scholarly journals High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal carcinoma of the prostate

2018 ◽  
Vol 31 (S1) ◽  
pp. 71-79 ◽  
Author(s):  
Ming Zhou
Keyword(s):  
Ductal Carcinoma ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Carcinoma Of The Prostate

Intraductal Carcinoma of the Prostate Gland With Transmucosal Spread to the Seminal Vesicle: A Lesion Distinct From High-Grade Prostatic Intraepithelial Neoplasia

2007 ◽  
Vol 131 (7) ◽  
pp. 1122-1125 ◽  
Author(s):  
Ronald J. Cohen ◽  
Beverly A. Shannon ◽  
Sydney L. Weinstein
Keyword(s):  
Seminal Vesicle ◽  
Invasive Carcinoma ◽  
Prostate Gland ◽  
Ejaculatory Duct ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Carcinoma Of The Prostate ◽  
High Stage

Abstract Intraductal carcinoma of the prostate (IDC-P) gland represents an intraluminal neoplastic proliferation that is distinct from high-grade prostatic intraepithelial neoplasia (HG-PIN) and almost always coexists with large-volume, high-stage, and high-grade invasive carcinoma. We document an unusual presentation of apparently “early” IDC-P without an aggressive invasive element that, despite being confined to the acinar-ductal system, has gained access to the ejaculatory duct and seminal vesicle by transmucosal spread. This finding confirms that IDC-P, in contrast to HG-PIN, is inherently aggressive and has the ability to spread beyond the prostate gland. In this case, the absence of an aggressive invasive element suggests that IDC-P has most likely evolved within the lumens directly from HG-PIN.

scholarly journals Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia

2012 ◽  
Vol 26 (4) ◽  
pp. 587-603 ◽  
Author(s):  
Tamara L Lotan ◽  
Berrak Gumuskaya ◽  
Hameed Rahimi ◽  
Jessica L Hicks ◽  
Tsuyoshi Iwata ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Protein Loss ◽  
Pten Protein ◽  
Carcinoma Of The Prostate

Do Not Misinterpret Intraductal Carcinoma of the Prostate as High-grade Prostatic Intraepithelial Neoplasia!

2012 ◽  
Vol 62 (3) ◽  
pp. 518-522 ◽  
Author(s):  
Rodolfo Montironi ◽  
Marina Scarpelli ◽  
Liang Cheng ◽  
Antonio Lopez-Beltran ◽  
Ming Zhou ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Carcinoma Of The Prostate

Intraductal Carcinoma of the Prostate: Morphologic Features, Differential Diagnoses, Significance, and Reporting Practices

2015 ◽  
Vol 139 (10) ◽  
pp. 1234-1241 ◽  
Author(s):  
Martin Magers ◽  
Lakshmi Priya Kunju ◽  
Angela Wu
Keyword(s):  
Differential Diagnosis ◽  
Intraepithelial Neoplasia ◽  
Treatment Recommendations ◽  
Prostatic Intraepithelial Neoplasia ◽  
Differential Diagnoses ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Reporting Practices ◽  
Carcinoma Of The Prostate ◽  
Molecular Features

The differential diagnosis for atypical cribriform lesions of the prostate has become increasingly complex and includes intraductal carcinoma of the prostate, high-grade prostatic intraepithelial neoplasia, and atypical intraductal proliferations. In this review, we summarize the morphologic and molecular features and significance of intraductal carcinoma of the prostate. We also summarize our institution's strategy for reporting and treatment recommendations for intraductal carcinoma of the prostate.

Focal Signet Ring Cell High-Grade Prostatic Intraepithelial Neoplasia on Needle Biopsy

2017 ◽  
Vol 25 (4) ◽  
pp. 344-347
Author(s):  
Guang-Qian Xiao ◽  
Pamela D. Unger
Keyword(s):  
Needle Biopsy ◽  
Invasive Carcinoma ◽  
Intraepithelial Neoplasia ◽  
Signet Ring Cell ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Free Standing ◽  
Signet Ring ◽  
Ring Cell

Signet ring cell prostatic intraepithelial neoplasia is a rare speculated variant of high-grade prostatic intraepithelial neoplasia (HGPIN). Here, we present a free-standing and isolated signet ring cell HGPIN that was not associated with invasive carcinoma on needle biopsy and demonstrated the existence of this type of HGPIN variant. The differentiation between HGPIN and intraductal carcinoma of prostate is also discussed.

Intraductal Carcinoma of the Prostate

2012 ◽  
Vol 136 (4) ◽  
pp. 418-425 ◽  
Author(s):  
Brian Robinson ◽  
Cristina Magi-Galluzzi ◽  
Ming Zhou
Keyword(s):  
Prostate Cancer ◽  
Intraepithelial Neoplasia ◽  
High Volume ◽  
Intraductal Carcinoma ◽  
Definitive Treatment ◽  
Secretory Cells ◽  
High Grade ◽  
Carcinoma Of The Prostate ◽  
Prostate Biopsies ◽  
Genetic Features

Context.—Intraductal carcinoma of the prostate (IDC-P) is a distinct clinicopathologic entity, characterized by an expansile proliferation of secretory cells within prostatic ducts and acini that demonstrate marked architectural and cytologic atypia. Intraductal carcinoma of the prostate is strongly associated with high-grade and high-volume, invasive prostate cancer and a poorer prognosis than cases without IDC-P. Objective.—To review the historic perspectives, pathologic and genetic features, diagnostic criteria and differential diagnoses, and the clinical significance of IDC-P. Data Sources.—Relevant studies indexed in PubMed. Conclusions.—It is critical to recognize IDC-P, especially in prostate biopsies in which the clinical implications of IDC-P are greatest. Morphologic criteria have been proposed to distinguish IDC-P from several other lesions with similar histologic appearance such as high-grade prostatic intraepithelial neoplasia, invasive cribriform prostate cancer, and urothelial carcinoma involving the prostate. Intraductal carcinoma of the prostate is an uncommon finding in prostate biopsies, and it is even rarer as an isolated finding without concomitant prostate cancer in biopsies. However, patients with isolated IDC-P in biopsies are recommended for either definitive treatment or immediate repeat biopsy.

A Proposal on the Identification, Histologic Reporting, and Implications of Intraductal Prostatic Carcinoma

2007 ◽  
Vol 131 (7) ◽  
pp. 1103-1109
Author(s):  
Ronald J. Cohen ◽  
Thomas M. Wheeler ◽  
Helmut Bonkhoff ◽  
Mark A. Rubin
Keyword(s):  
Diagnostic Criteria ◽  
Prostate Carcinoma ◽  
Ductal Carcinoma ◽  
Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
Published Data ◽  
Grading System ◽  
Basal Cells ◽  
Carcinoma Of The Prostate ◽  
Gleason Pattern

Abstract Context.—Prostatic adenocarcinoma growing within acinar-ductal spaces (intraductal carcinoma) in contrast to high-grade prostatic intraepithelial neoplasia (HG-PIN) impacts negatively on patient outcome. There is currently no generally accepted definition of this lesion nor is it classified in the current prostate cancer grading system (Gleason). Objective.—To define intraductal carcinoma of the prostate (IDC-P) with major and minor diagnostic criteria that clearly separate it from HG-PIN. The implications of such a lesion are discussed with proposals to incorporate this entity into the Gleason grading system. Data Sources.—We reviewed all published data referring to intraductal spread of prostate carcinoma. Articles discussing endometrial, endometrioid, and ductal carcinoma are included. Conclusions.—Intraductal carcinoma of the prostate as defined by major criteria that include enlarged gland structures, neoplastic cells spanning the gland lumen, central comedonecrosis, and further supported by minor diagnostic criteria including molecular biological markers, separate this entity from HG-PIN. Despite its perimeter basal cells, IDC-P should be interpreted as biologically equivalent to Gleason pattern 4 or 5 adenocarcinoma. Several hypotheses are proposed as to the evolution of IDC-P, which is almost always a late event in prostate carcinoma progression. Diagnosis of IDC-P on needle biopsy should prompt therapeutic intervention rather than surveillance or repeat biopsy, as is the case for HG-PIN.

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