HIV-Associated Multinucleated Giant Cells in Lymphoid Tissue of the Waldeyer's Ring: A Detailed Study

Introduction: Tenosynovial giant cell tumor (TSGCT) (synonym – pigmented villonodular synovitis) – is a rare benign proliferative lesion of the synovial sheath, localized in the joint capsule, bursa or tendon sheath and characterized by locally destructive growth. Depending on the prevalence within the joint elements, the presence of a capsule around the tumor, histophotographic features of cell structure and clinical behavior TSGCT can be divided to localized or diffuse type. The aim of the study was researching of histopathological properties of diffuse-type TSGCT, determine the parameters its morphological indicators and to find out the correlation between these morphological and clinical parameters. Materials and methods: The research material was used biopsy (resect) of pathological lesions from 50 patients who were diagnosed and histologically verified diffuse-type TSGCT. Microscopic examinations of the stained sections and their photo archiving were carried out with use of a Olympus-CX 41 light optical microscope. Group measurable parameters (mean values and Pearson tetrachoric index (association coefficient) were calculated in groups of comparison for morphological and clinical indices of TSGCT. The mean values were compared by Student’s test, P value of ≤0.1 was considered statistically significant. Results:Correlation analysis of indicators that accounted for the pairs of cases «clinic – morphology» revealed the relationships, that had the highest parameters of the association coefficient between such indicators: «presence of villous growths» - «severity of hemosiderosis» (if hypertrophied synovial villi available, with vascular injection and pronounced proliferation of synovial cells, there is also a significant accumulation of hemosiderin pigment); «presence of villous growths» - «type of predominant cellular proliferates» (if cells of TSGCT diffuse type consists of monotonous sheets of stromal cells, with uniform, oval to reniform nuclei, the proliferation of villi in synovial layer is non-distinctive); «presence of nodes» - «kind of stroma» (if nodes predominate, their histological structure is mainly represented by polymorphic clusters of synovitis cells in the form of cells, strands, chains, solid formations, among immature connective tissue with low hyalinosis); «cell size (area, cm²)» - «severity of haemosiderosis» and «cell size (area, cm²)» - «the number of multinucleated giant cells» (there is a pronounced deposition of pigment and accumulation of osteoclast-like multinucleated giant cells type, although usually their number is relatively small compared to the localized type of TSGCT). Conclusions: Morphological parameters, that we have identified, characterize pathological changes in the tissues of TSGCT; careful analysis of the frequency of their occurrence in the different comparison groups made it possible to establish intergroup differences and correlations between individual indicators, which were previously unknown or not obvious. Our study was determine to analyze of incidence rates and correlation relationships, revealed some previously unknown differences and dependencies that are important for understanding the pathogenesis, improvement of diagnosis and prognosis of diffuse-type TSGCT.

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Kaposiform Hemangioendothelioma: clinicopathological characteristics of 8 cases of a rare vascular tumor and review of literature

Diagnostic Pathology ◽

10.1186/s13000-021-01080-9 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Qurratulain Chundriger ◽

Muhammad Usman Tariq ◽

Jamshid Abdul-Ghafar ◽

Arsalan Ahmed ◽

Nasir Ud Din

Keyword(s):

Pediatric Population ◽

Adult Population ◽

Correct Diagnosis ◽

Kaposi Sarcoma ◽

Minor Component ◽

Vascular Tumor ◽

Giant Cells ◽

Clinicopathological Characteristics ◽

Multinucleated Giant Cells ◽

Kaposiform Hemangioendothelioma

Abstract Background Kaposiform Hemangioendothelioma (KHE) is a rare vascular tumor of intermediate malignant potential which shows locally aggressive growth but only rarely metastasizes. It is mostly considered to be a tumor of pediatric population but its occurrence in the adults is not uncommon as once considered. Histologically, KHE can mimic other soft tissue neoplasms of different behaviors (e.g. Kaposi Sarcoma, hemangioma) and establishing the correct diagnosis is important for appropriate treatment. Herein, we describe the clinicopathological features of 8 cases of KHE which will be helpful in making their diagnosis. Methods We reviewed pathology reports, microscopy glass slides and obtained follow up information about 8 cases of KHE which were diagnosed at our institution from January 2008 till June 2020. Immunohistochemical stain for HHV8 was also performed. Results Age ranged from 7 months to 25 years. Seven patients were less than 20 years of age and one patient was 25 years old. Equal gender distribution was observed. Extremities were the most common sites of involvement, followed by head and neck, pancreas and ischiorectal region. 2 cases were resection specimen and all others were incisional biopsies. The largest tumor size was 5.5 cm in one of the resections. The incisional/fragmented tissues were all less than 5 cm in aggregate. Most cases showed predominance of nodular growth and a minor component of spindle cell population along with lymphangiomatosis like vascular channels, with evidence of microthrombi in 2 cases. Few multinucleated giant cells were observed in 2 cases. None of the cases exhibited significant nuclear atypia or mitotic activity. One of the cases arising in dermis showed underlying bone involvement. HHV8 was negative in 7/7 cases. Conclusions KHE can also involve adult population and it should always be considered in the differential diagnoses of a vascular lesion. Presence of multinucleated giant cells is a rare finding. Knowledge about histological features and potential mimics is helpful in avoiding misdiagnosis.

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Osseointegration of Zirconia in the Presence of Multinucleated Giant Cells

Clinical Implant Dentistry and Related Research ◽

10.1111/cid.12375 ◽

2015 ◽

Vol 18 (4) ◽

pp. 686-698 ◽

Cited By ~ 21

Author(s):

Vivianne Chappuis ◽

Yeliz Cavusoglu ◽

Reinhard Gruber ◽

Ulrike Kuchler ◽

Daniel Buser ◽

...

Keyword(s):

Giant Cells ◽

Multinucleated Giant Cells

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Villonodular synovitis in the spinal canal

Journal of Neurosurgery ◽

10.3171/jns.1980.52.6.0846 ◽

1980 ◽

Vol 52 (6) ◽

pp. 846-848 ◽

Cited By ~ 34

Author(s):

George M. Kleinman ◽

T. Forcht Dagi ◽

Charles E. Poletti

Keyword(s):

Giant Cell Tumor ◽

Spinal Canal ◽

Giant Cells ◽

Cell Tumor ◽

Villonodular Synovitis ◽

Rare Occurrence ◽

Multinucleated Giant Cells ◽

Content Type ◽

Synovial Tissues ◽

Fine Print

✓ Villonodular synovitis is believed to be an inflammatory, proliferative reaction of synovial tissues. The case of a 65-year-old woman with a cervical epidural mass is presented in which histological examination showed that the lesion was villonodular synovitis, an extremely rare occurrence. Because of its cellularity and occasional multinucleated giant cells, villonodular synovitis may be confused with metastatic malignancies or giant-cell tumor of bone.

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Fibroadenoma and Phyllodes Tumors of Anogenital Mammary-like Glands: A Series of 13 Neoplasms in 12 Cases, Including Mammary-type Juvenile Fibroadenoma, Fibroadenoma With Lactation Changes, and Neurofibromatosis-associated Pseudoangiomatous Stromal Hyperplasia With Multinucleated Giant Cells

The American Journal of Surgical Pathology ◽

10.1097/pas.0b013e3181c6e5c5 ◽

2010 ◽

Vol 34 (1) ◽

pp. 95-103 ◽

Cited By ~ 41

Author(s):

Dmitry V. Kazakov ◽

Dominic V. Spagnolo ◽

Colin J. Stewart ◽

Jane Thompson ◽

Abbas Agaimy ◽

...

Keyword(s):

Giant Cells ◽

Multinucleated Giant Cells ◽

Phyllodes Tumors ◽

Pseudoangiomatous Stromal Hyperplasia

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Non-Invasive Detection of Multinucleated Giant Cells in the Conjunctiva of Patients with Sarcoidosis by In-Vivo Confocal Microscopy

Ocular Immunology and Inflammation ◽

10.1080/09273940600826471 ◽

2006 ◽

Vol 14 (4) ◽

pp. 203-206 ◽

Cited By ~ 4

Author(s):

Michael S. Wertheim ◽

William D. Mathers ◽

Lyndell Lim ◽

Angela S. Watkins ◽

Friederike Mackensen ◽

...

Keyword(s):

Confocal Microscopy ◽

Giant Cells ◽

In Vivo Confocal Microscopy ◽

Multinucleated Giant Cells ◽

Non Invasive

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