scholarly journals Diagnostic utility of neural stem and progenitor cell markers nestin and SOX2 in distinguishing nodal melanocytic nevi from metastatic melanomas

2012 ◽  
Vol 26 (1) ◽  
pp. 44-53 ◽  
Author(s):  
Pei-Ling Chen ◽  
Wei-Shen Chen ◽  
Jianping Li ◽  
Anne C Lind ◽  
Dongsi Lu
Keyword(s):  
Progenitor Cell ◽  
Diagnostic Utility ◽  
Cell Markers ◽  
Melanocytic Nevi

MRI features of hepatocellular carcinoma expressing progenitor cell markers

2011 ◽  
pp. n/a-n/a
Author(s):  
Hyeon Tae Jeong ◽  
Myeong-Jin Kim ◽  
Yeo-Eun Kim ◽  
Young Nyun Park ◽  
Gi Hong Choi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Progenitor Cell ◽  
Cell Markers ◽  
Mri Features

Expression of hepatic progenitor cell markers in acute cellular rejection of liver allografts-An immunohistochemical study

2018 ◽  
Vol 32 (3) ◽  
pp. e13203 ◽  
Author(s):  
Regina Cheuk-lam Lo ◽  
Kristy Kwan-shuen Chan ◽  
Carmen Oi-ning Leung ◽  
Irene Oi-lin Ng
Keyword(s):  
Progenitor Cell ◽  
Immunohistochemical Study ◽  
Acute Cellular Rejection ◽  
Hepatic Progenitor Cell ◽  
Cell Markers ◽  
Cellular Rejection

scholarly journals Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

2013 ◽  
Vol 304 (12) ◽  
pp. G1103-G1116 ◽  
Author(s):  
Shigeru B. H. Ko ◽  
Sakiko Azuma ◽  
Yukihiro Yokoyama ◽  
Akiko Yamamoto ◽  
Kazuhiro Kyokane ◽  
...  
Keyword(s):  
Autoimmune Pancreatitis ◽  
Genome Stability ◽  
Progenitor Cell ◽  
Es Cells ◽  
Embryonic Stem ◽  
Corticosteroid Treatment ◽  
Human Pancreas ◽  
Cell Markers ◽  
Telomere Elongation

We have recently identified the zinc finger and SCAN domain containing 4 (Zscan4), which is transiently expressed and regulates telomere elongation and genome stability in mouse embryonic stem (ES) cells. The aim of this study was to examine the expression of ZSCAN4 in the adult pancreas and elucidate the role of ZSCAN4 in tissue inflammation and subsequent regeneration. The expression of ZSCAN4 and other progenitor or differentiated cell markers in the human pancreas was immunohistochemically examined. Pancreas sections of alcoholic or autoimmune pancreatitis patients before and under maintenance corticosteroid treatment were used in this study. In the adult human pancreas a small number of ZSCAN4-positive (ZSCAN4+) cells are present among cells located in the islets of Langerhans, acini, ducts, and oval-shaped cells. These cells not only express differentiated cell markers for each compartment of the pancreas but also express other tissue stem/progenitor cell markers. Furthermore, the number of ZSCAN4+cells dramatically increased in patients with chronic pancreatitis, especially in the pancreatic tissues of autoimmune pancreatitis actively regenerating under corticosteroid treatment. Interestingly, a number of ZSCAN4+cells in the pancreas of autoimmune pancreatitis returned to the basal level after 1 yr of maintenance corticosteroid treatment. In conclusion, coexpression of progenitor cell markers and differentiated cell markers with ZSCAN4 in each compartment of the pancreas may indicate the presence of facultative progenitors for both exocrine and endocrine cells in the adult pancreas.

scholarly journals Expression of Progenitor Cell Markers During Expansion of Sorted Human Pancreatic Beta Cells

2005 ◽  
Vol 12 (2) ◽  
pp. 83-98 ◽  
Author(s):  
THOMAS BOUCKENOOGHE ◽  
BRIGITTE VANDEWALLE ◽  
ERICKA MOERMAN ◽  
PIERRE-MARIE DANZÉ ◽  
BRUNO LUKOWIAK ◽  
...  
Keyword(s):  
Beta Cells ◽  
Pancreatic Beta Cells ◽  
Progenitor Cell ◽  
Cell Markers

scholarly journals Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland

2012 ◽  
Vol 372 (1) ◽  
pp. 28-44 ◽  
Author(s):  
Elena García-Zaragoza ◽  
Raquel Pérez-Tavarez ◽  
Alicia Ballester ◽  
Vanesa Lafarga ◽  
Anaïs Jiménez-Reinoso ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Hedgehog Signaling ◽  
Progenitor Cell ◽  
Mouse Mammary Gland ◽  
Ciliated Cells ◽  
Cell Markers

scholarly journals Alterations in the Corneal Nerve and Stem/Progenitor Cells in Diabetes: Preventive Effects of Insulin-Like Growth Factor-1 Treatment

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Hiroki Ueno ◽  
Takaaki Hattori ◽  
Yuta Kumagai ◽  
Noboru Suzuki ◽  
Satoki Ueno ◽  
...  
Keyword(s):  
Growth Factor ◽  
Progenitor Cells ◽  
Progenitor Cell ◽  
Diabetic Group ◽  
Insulin Like Growth Factor ◽  
Diabetic Mice ◽  
Cell Markers ◽  
Igf I ◽  
Corneal Nerve

This study aimed to investigate whether corneal nerve and corneal stem/progenitor cells are altered in insulin-like growth factor-I (IGF-I-) treated individuals with diabetes. A group consisting of db/db mice with type 2 diabetes mellitus (DM) and a wild-type group were assessed by neural and corneal stem/progenitor cell markers immunostaining and real-time PCR. Moreover, the expression of corneal nerve and stem/progenitor cell markers was examined in IGF-1-treated diabetic mice. Compared with a normal cornea, swelling and stratification of the corneal epithelium were noted in db/db mice. Beta-III tubulin immunostaining revealed that the corneal subbasal plexuses in diabetic mice were thinner with fewer branches. mRNA expression levels ofHes1,Keratin15, andp75(corneal stem/progenitor cell markers) and the intensity and number of positive cells of Hes1 and Keratin19 immunostaining diminished in the diabetic corneas. Compared with the subbasal nerve density in the normal group, a decrease in the diabetic group was observed, whereas the corneal subbasal nerve density increased in IGF-1-treated diabetic group. The decreased expression of Hes1 and Keratin19 was prevented in IGF-1-treated diabetic group. Our data suggest that corneal nerve and stem/progenitor cells are altered in type 2 DM, and IGF-I treatment is capable of protecting against corneal damage in diabetes.

scholarly journals MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1

2010 ◽  
Vol 299 (1) ◽  
pp. E110-E116 ◽  
Author(s):  
Ting Zhao ◽  
Jian Li ◽  
Alex F. Chen
Keyword(s):  
Progenitor Cell ◽  
Stem Cell Markers ◽  
Endothelial Progenitor ◽  
Cell Markers ◽  
Physiological Processes ◽  
Cycle Arrest ◽  
Forkhead Box ◽  
Silent Information Regulator 1

Endothelial progenitor cells (EPCs) play an important role in angiogenesis, which is essential for numerous physiological processes as well as tumor growth. Several microRNAs (miRNAs) have been reported to be involved in angiogenesis. MiR-34a, recently reported as a tumor suppressor, has been found to target silent information regulator 1 (Sirt1), leading to cell cycle arrest or apoptosis. However, the role of miR-34a in EPC-mediated angiogenesis was unknown. The present study tested the hypothesis that miR-34a inhibits EPC-mediated angiogenesis by inducing senescence via suppressing Sirt1. Bone marrow-derived EPCs from adult male Spraque-Dawley rats were used. Results of flow cytometry showed that EPCs after 7 days of culture expressed both stem cell markers CD34 and CD133 and endothelial cell markers VEGFR-2 (flk-1) and VE-cadherin. MiR-34a was expressed in normal EPCs, and overexpression of miR-34a via its mimic transfection significantly increased its expression and impaired in vitro EPC angiogenesis. MiR-34a overexpression led to a significantly increased EPC senescence, paralleled with an ∼40% Sirt1 reduction. Furthermore, knockdown of Sirt1 by its siRNA resulted in diminished EPC angiogenesis and increased senescence. Finally, overexpression of miR-34a increased the level of Sirt1 effector-acetylated forkhead box O transcription factors 1 (FoxO1), an effect mimicked in EPCs following Sirt1 knockdown. In conclusion, miR-34a impairs EPC-mediated angiogenesis by induction of senescence via inhibiting Sirt1.

658 The identification of novel prostate stem and progenitor cell markers

2012 ◽  
Vol 11 (1) ◽  
pp. e658-e658a
Author(s):  
J.A. Ceder ◽  
M.W. Aalders ◽  
M.C.W. Voller ◽  
P.A. Abrahamsson ◽  
J.A. Schalken ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Cell Markers
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