scholarly journals Merkel cell carcinoma of lymph node with unknown primary has a significantly lower association with Merkel cell polyomavirus than its cutaneous counterpart

2014 ◽  
Vol 27 (9) ◽  
pp. 1182-1192 ◽  
Author(s):  
Zenggang Pan ◽  
Yuan-Yuan Chen ◽  
Xiaojun Wu ◽  
Vijay Trisal ◽  
Sharon P Wilczynski ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell Polyomavirus ◽  
Unknown Primary ◽  
Merkel Cell

Is Merkel Cell Carcinoma of Lymph Node Actually Metastatic Cutaneous Merkel Cell Carcinoma?

2020 ◽  
Vol 154 (3) ◽  
pp. 369-380
Author(s):  
Lauren E B Lawrence ◽  
Atif Saleem ◽  
Malaya K Sahoo ◽  
Susanna K Tan ◽  
Benjamin A Pinsky ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Unknown Primary ◽  
Merkel Cell ◽  
Mutational Signature ◽  
Panel Methods ◽  
Whole Exome ◽  
Primary Lymph Node

Abstract Objectives The possibility of a so-called primary lymph node neuroendocrine carcinoma has been described in the literature. Here we evaluate cases fitting such a diagnosis and find that the cases demonstrate a convincing and pervasive pattern consistent with metastatic Merkel cell carcinoma. Methods Six cases of primary lymph node Merkel cell carcinoma and one case of metastatic neuroendocrine carcinoma at a bony site, all with unknown primary, were sequenced using a combination of whole-exome and targeted panel methods. Sequencing results were analyzed for the presence of an ultraviolet (UV) mutational signature or off-target detection of Merkel cell polyomavirus (MCPyV). Results Four of six primary lymph node cases were positive for a UV mutational signature, with the remaining two cases positive for off-target alignment of MCPyV. One case of neuroendocrine carcinoma occurring at a bony site was also positive for a UV mutational signature. Conclusions We find no evidence to corroborate the existence of so-called primary Merkel cell carcinoma of lymph node.

Merkel cell carcinoma of the inguinal lymph node with an unknown primary site

2009 ◽  
Vol 36 (3) ◽  
pp. 170-173 ◽  
Author(s):  
Eun Jung KIM ◽  
Hei Sung KIM ◽  
Hyung Ok KIM ◽  
Chan Kwon JUNG ◽  
Yoon-Ho KO ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Inguinal Lymph Node ◽  
Primary Site ◽  
Unknown Primary ◽  
Merkel Cell ◽  
Unknown Primary Site

Lymph Node Metastases of Merkel Cell Carcinoma from Unknown Primary Site: Report of Three Cases

2008 ◽  
Vol 94 (5) ◽  
pp. 758-761 ◽  
Author(s):  
Luigi De Cicco ◽  
Andrea Vavassori ◽  
Barbara A Jereczek-Fossa ◽  
Giancarlo Pruneri ◽  
Gianpiero Catalano ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Lymph Node Metastases ◽  
Primary Site ◽  
Unknown Primary ◽  
Merkel Cell ◽  
Unknown Primary Site ◽  
Node Metastases

scholarly journals Parotid gland metastasis in Merkel cell carcinoma of the head and neck: A series of 14 cases

2016 ◽  
Vol 95 (9) ◽  
pp. 398-403 ◽  
Author(s):  
Kristine E. Day ◽  
William R. Carroll ◽  
Eben L. Rosenthal
Keyword(s):  
Lymph Node ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Dissection ◽  
Merkel Cell Carcinoma ◽  
Unknown Primary ◽  
Mortality Data ◽  
Merkel Cell

Merkel cell carcinoma (MCC) is a rare cutaneous cancer of neuroendocrine cell origin that occurs frequently on the head and neck. With a high incidence of local recurrence and regional and distant metastasis, it carries a poor prognosis. We performed a retrospective study to determine the prognostic implications of parotid gland metastasis in MCC of the head and neck. Our study population was made up of 14 patients—13 men and 1 woman, aged 62 to 87 years (mean: 75.9)—who underwent a parotidectomy for the diagnosis of MCC over a period of 10 years and 9 months. Ten patients had a primary skin lesion of the head and neck and 4 presented with a parotid mass and an unknown primary. In all, 13 of the 14 patients were found to have parotid involvement—either a direct extension of MCC into the gland or a positive intraparotid lymph node; some patients had both. All patients underwent tumor excision, and 10 underwent neck dissection. Eleven patients received adjuvant radiotherapy; none received adjuvant chemotherapy. Of the 10 patients who underwent a neck dissection, 6 were found to have a cervical lymph node metastasis on pathologic examination. Follow-up ranged from 1.3 to 39.2 months (mean: 12.4). Three patients were lost to follow-up shortly after surgery, although some information was available on 2 of them. At the final follow-up, mortality data were available on 12 patients; of these, 11 had died. The lone survivor was the patient without a parotid metastasis. Among those known to have died, survival ranged from 1.6 to 49.2 months (mean: 16.0). We conclude that parotid metastasis in patients with MCC of the head and neck is associated with a dismal survival rate that is even worse than the poor survival associated with cervical node involvement.

Sign in / Sign up

Export Citation Format

Share Document