scholarly journals Distinguishing well-differentiated hepatocellular carcinoma from benign liver by the physical features of fine-needle aspirates

2004 ◽  
Vol 17 (7) ◽  
pp. 798-802 ◽  
Author(s):  
Grace C H Yang ◽  
Guang-Yu Yang ◽  
Liang-Che Tao
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Well Differentiated ◽  
Physical Features ◽  
Benign Liver

Use of CD34 and Factor VIII To Diagnose Hepatocellular Carcinoma on Fine Needle Aspirates

1998 ◽  
Vol 42 (3) ◽  
pp. 691-696 ◽  
Author(s):  
Shoshana Gottschalk-Sabag ◽  
Noemi Ron ◽  
Tzipporah Glick
Keyword(s):  
Hepatocellular Carcinoma ◽  
Factor Viii ◽  
Fine Needle ◽  
Fine Needle Aspirates

FLOW CYTOMETRIC DNA CONTENT IN FINE NEEDLE ASPIRATES OF HEPATOCELLULAR CARCINOMA TO ASSESS PROGNOSIS

1991 ◽  
Vol 73 (2-3) ◽  
pp. 42a-42a
Author(s):  
Michèle Perrin-Cottier ◽  
Claude Jouffre ◽  
Odile Sabido ◽  
Ivan Maubon ◽  
Olivier Dumas ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Content ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Flow Cytometric

Fine-Needle Aspirates of Adenocarcinoma/Metastatic Carcinoma That Resemble Hepatocellular Carcinoma: Correlating Cytologic Features and Performance in the College of American Pathologists Nongynecologic Cytology Program

2005 ◽  
Vol 129 (10) ◽  
pp. 1217-1221
Author(s):  
Andrew A. Renshaw ◽  
Jennifer Haja ◽  
David C. Wilbur ◽  
Theodore R. Miller
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fine Needle Aspiration ◽  
Needle Aspiration ◽  
Metastatic Carcinoma ◽  
Time Range ◽  
Fine Needle ◽  
Fine Needle Aspirates ◽  
Granular Cytoplasm ◽  
The Difference ◽  
And Performance

Abstract Context.—The cytologic features of adenocarcinoma/ metastatic carcinoma in liver fine-needle aspirates are well described. We review the cytologic findings from 16 aspirates of adenocarcinoma/metastatic carcinoma that were frequently misclassified as hepatocellular carcinomas and compare them with 17 cases that were rarely misclassified. Objective.—To compare the cytologic features of adenocarcinoma/metastatic carcinoma in fine-needle aspiration specimens of the liver that were frequently misclassified as hepatocellular carcinoma with those of aspirates that were rarely misclassified. Design.—We reviewed a total of 1712 interpretations from 33 different cases of adenocarcinoma/metastatic carcinoma tumor in liver fine-needle aspiration specimens in the College of American Pathologists Nongynecologic Cytology Program and correlated the cytologic features with performance in the program. Results.—Overall, cases that were frequently misclassified as hepatocellular carcinoma were misclassified on average 26% of the time (range, 13%–54%), while infrequently misclassified cases were interpreted as hepatocellular carcinoma on average 0.7% of the time (range, 0%– 3%). The difference was statistically significant (P < .001). On review, cases that were frequently misclassified most often had moderate amounts of granular cytoplasm (16/16 cases) and round nuclei with even chromatin (13/16 cases). Trabeculae (3/16 cases), bare nuclei (2/16 cases), and endothelial wrapping (1/16 cases) were also occasionally present. In contrast, cases that were rarely misclassified were more likely to have areas with cells showing scant cytoplasm that were crowded and overlapped or molded (13/17 cases) and contained dark hyperchromatic chromatin (13/17 cases) compared to cases that were frequently misclassified (P < .001 and P = .002, respectively). Trabeculae (2/17) and bare nuclei (2/17 cases) were also rarely present. Conclusion.—Cases of adenocarcinoma/metastatic carcinoma with moderate amounts of granular cytoplasm and round nuclei with even chromatin are frequently misclassified as hepatocellular carcinoma. Recognition of this problem, attention to cytologic criteria, and frequent use of immunohistochemical studies and core biopsy may help avoid this pitfall.

Cytomorphologic and DNA Cytometric Features of Hepatocellular Carcinoma in Fine Needle Aspirates

1997 ◽  
Vol 41 (2) ◽  
pp. 435-442 ◽  
Author(s):  
Pichet Sampatanukul ◽  
Gregor Mikuz ◽  
Sachapan Israsena ◽  
Kaesorn Vajarapongse ◽  
Hans Feichtinger
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fine Needle ◽  
Fine Needle Aspirates

scholarly journals Cell features and patterns in fine-needle aspirates of hepatocellular carcinoma

Cancer ◽  
1986 ◽  
Vol 58 (2) ◽  
pp. 321-328 ◽  
Author(s):  
Sanai Noguchi ◽  
Reiko Yamamoto ◽  
Masaharu Tatsuta ◽  
Hiroshi Kasugai ◽  
Shigeru Okuda ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fine Needle ◽  
Fine Needle Aspirates

Cytologic aspect of fibrolamellar hepatocellular carcinoma in fine-needle aspirates

1999 ◽  
Vol 21 (3) ◽  
pp. 180-187 ◽  
Author(s):  
Miguel P�rez-Guillermo ◽  
Nuria Alberti Masgrau ◽  
Jos� Garc�a-Solano ◽  
Joaqu�n Sola-P�rez ◽  
Pedro de Agust�n y de Agust�n
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
Fine Needle ◽  
Fine Needle Aspirates
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