽  
Jeffrey Shogan ◽  
Michael R Shurin
Keyword(s):  
Dendritic Cell ◽  
Carcinoid Tumor ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Dendritic Cell Maturation ◽  
Small Cell ◽  
Cell Maturation ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
And Function

Frequent loss of Fas expression and function in human lung tumours with overexpression of FasL in small cell lung carcinoma

2003 ◽  
Vol 201 (2) ◽  
pp. 268-277 ◽  
Author(s):  
Isabelle Viard-Leveugle ◽  
Sylvie Veyrenc ◽  
Lars E French ◽  
Christian Brambilla ◽  
Elisabeth Brambilla
Keyword(s):  
Lung Carcinoma ◽  
Human Lung ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Lung Tumours ◽  
And Function

Laminin receptor expression and function in small-cell lung carcinoma

1994 ◽  
Vol 57 (S8) ◽  
pp. 116-120 ◽  
Author(s):  
Rita Pellegrini ◽  
Stefania Martignone ◽  
Sylvie Ménard ◽  
Maria Ines Colnaghi
Keyword(s):  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Receptor Expression ◽  
Laminin Receptor ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
And Function

Clinical Features And Outcomes Of Patients With Small Cell Lung Carcinoma; Retrospective Analysis

2015 ◽  
Vol 3 (2) ◽  
pp. 47 ◽  
Author(s):  
Duygu Unalmış ◽  
Zehra Yasar ◽  
Melih Buyuksirin ◽  
Gulru Polat ◽  
Fatma Demirci Ucsular ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Clinical Features ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma

Radiosurgery for patients with recurrent small cell lung carcinoma metastatic to the brain: outcomes and prognostic factors

2005 ◽  
Vol 102 (Special_Supplement) ◽  
pp. 247-254 ◽  
Author(s):  
Jason Sheehan ◽  
Douglas Kondziolka ◽  
John Flickinger ◽  
L. Dade Lunsford
Keyword(s):  
Lung Cancer ◽  
Brain Metastases ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Content Type ◽  
The Brain ◽  
Fine Print

Object. Lung carcinoma is the leading cause of death from cancer. More than 50% of those with small cell lung cancer develop a brain metastasis. Corticosteroid agents, radiotherapy, and resection have been the mainstays of treatment. Nonetheless, median survival for patients with small cell lung carcinoma metastasis is approximately 4 to 5 months after cranial irradiation. In this study the authors examine the efficacy of gamma knife surgery for treating recurrent small cell lung carcinoma metastases to the brain following tumor growth in patients who have previously undergone radiation therapy, and they evaluate factors affecting survival. Methods. A retrospective review of 27 patients (47 recurrent small cell lung cancer brain metastases) undergoing radiosurgery was performed. Clinical and radiographic data obtained during a 14-year treatment period were collected. Multivariate analysis was utilized to determine significant prognostic factors influencing survival. The overall median survival was 18 months after the diagnosis of brain metastases. In multivariate analysis, factors significantly affecting survival included: 1) tumor volume (p = 0.0042); 2) preoperative Karnofsky Performance Scale score (p = 0.0035); and 3) time between initial lung cancer diagnosis and development of brain metastasis (p = 0.0127). Postradiosurgical imaging of the brain metastases revealed that 62% decreased, 19% remained stable, and 19% eventually increased in size. One patient later underwent a craniotomy and tumor resection for a tumor refractory to radiosurgery and radiation therapy. In three patients new brain metastases were demonstrating on follow-up imaging. Conclusions. Stereotactic radiosurgery for recurrent small cell lung carcinoma metastases provided effective local tumor control in the majority of patients. Early detection of brain metastases, aggressive treatment of systemic disease, and a therapeutic strategy including radiosurgery can extend survival.

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