scholarly journals Pancreatic Mucinous Cystic Neoplasms with Sarcomatous Stroma: Molecular Evidence for Monoclonal Origin with Subsequent Divergence of the Epithelial and Sarcomatous Components

2000 ◽  
Vol 13 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Wiebren van den Berg ◽  
Metin Tascilar ◽  
G. Johan A Offerhaus ◽  
Jorge Albores-Saavedra ◽  
Bruce M Wenig ◽  
...  
Keyword(s):  
Molecular Evidence ◽  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms

An Unusual Case of Mucinous Cystic Neoplasms of the Pancreas at Pregnancy

2020 ◽  
Vol 03 (03) ◽  
Author(s):  
Misgav Rottenstreich ◽  
Reut Rotem ◽  
Menahem Ben-Haim ◽  
Sorina Grisaru-Granovsky ◽  
Orna Reichman A ◽  
...  
Keyword(s):  
Unusual Case ◽  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms

Mesenteric and Retroperitoneal Mucinous Cystic Neoplasms: A Case Series

2021 ◽  
pp. 106689692199353
Author(s):  
Benjamin J. Van Treeck ◽  
Rachel K. Horton ◽  
Hee Eun Lee ◽  
Christophe Rosty ◽  
Rish K. Pai ◽  
...  
Keyword(s):  
Case Reports ◽  
Primordial Germ Cells ◽  
Case Series ◽  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms ◽  
Abdominal Tumors ◽  
Keratin 19 ◽  
Liver And Pancreas ◽  
Mucinous Epithelium ◽  
Keratin 7

Aims. Mucinous cystic neoplasms (MCNs) are cystic neoplasms with mucinous epithelium surrounded by ovarian-like stroma. Extraovarian MCN occurring in the liver and pancreas have been well characterized. However, only rare case reports of MCN arising outside of these locations have been reported. MCNs arising in unusual locations should enter the differential diagnosis of mucinous intra-abdominal tumors and must be distinguished from more common mimics. Therefore, we aimed to examine a series of MCNs of the retroperitoneum and mesentery to characterize the clinicopathologic features of this entity. Methods and results. Seven MCNs arising in the abdominal mesentery or retroperitoneum were retrospectively identified. A clinicopathologic, histologic, and immunohistochemical (keratin 7, keratin 19, keratin 20, calretinin, inhibin-α, steroidogenic factor-1 (SF-1), estrogen receptor (ER), progesterone receptor (PR), PAX8, CDX2, and CD10) analysis was performed. All 7 MCNs were from females with a median age of 41 years old and a median size of 8 cm. All cases demonstrated mucinous with or without concomitant non-mucinous epithelium overlying spindle cell ovarian-like stroma. Luteinized cells were noted. The epithelium was positive for keratin 7 and keratin 19 in all 7 cases, while the stroma expressed ER, PR, and SF-1 in all cases stained. Calretinin was focally positive in the stroma of 3 of 7 cases, while inhibin-α was focally expressed in 5 of 6 cases. Conclusions. These results highlight the clinicopathologic, histologic, and immunophenotypic similarities between MCNs of the mesentery, retroperitoneum, pancreas, and liver. Overlapping features suggest a common histogenesis for all MCNs, which could include periductal fetal mesenchyme, aberrant migration of primordial germ cells, or abnormal differentiation or metaplasia of the embryonic coelomic epithelium.

scholarly journals Experience-based surgical approach to pancreatic mucinous cystic neoplasms with ovarian-type stroma

2017 ◽  
Author(s):  
Chang Kang ◽  
Akira Matsushita ◽  
Ho Hwang ◽  
Yoko Matsuda ◽  
Hyunki Kim ◽  
...  
Keyword(s):  
Surgical Approach ◽  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms

Sendai and Fukuoka Consensus Guidelines Identify Advanced Neoplasia in Patients With Suspected Mucinous Cystic Neoplasms of the Pancreas

2015 ◽  
Vol 13 (10) ◽  
pp. 1808-1815 ◽  
Author(s):  
Pavlos Kaimakliotis ◽  
Brian Riff ◽  
Kamron Pourmand ◽  
Vinay Chandrasekhara ◽  
Emma E. Furth ◽  
...  
Keyword(s):  
Consensus Guidelines ◽  
Cystic Neoplasms ◽  
Advanced Neoplasia ◽  
Mucinous Cystic Neoplasms

Intralobular Distribution of Ovarian-like Stroma in Pancreatic Mucinous Cystic Neoplasms: Hypothesis on Its Tumorigenesis

2021 ◽  
Author(s):  
Yuki Fukumura ◽  
Yuko Kinowaki ◽  
Yoko Matsuda ◽  
Masaru Takase ◽  
Momoko Tonosaki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Wnt Pathway ◽  
Smooth Muscle Actin ◽  
Mucinous Cystic Neoplasm ◽  
Cystic Neoplasm ◽  
Pancreatic Ducts ◽  
Low Grade ◽  
Muscle Actin ◽  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms

Abstract Pancreatic mucinous cystic neoplasm (MCN) harbors two histological components, tumor epithelia and ovarian-like stroma (OLS). To examine the tumorigenesis of pancreatic MCNs, this study analyzed the distribution, amount, immunohistochemical phenotype, presence of theca cells of the OLS, and the alteration of tumor epithelium of 29 surgically resected MCN cases and compared them with tumor sizes. Non-mucinous type epithelium was present in all low-grade MCNs but its ratio decreased with tumor size (p < 0.05), suggesting that epithelial mucinous changes are a progression phenomenon. The intralobular distribution of OLS was observed in 27.6 % of MCN cases and its existence related to a smaller size (p< 0.05), suggesting intralobular generation of MCNs. Nuclear expression of β-catenin was observed for OLS of everywhere, suggesting consistent activation of the Wnt pathway for OLS. Three MCN cases (10.3%) contained a-smooth muscle actin (SMA)-negative OLS, where OLS surrounding dilated pancreatic ducts or MCN cysts were a-SMA-positive and otherwise negative, suggesting that a-SMA-positivity is an acquired phenomenon of OLS. With this study, we could hypothesize that pancreatic MCNs may generate intralobularly. Epithelial mucinous change and a-SMA-positivity of OLS may be progression phenomena. This is the first study to show the intralobular distribution of OLS.

Mucinous Cystic Neoplasms of the Pancreas: Definition of Preoperative Imaging Criteria for High-Risk Lesions

Pancreatology ◽  
2011 ◽  
Vol 11 (5) ◽  
pp. 495-499 ◽  
Author(s):  
Yann Le Baleur ◽  
Anne Couvelard ◽  
Marie Pierre Vullierme ◽  
Alain Sauvanet ◽  
Pascal Hammel ◽  
...  
Keyword(s):  
High Risk ◽  
Preoperative Imaging ◽  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms ◽  
Definition Of

Molecular Pathology of Mucinous Cystic Neoplasms

2021 ◽  
pp. 1-2
Author(s):  
Andrea Cacciato Insilla ◽  
Mirella Giordano ◽  
Daniela Campani
Keyword(s):  
Molecular Pathology ◽  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms

Mucinous cystic neoplasms of the pancreas in the modern era. Experience with 707 patients

2020 ◽  
Vol 220 (6) ◽  
pp. 1433-1437
Author(s):  
Maria Ahmad ◽  
Felipe B. Maegawa ◽  
Elizabeth De La Rosa ◽  
Brian Davis ◽  
Alan Tyroch ◽  
...  
Keyword(s):  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms ◽  
Modern Era

scholarly journals Mucinous Cystic Neoplasms of the Liver and Extrahepatic Biliary Tract

2018 ◽  
Author(s):  
Dzeina Mezale ◽  
Ilze Strumfa ◽  
Andrejs Vanags ◽  
Guntis Bahs ◽  
Boriss Strumfs ◽  
...  
Keyword(s):  
Biliary Tract ◽  
Cystic Neoplasms ◽  
Mucinous Cystic Neoplasms
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