scholarly journals Id proteins expression in prostate cancer: high-level expression of Id-4 in primary prostate cancer is associated with development of metastases

2006 ◽  
Vol 19 (7) ◽  
pp. 931-941 ◽  
Author(s):  
Hiu-Fung Yuen ◽  
Chee-Wai Chua ◽  
Yuen-Piu Chan ◽  
Yong-Chuan Wong ◽  
Xianghong Wang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Level Expression ◽  
Id Proteins ◽  
Primary Prostate Cancer ◽  
High Level

High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB

2005 ◽  
Vol 206 (2) ◽  
pp. 214-219 ◽  
Author(s):  
Tine Van de Sande ◽  
Tania Roskams ◽  
Evelyne Lerut ◽  
Steven Joniau ◽  
Hein Van Poppel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fatty Acid ◽  
Nuclear Localization ◽  
Fatty Acid Synthase ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
High Level Expression ◽  
High Level ◽  
Cancer Tissues

High-level expression of forkhead-box protein A1 in metastatic prostate cancer

2011 ◽  
Vol 58 (5) ◽  
pp. 766-772 ◽  
Author(s):  
Rohit K Jain ◽  
Rutika J Mehta ◽  
Harikrishna Nakshatri ◽  
Muhammad T Idrees ◽  
Sunil S Badve
Keyword(s):  
Prostate Cancer ◽  
Metastatic Prostate Cancer ◽  
High Level Expression ◽  
Forkhead Box ◽  
High Level

scholarly journals High level expression of STAG1/PMEPA1 in an androgen-independent prostate cancer PC3 subclone

2007 ◽  
Vol 12 (3) ◽  
Author(s):  
Yoshifumi Hirokawa ◽  
Akimitsu Takagi ◽  
Katsunori Uchida ◽  
Yuji Kozuka ◽  
Misao Yoneda ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Differentially Expressed Genes ◽  
Nude Mice ◽  
The Other ◽  
High Level Expression ◽  
Isolation And Characterization ◽  
Epithelial Phenotype ◽  
High Level ◽  
Androgen Independent

AbstractIn this paper, we describe the isolation and characterization of two PC3 subclones. One subclone, mr, showed an epithelial phenotype, the other, M1, showed a sarcomatous morphology. Transplanted into nude mice, mr developed tumors at a dramatically faster rate than M1. Comparing the two subclones, differentially expressed genes were identified, including E-cadherin, IL-8 and STAG1/PMEPA1. These genes were expressed at higher levels in mr than in M1.

805: High-Level Cyclin D1 is Associated with High Gleason Grade and Predicts Worse Biochemical-Free Survival in Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Rile Li ◽  
Hong Dai ◽  
Thomas M. Wheeler ◽  
Anna Frolov ◽  
Gustavo Ayala
Keyword(s):  
Prostate Cancer ◽  
Cyclin D1 ◽  
Gleason Grade ◽  
Free Survival ◽  
High Level

PET/CT WITH 68GA-PSMA-11 IN DETECTION OF PRIMARY TUMOR AND RECURRENCE OF PROSTATE CANCER

2018 ◽  
Vol 64 (6) ◽  
pp. 799-804
Author(s):  
Darya Ryzhkova ◽  
M. Poyda
Keyword(s):  
Prostate Cancer ◽  
Primary Tumor ◽  
Biochemical Recurrence ◽  
Whole Body ◽  
Negative Results ◽  
Primary Prostate Cancer ◽  
Pet Ct ◽  
The Relationship ◽  
Positive Results ◽  
T Category

Purpose: To study the diagnostic value of PET-CT with 68Ga-PSMA-11 in the diagnosis of a primary prostate cancer, preoperative staging, and the detection of recurrence of prostate cancer (PCa). Methods: 28 patients aged 64.7 ± 8.74 years were included. 10 patients primary prostate cancer, and 18 patients with biochemical recurrence of the disease after radical treatment were examined. All patients underwent PET-CT with 68Ga-PSMA-11 according the whole body protocol. Interpretation of images was performed visually and quantitatively by calculation of SUL max. Results: High focal or diffuse 68Ga-PSMA-11 uptake was found in prostate parenchyma in patients with primary prostate cancer. Additionally metastases in regional lymph nodes were diagnosed in 4 patients and bone metastases were found in one patient. The correlation between 68Ga-PSMA-11 uptake level and Gleason index in the primary tumor (R Spearmen = 0.25, p = 0.57) was not observed. PET-positive results were obtained in 14 patients and PET-negative results in 4 patients with biochemical recurrence of PCa. The relationship between the frequency of PET-positive results and Gleason index was not revealed (R Spearmen = 0.2, p = 0.39). We found a weak but significant correlation between the frequency of PET-positive results and the prostate tumor stage according to the T category (R Spearmen = 0.49, p = 0.049). In patients with low values of PSA (less than 1.0 ng/ml) in 4 out of 9 cases, PET-negative results were obtained. In patients with PSA level more than 1.0 ng/ml PET-positive results were obtained in all cases. Conclusions: PET/CT with 68Ga-PSMA-11 allows to diagnose the primary prostate cancer, to establish the stage of the disease in categories N and M, and also to determine the localization and dissemination of the tumor in patients with biochemical recurrence of prostate cancer. The relationship between 68Ga-PSMA-11 uptake in primary tumor and Gleason index was not found. The probability of obtaining PET-positive results in cases of biochemical recurrence is affected by a PSA level above 1 ng/ml and a high stage of the disease according to the T category (T3-T4).

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