scholarly journals Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma

2007 ◽  
Vol 20 (7) ◽  
pp. 749-759 ◽  
Author(s):  
Robert Nakayama ◽  
Takeshi Nemoto ◽  
Hiro Takahashi ◽  
Tsutomu Ohta ◽  
Akira Kawai ◽  
...  
Keyword(s):  
Gene Expression ◽  
Soft Tissue ◽  
Expression Analysis ◽  
Malignant Fibrous Histiocytoma ◽  
Gene Expression Analysis ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas

scholarly journals Feasibility of using gene expression analysis to study canine soft tissue sarcomas

2010 ◽  
Vol 21 (11-12) ◽  
pp. 577-582 ◽  
Author(s):  
Jennifer A. Mahoney ◽  
Julie C. Fisher ◽  
Stacey A. Snyder ◽  
Marlene L. Hauck
Keyword(s):  
Gene Expression ◽  
Soft Tissue ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Soft Tissue Sarcomas

scholarly journals Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas

2013 ◽  
Vol 14 (12) ◽  
pp. r137 ◽  
Author(s):  
Marcus Renner ◽  
Thomas Wolf ◽  
Hannah Meyer ◽  
Wolfgang Hartmann ◽  
Roland Penzel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Soft Tissue ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Soft Tissue Sarcomas ◽  
High Grade

LOCAL RECURRENCES AFTER THE TREATMENT OF SOFT TISSUE MALIGNANT FIBROUS HISTIOCYTOMA (UNCLASSIFIEDPLEOMORPHIC SARCOMA) OF THE LIMBS

2019 ◽  
Vol 72 (8) ◽  
pp. 1523-1526
Author(s):  
Oleksandr O. Lytvynenko ◽  
Volodymyr F. Konovalenko ◽  
Anton Yu. Ryzhov
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Survival Rates ◽  
Soft Tissue Sarcomas ◽  
Primary Treatment ◽  
Radical Excision ◽  
Local Recurrences ◽  
Results Of Treatment

Introduction: The treatment of patients with malignant fibrous histiocytoma as well as other soft tissue sarcomas is not sufficiently effective up to date, and has largely changed and reflects the alterations, occurred in oncology as a whole. The number of amputation decreased over the last 10-15 years. Some researchers associate the improvement of treatment outcomes with the development of combined and complex methods. The aim of the study is an improvement of the results of treatment of patients with soft tissue malignant histiocytoma on the basis of determination of factors, influencing local recurrence development. Materials and methods: The basis of our study was a comprehensive analysis of examination and treatment results of 130 patients with MFH of the soft tissue of limbs, of them in 84 patients (64.6%) the recurrences developed. The group included 45 (53.6%) males and 39 (46.4%) females. The major part of patients – 82.1% (60 patients) were older than 40 years. Results and conclusions: The number of recurrences after the treatment in general surgical facilities is 86.9%, whereas in the patients after the treatment in the specialized oncological facilities this figure is twice lower (40%). The characteristic of the medical facility where the patient receives his/her primary treatment largely affects the development of local recurrences, patients’ quality of life and overall survival rates. The surgical method remains the leading modality in the treatment of MFH of ST. Wide and radical excision of tumors in the specialized oncological facilities allows achieving better survival outcomes of the patients.

scholarly journals Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature

2020 ◽  
Vol 17 (4) ◽  
pp. 1426
Author(s):  
Khrystyna Zhurakivska ◽  
Giuseppe Troiano ◽  
Marco Montella ◽  
Lorenzo Lo Muzio ◽  
Luca Fiorillo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Soft Tissues ◽  
Fibrous Histiocytoma ◽  
Case Reports ◽  
Soft Tissue Sarcomas ◽  
Clinical Aspects ◽  
Risk Of Death ◽  
Short Period

Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous histiocytoma belongs to the group of soft tissue sarcomas and makes up less than 10% of soft tissue sarcomas. For therapeutic purposes, complete exeresis of the lesion (macroscopic and microscopic) is performed because they have frequent recurrences. As for complementary therapy in addition to surgery, neither radiotherapy nor chemotherapy have been shown to reduce the risk of death related to the disease. Often patients complain of a swelling that grows in a short period of time. It is quite common for patients to report trauma in the area, which is not the cause, but rather the event that allows diagnosis. The mass usually does not cause pain unless it compresses an adjacent nerve structure. The aim of this study is to systematically review the scientific literature in order to identify the most recent studies concerning malignant fibrous histiocytomas localized in oral soft tissues and report their main data. The main outcomes of this study concern the immunohistochemical, molecular, and clinical aspects of this pathology. A systematic review of articles in the electronic databases pubmed, Scopus, and Web of Science was performed. After the selection process, 11 studies met the inclusion criteria and were included in the review. The mean age of the patients was 50.8 years old. The lesions affected various parts of the oral cavity, showing predominantly storiform–pleomorphic patterns. All cases except one were treated with surgical resection and radiation therapy. Although some data emerged from this review, they remain limited to a few case reports. Further studies are necessary in order to standardize the approach to patients affected by oral malignant fibrous histiocytoma (MFH).

scholarly journals Primary Malignant Fibrous Histiocytoma of the Lung: A Case Report

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
I. Tsangaridou ◽  
G. Papamihalis ◽  
K. Stathopoulos ◽  
O. Konstantinopoulos ◽  
L. Thanos
Keyword(s):  
Radiation Therapy ◽  
Case Report ◽  
Soft Tissue ◽  
Surgical Resection ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Distant Recurrence ◽  
Local Relapse ◽  
Metastatic Lesions

Primary malignant fibrous histiocytoma (MFH) of the lung is extremely rare although it is among the most common soft tissue sarcomas in adults. Surgery is the primary mode of therapy, with high rates of local and distant recurrence, while radiation therapy appears to be a very useful adjunct, decreasing local relapse. We report a case of primary malignant fibrous histiocytoma of the lung. Fourteen years after surgical resection, the patient is still alive although with multiple metastatic lesions throughout his body.

scholarly journals Malignant Fibrous Histiocytoma and Malignant Histiocytosis in the Dog—Convergent or Divergent Phenotypic Differentiation?

1996 ◽  
Vol 33 (6) ◽  
pp. 713-716 ◽  
Author(s):  
R. L. Kerlin ◽  
M. J. Hendrick
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
University Of Pennsylvania ◽  
Cell Of Origin ◽  
Malignant Histiocytosis ◽  
Phenotypic Differentiation ◽  
Histologic Evaluation ◽  
The University

Malignant fibrous histiocytoma (MFH) malignant histiocytosis (MH) are neoplasms with different histologic appearances and consequently a different putative cell of origin. Recently, the biopsy and necropsy services at the University of Pennsylvania have seen many canine soft tissue sarcomas that have the gross and histologic appearances of both MH and MFH within the same animal. A retrospective histologic evaluation of 263 cases diagnosed originally as either MH or MFH reclassified these neoplasms into 77 cases that were exclusively MH, 110 cases exclusively MFH, and 76 cases with features of both MH and MFH. Age, sex, breed predispositions, and distribution of lesions in organs were remarkably similar between the two categories. The hybrid neoplasms containing MH-like and MFH-like regions may be the result of divergent or convergent phenotypic differentiation.

scholarly journals Primary Pulmonary Malignant Fibrous Histiocytoma

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Devin P. Patel ◽  
Yogesh S. Gandhi ◽  
Keith E. Sommers ◽  
Devanand Mangar ◽  
Enrico M. Camporesi
Keyword(s):  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Primary Tumor ◽  
Rare Case ◽  
Diagnostic Procedure ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Surgical Excision

Malignant fibrous histiocytoma (MFH) is one of the most common adult soft tissue sarcomas. MFH is very aggressive and is most often found in the extremities and the retroperitoneum, but it can manifest at other sites. Though the lungs are the most common sites of metastasis, they rarely present there as a primary tumor. Our report describes a rare case of a primary MFH tumor in the lung. Careful diagnostic procedure should be followed to ensure the tumor does not have extrapulmonary origins. Though MFH is highly invasive and deadly, surgical excision of the tumor has been shown to be successful.

Gene expression analysis of human soft tissue leiomyosarcomas

2003 ◽  
Vol 34 (6) ◽  
pp. 549-558 ◽  
Author(s):  
Baoguo Ren ◽  
Yan Ping Yu ◽  
Ling Jing ◽  
Lijun Liu ◽  
George K Michalopoulos ◽  
...  
Keyword(s):  
Gene Expression ◽  
Soft Tissue ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Human Soft Tissue
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