scholarly journals Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangements

2007 ◽  
Vol 20 (7) ◽  
pp. 779-787 ◽  
Author(s):  
Sien-Yi Sheu ◽  
Suzan Schwertheim ◽  
Karl Worm ◽  
Florian Grabellus ◽  
Kurt Werner Schmid
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Braf Mutation ◽  
Papillary Thyroid ◽  
Diffuse Sclerosing Variant

Surgical management of papillary thyroid carcinoma according to BRAF mutation

2017 ◽  
Vol 72 ◽  
pp. S110-S111
Author(s):  
A. Polyakov ◽  
N. Volchenko ◽  
P. Nikiforovich ◽  
E. Slavnova ◽  
A. Kudryavtseva ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Surgical Management ◽  
Braf Mutation ◽  
Papillary Thyroid

Two Cases of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma

2008 ◽  
Vol 23 (6) ◽  
pp. 430
Author(s):  
Hee Kwan Won ◽  
Myoung Jun Lee ◽  
Joo Ho Park ◽  
In Girl Song ◽  
Go Eun Lee ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Diffuse Sclerosing Variant

scholarly journals A Case Report Demonstrating How the Clinical Presentation of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma Can Mimic Benign Riedel’s Thyroiditis

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Jennifer Walsh ◽  
Tomas P. Griffin ◽  
Carmel B. Ryan ◽  
James Fitzgibbon ◽  
Patrick Sheahan ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Inflammatory Cells ◽  
Needle Aspiration ◽  
Neck Mass ◽  
Papillary Thyroid ◽  
Riedel’S Thyroiditis ◽  
Diffuse Sclerosing Variant ◽  
Riedel's Thyroiditis

A 44-year-old female presented with a two-month history of a neck mass, sore throat, hoarseness, and intermittent dysphagia. Examination revealed a “woody” hard swelling arising from the right lobe of the thyroid. Clinically this was felt to be classical Riedel’s thyroiditis (RT). Thyroid ultrasound showed a diffusely enlarged, low echogenicity thyroid with a multinodular goitre. An abnormal nodule extending across the isthmus was noted. Following a nondiagnostic fine needle aspiration, an open core biopsy was performed. This showed dense sclerotic fibrosis punctuated by nodular mononuclear inflammatory cells, which obscured follicular epithelial cells consistent with a fibrosing thyroiditis (Riedel’s thyroiditis). A biopsy of pretracheal lymph nodes showed a sclerotic process throughout the lymph nodes and nests of epithelium bands with squamous differentiation obscured by a fibrous process. These findings raised the differential diagnosis of diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) with metastasis to lymph nodes. A total thyroidectomy and pretracheal lymph node dissection were performed. The final histological diagnosis was DSV-PTC. When managing a patient with presumed RT it is important to consider malignancy in the differential. DSV-PTC is one of the more aggressive forms of thyroid cancer but with early diagnosis and appropriate treatment patients may have excellent outcomes.

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