scholarly journals Epithelioid Leiomyosarcoma in a Non-Immunocompromised Infant: Additional Differential Diagnosis of Pediatric “Round Cell Tumors”

2000 ◽  
Vol 13 (10) ◽  
pp. 1156-1160 ◽  
Author(s):  
Keisuke Kato ◽  
Kokoro Arai ◽  
Yukichi Tanaka ◽  
Rieko Ijiri ◽  
Yoshikazu Kato ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Round Cell ◽  
Round Cell Tumors

scholarly journals EWSR1 Rearrangement and CD99 Expression as Diagnostic Biomarkers for Ewing/PNET Sarcomas in a Moroccan Population

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Sara Louati ◽  
Nadia Senhaji ◽  
Laila Chbani ◽  
Sanae Bennis
Keyword(s):  
Differential Diagnosis ◽  
Sensitivity And Specificity ◽  
Ewing Sarcoma ◽  
Primitive Neuroectodermal Tumor ◽  
Neuroectodermal Tumor ◽  
Fish Analysis ◽  
Round Cell ◽  
Diagnostic Biomarkers ◽  
Moroccan Population ◽  
Round Cell Tumors

Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) are a group of round cell tumors. Malignant round cell tumors form a large and diverse group that includes rhabdomyosarcoma, synovial sarcoma, non-Hodgkin’s lymphoma, neuroblastoma, hepatoblastoma, Wilm’s tumor, desmoplastic small round cell tumor, and other morphologically similar entities. Differential diagnosis of Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) is difficult. In addition to morphology and immunohistochemistry (IHC), differential diagnosis of these tumors is based on molecular analysis of the EWSR1 gene rearrangement using fluorescent in situ hybridization (FISH) technique. We investigated the diagnostic value of combined CD99 immunostaining and EWSR1 t(22q12) alteration using a dual-color, break-apart rearrangement probe in forty-one formalin-fixed paraffin-embedded (FFPE) tissue samples from pediatric and adult patients diagnosed with EPS. IHC was performed in all cases using the CD99 antibody and showed a positivity of 92.7% in the enrolled cases (38/41) followed by FISH analysis where 48.8% of the cases (20/41) were rearranged. Sensitivity and specificity for IHC assays were 88% and 58%, respectively. Notably, FISH had a sensitivity of 100% and a specificity of 87%. In addition, CD99 positivity was found to correlate with EWSR1 rearrangement (p<0.05). This report shows that FISH has better sensitivity and specificity than IHC in the Moroccan population, and supports its combination with CD99 immunostaining as diagnostic biomarkers for this rare malignant entity.”

Desmoplastic Small Round Cell Tumors: Cytologic, Histologic, and Immunohistochemical Features

2006 ◽  
Vol 130 (5) ◽  
pp. 728-732 ◽  
Author(s):  
Fuju Chang
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Cavity ◽  
Cell Tumor ◽  
Round Cell ◽  
Cytologic Diagnosis ◽  
Small Round Cell ◽  
Karyotypic Abnormality ◽  
The Family ◽  
Cytogenetic Profile ◽  
Round Cell Tumors

Abstract Desmoplastic small round cell tumor (DSRCT) is a recently recognized clinicopathologic entity that has a predilection for adolescent males and usually affects the abdominal cavity. Due to its uncommon nature, many pathologists lack experience with this tumor. The literature regarding DSRCT is reviewed with special attention to its histologic and cytologic diagnosis. Morphologic features of DSRCT and its immunohistochemical and cytogenetic profile are summarized and differential diagnosis with other small round cell tumors is discussed. As observed by both histologic and cytologic examinations, small round blue cells and fibrosclerotic stroma are the striking morphologic features of DSRCT. The typical immunohistochemical profile is characterized by coexpression of epithelial, mesenchymal, myogenic, and neural markers. Cytogenetically, this tumor harbors a specific karyotypic abnormality, namely t(11;22)(p13;q12). These features distinguish DSRCT from other members of the family of small round cell tumors.

Value of cytogenetics in the differential diagnosis of the small round cell tumors of childhood

1992 ◽  
Vol 20 (2) ◽  
pp. 130-135 ◽  
Author(s):  
Laura Sainati ◽  
Mario Stella ◽  
Anna Montaldi ◽  
Sonia Bolcato ◽  
Nicola Guercini ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Round Cell ◽  
Small Round Cell ◽  
Round Cell Tumors

scholarly journals Epidemiological Aspects and Differential Diagnosis of the Cutaneous Round Cell Tumors in Dogs

2017 ◽  
Vol 74 (1) ◽  
pp. 64
Author(s):  
Roxana CORA ◽  
Adrian Florin GAL ◽  
Marian TAULESCU ◽  
Flaviu TABARAN ◽  
Andras NAGY ◽  
...  
Keyword(s):  
Mast Cell ◽  
Differential Diagnosis ◽  
Epidemiological Data ◽  
Cell Tumor ◽  
Tumor Type ◽  
Round Cell ◽  
Cutaneous Lesions ◽  
Stray Dogs ◽  
Mast Cell Tumor ◽  
Round Cell Tumors

Round cell neoplasms (RCNs) are frequent cutaneous lesions in dogs, with high percentages among skin tumors. In this category are included histiocytoma, mast cell tumor, plasmacytoma, lymphoma and transmissible venereal tumor. The aim of the study was to perform an epidemiological study with reference to the cutaneous round cell tumors in a period of 10 years in the Department of Pathology (Faculty of Veterinary Medicine, Cluj-Napoca, Romania). Additionally, in the recorded cases with round cell tumors (mast cell tumor, histiocytoma and lymphoma) we described the main histological and cytological features. The epidemiological data were collected from the records of Pathology Department between 2005-2014. The investigation included dogs diagnosed with cutaneous round cell neoplasms, following necropsy analysis or assessment of biopsies or cytological samples. All collected specimens were analyzed by histopathological and/or cytological techniques. The staining used for histological investigation were Hematoxylin-eosin, Masson’s trichrome and Toluidine blue, whereas Diff Quik and Wright methods were utilized in cytological specimens. The distribution of the cutaneous round cell tumors in relation to age, breed and sex was also assessed. The most frequent round cell tumor type was the mast cell tumor (19.54%) followed by histiocytoma (11.33%) and lymphoma (1.98%). The round cell tumors recorded were equally distributed in both males and females. Concerning the distribution of cutaneous RCNs by age (average age), histiocytoma occurred in 5 years old subjects, mast cell tumor in 11.9 years old subjects, and lymphoma in 6 years old subjects. Mast cell tumor was more frequent in stray dogs and Boxer breed, while histiocytoma occurred more commonly in stray dogs. Histological and cytological analysis was mandatory to perform the differential diagnosis between RCNs. Microscopic details concerning cytoplasm and nucleus of tumoral cells, together with the displaying mode in histological specimens may reveal the type of RCN. Cutaneous round cell tumors had an increased incidence, aspect observed in other reports too. The differential diagnosis has to rely on some specific microscopical features that can suggest the type of RCN.

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