scholarly journals Stromal CD10 expression in invasive breast carcinoma correlates with poor prognosis, estrogen receptor negativity, and high grade

2006 ◽  
Vol 20 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Nikita A Makretsov ◽  
Malcolm Hayes ◽  
Beverley A Carter ◽  
Shahriar Dabiri ◽  
C Blake Gilks ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Breast Carcinoma ◽  
Poor Prognosis ◽  
Invasive Breast Carcinoma ◽  
High Grade ◽  
Cd10 Expression ◽  
Estrogen Receptor Negativity ◽  
Receptor Negativity

scholarly journals A study on correlation of histopathological grade with hormone receptor and HER2/neu status in invasive breast carcinoma at a tertiary care centre of Barak valley

2021 ◽  
Vol 9 (5) ◽  
pp. 1355
Author(s):  
Sailendra Kumar Thakuria ◽  
Suchismita Roy ◽  
Monoj K. Deka ◽  
Anuradha Talukdar ◽  
Shah Alam Sheikh
Keyword(s):  
Estrogen Receptor ◽  
Breast Carcinoma ◽  
Hormone Receptors ◽  
Invasive Breast Carcinoma ◽  
Histological Evaluation ◽  
High Grade ◽  
Breast Carcinomas ◽  
Histopathological Grade ◽  
Positive Correlation ◽  
Common Malignancy

Background: Breast carcinoma is the most common malignancy occurring in females worldwide while in India it is the 2nd most common malignancy occurring after cervical cancer in females. The treatment modalities and prognosis of breast carcinoma depend largely on their hormone receptors (estrogen and progesterone receptors) and human epidermal growth factor receptor 2 (HER2/neu) status. The aim of this study was to correlate the receptor status in invasive breast carcinoma with histopathological grading of the tumor.Methods: This is a retrospective study carried out in the department of pathology, Silchar medical college and hospital, Cachar from January 2019 to December 2020. A total of 69 cases were considered for the study, selected on the basis of inclusion and exclusion criteria. Histomorphology grading in invasive ductal breast carcinomas was done along with the status of estrogen receptor (ER), progesterone receptor (PR) and HER2/neu.Results: The present study comprised of total of 69 infiltrating breast carcinoma cases. Out of all 51% cases were found to be in 4th decade of life. The most common type found in the study was invasive ductal carcinoma (not otherwise specified) seen in 86.96% cases. Maximum 41.67% of cases were histologically classified as grade III. A positive correlation was found between histological grading and immunohistochemistry of hormone receptors (ER, PR) and HER2/neu status.Conclusions: From the present study, it can be concluded that there is a positive correlation between histopathological grade and hormone receptors status and HER2/neu.The estrogen receptor and progestrone receptor were found negative in high grade disease on histological evaluation. Triple negative breast carcinomas have poorer prognosis as they tend to be of high grade.

Immunohistochemical and Clinicopathologic Characteristics of Invasive Ductal Carcinoma of Breast With Micropapillary Carcinoma Component

2005 ◽  
Vol 129 (10) ◽  
pp. 1277-1282 ◽  
Author(s):  
Mi-Jung Kim ◽  
Gyungyub Gong ◽  
Hee Jae Joo ◽  
Se-Hyun Ahn ◽  
Jae Y. Ro
Keyword(s):  
Estrogen Receptor ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Breast Carcinoma ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Invasive Breast Carcinoma ◽  
Nodal Metastases ◽  
Micropapillary Carcinoma ◽  
Epidermal Growth

Abstract Context.—A micropapillary carcinoma (MC) component is generally considered to behave aggressively. Although several reports have described the prognostic significance of MC in breast carcinomas, immunohistochemical findings of MC, especially as compared to non-MC, are rarely described. Objective.—We compared clinicopathologic and immunohistochemical findings between 38 cases of invasive breast carcinoma with an MC component (IMC) and 217 cases of invasive breast carcinoma without an MC component (NIMC). Design.—We constructed a tissue microarray from 38 cases of IMC and performed immunohistochemical stainings for cytokeratin (CK) 7, CK20, estrogen receptor, progesterone receptor, p53, c-Erb-B2, CD34, CK5, epidermal growth factor receptor, and c-Kit in both MC and non-MC components. Results.—Cases with IMC were associated with greater tumor size, more frequent lymphovascular invasion, nodal metastases, greater mean numbers of positive lymph nodes, and higher stage than those with NIMC, but were not associated with poorer survival rates. On immunohistochemistry, only p53 reactivity was statistically different between MC and non-MC components in IMC cases. Estrogen receptor positivity tended to be lower in MC than non-MC, but the difference was not significant. Most of the MCs and non-MCs in IMC cases were positive for CK7, but none of them were positive for CK20, CK5, epidermal growth factor receptor, or c-Kit. Conclusions.—Based on the frequent nodal metastases and association with higher stage found in IMC as compared with NIMC cases, as well as higher p53 positivity and lower frequency of estrogen receptor expression, MC could be considered an aggressive histologic type of breast carcinoma. In both MC and non-MC components in IMC cases, no basallike immunostaining pattern was detected.

scholarly journals 8p22 MTUS1 Gene Product ATIP3 Is a Novel Anti-Mitotic Protein Underexpressed in Invasive Breast Carcinoma of Poor Prognosis

PLoS ONE ◽  
2009 ◽  
Vol 4 (10) ◽  
pp. e7239 ◽  
Author(s):  
Sylvie Rodrigues-Ferreira ◽  
Anne Di Tommaso ◽  
Ariane Dimitrov ◽  
Sylvie Cazaubon ◽  
Nadège Gruel ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Gene Product ◽  
Poor Prognosis ◽  
Invasive Breast Carcinoma

Stromal Cd10 expression as a potential novel prognostic factor in invasive breast carcinoma

Pathology ◽  
2017 ◽  
Vol 49 ◽  
pp. S64
Author(s):  
Azza Rizk ◽  
Eman Abdelzaher ◽  
Ahmed Gowily ◽  
Rana Elsaka
Keyword(s):  
Prognostic Factor ◽  
Breast Carcinoma ◽  
Invasive Breast Carcinoma ◽  
Cd10 Expression

scholarly journals PI3K Pathway Activation in High-Grade Ductal Carcinoma In Situ—Implications for Progression to Invasive Breast Carcinoma

2014 ◽  
Vol 20 (9) ◽  
pp. 2326-2337 ◽  
Author(s):  
Rita A. Sakr ◽  
Britta Weigelt ◽  
Sarat Chandarlapaty ◽  
Victor P. Andrade ◽  
Elena Guerini-Rocco ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Pi3k Pathway ◽  
Invasive Breast Carcinoma ◽  
High Grade ◽  
Pathway Activation

scholarly journals Dual-Color Fluorescence In Situ Hybridization Reveals an Association of Chromosome 8q22 but Not 8p21 Imbalance with High Grade Invasive Breast Carcinoma

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e70790 ◽  
Author(s):  
Logan C. Walker ◽  
Margaret McDonald ◽  
J. Elisabeth Wells ◽  
Gavin C. Harris ◽  
Bridget A. Robinson ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Breast Carcinoma ◽  
Fluorescence In Situ Hybridization ◽  
Invasive Breast Carcinoma ◽  
High Grade ◽  
Dual Color
Sign in / Sign up

Export Citation Format

Share Document