scholarly journals Inhibition of ZEB1 by miR-200 characterizes Helicobacter pylori-positive gastric diffuse large B-cell lymphoma with a less aggressive behavior

2014 ◽  
Vol 27 (8) ◽  
pp. 1116-1125 ◽  
Author(s):  
Wei-Ting Huang ◽  
Sung-Hsin Kuo ◽  
Ann-Lii Cheng ◽  
Chung-Wu Lin
Keyword(s):  
Helicobacter Pylori ◽  
Aggressive Behavior ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Gastric Diffuse Large B-cell Lymphoma Cured with Helicobacter pylori Eradication Regardless of Whether it Contains Features of MALT Lymphoma

2014 ◽  
Vol 53 (7) ◽  
pp. 695-698 ◽  
Author(s):  
Kei Mitsuhashi ◽  
Kentaro Yamashita ◽  
Akira Goto ◽  
Takeya Adachi ◽  
Yoshihiro Kondo ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
B Cell ◽  
Malt Lymphoma ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Helicobacter Pylori Eradication ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Overexpression of B cell–activating factor of TNF family (BAFF) is associated with Helicobacter pylori–independent growth of gastric diffuse large B-cell lymphoma with histologic evidence of MALT lymphoma

Blood ◽  
2008 ◽  
Vol 112 (7) ◽  
pp. 2927-2934 ◽  
Author(s):  
Sung-Hsin Kuo ◽  
Pei-Yen Yeh ◽  
Li-Tzong Chen ◽  
Ming-Shiang Wu ◽  
Chung-Wu Lin ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
B Cell ◽  
Nuclear Translocation ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Histologic Evidence ◽  
Nuclear Expression ◽  
B Cell Activating Factor ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract We have recently demonstrated that nuclear expression of BCL10 predicts Helicobacter pylori (HP) independence of early-stage gastric diffuse large B-cell lymphoma (DLBCL) with histologic evidence of mucosa-associated lymphoid tissue (MALT). In this study, we examined the role of B cell–activating factor of TNF family (BAFF) in mediating BCL10 nuclear translocation and HP independence of gastric DLBCL (MALT). We used immunohistochemistry and immunoblotting to measure the expression of BAFF, pAKT, BCL3, BCL10, and NF-κB. Transactivity of NF-κB was measured by electromobility shift assay. In lymphoma samples from 26 patients with gastric DLBCL (MALT), we detected aberrant expression of BAFF in 7 of 10 (70%) HP-independent and in 3 of 16 (18.8%) HP-dependent cases (P = .015). BAFF overexpression was associated with pAKT expression (P = .032), and nuclear expression of BCL3 (P = .014), BCL10 (P = .015), and NF-κB (P = .004). In B-cell lymphoma Pfeiffer cells, BAFF activated NF-κB and AKT; the activated NF-κB up-regulated BCL10, and the activated AKT caused formation of BCL10/BCL3 complexes that translocated to the nucleus. Inhibition of AKT by LY294002 (a PI3K inhibitor) blocked BCL10 nuclear translocation, NF-κB transactivity, and BAFF expression. Our results indicate that autocrine BAFF signal transduction pathways may contribute to HP-independent growth of gastric DLBCL (MALT).

Regression of primary gastric diffuse large B-cell lymphoma after eradication of Helicobacter pylori

2001 ◽  
Vol 54 (5) ◽  
pp. 643-645 ◽  
Author(s):  
Mitsushige Sugimoto ◽  
Masayoshi Kajimura ◽  
Yoshihiko Sato ◽  
Hiroyuki Hanai ◽  
Eizo Kaneko ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Localized Gastric Diffuse Large B Cell Lymphoma Successfully Treated with Helicobacter Pylori Eradication.

2010 ◽  
Vol 99 (2) ◽  
pp. 334-336
Author(s):  
Hidenari Inoue ◽  
Moegi Takahashi ◽  
Yoshihiro Umezawa ◽  
Yousuke Nakamura ◽  
Shigeo Kawai ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Helicobacter Pylori Eradication ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Prognostic significance of helicobacter pylori-infection in gastric diffuse large B-cell lymphoma

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yuan Cheng ◽  
Yinan Xiao ◽  
Ruofan Zhou ◽  
Yi Liao ◽  
Jing Zhou ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
B Cell ◽  
Cell Lymphoma ◽  
Prognostic Significance ◽  
B Cell Lymphoma ◽  
Helicobacter Pylori Infection ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Progression of Primary Gastric Diffuse Large B-Cell Lymphoma after Helicobacter pylori Eradication

2020 ◽  
Vol 14 (3) ◽  
pp. 534-539
Author(s):  
Makoto Saito ◽  
Akio Mori ◽  
Reiki Ogasawara ◽  
Koh Izumiyama ◽  
Masanobu Morioka ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
B Cell ◽  
Cell Lymphoma ◽  
Treatment Strategies ◽  
B Cell Lymphoma ◽  
Endoscopic Biopsy ◽  
Chronic Active Gastritis ◽  
Large B Cell Lymphoma ◽  
H Pylori ◽  
Large B Cell

In <i>Helicobacter pylori</i>-positive, localized primary gastric diffuse large B-cell lymphoma (DLBCL), an increasing number of reports have recently been published on the effectiveness of <i>H. pylori</i> eradication (HPE). However, HPE treatment strategies for gastric DLBCL, including its indications, have yet to be examined. No detailed report has been published on a case of gastric DLBCL unsuccessfully treated by HPE. A 64-year-old female and a 70-year-old male were pathologically diagnosed with chronic active gastritis and mucosa-associated lymphoid tissue lymphoma, respectively. Both patients were positive for <i>H. pylori</i>, so HPE was employed. The disease progressed within 1 year, and both patients were pathologically diagnosed with DLBCL by endoscopic biopsy. On reviewing the first pathology slide, both patients were diagnosed with DLBCL. That is, the 2 patients had primary gastric DLBCL; however, they exhibited progressive disease after HPE. This failure of HPE treatment may be due to the initial lymphomas being multiplex ulcerative lesions. In both cases, complete remission was achieved by chemotherapy (plus radiation therapy) without recurrence for more than 3 years.

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