scholarly journals Microscopic bladder neck involvement by prostate carcinoma in radical prostatectomy specimens is not a significant independent prognostic factor

2008 ◽  
Vol 22 (3) ◽  
pp. 385-392 ◽  
Author(s):  
Ming Zhou ◽  
Alwyn M Reuther ◽  
Howard S Levin ◽  
Sara M Falzarano ◽  
Emmanuel Kodjoe ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Radical Prostatectomy ◽  
Prostate Carcinoma ◽  
Bladder Neck ◽  
Independent Prognostic Factor ◽  
Significant Independent Prognostic Factor

Bladder Neck Involvement in Pathological Stage pT4 Radical Prostatectomy Specimens is Not An Independent Prognostic Factor

2002 ◽  
pp. 2011-2015 ◽  
Author(s):  
OFER YOSSEPOWITCH ◽  
KANISHKA SIRCAR ◽  
PETER T. SCARDINO ◽  
MAKOTO OHORI ◽  
MICHAEL W. KATTAN ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Radical Prostatectomy ◽  
Bladder Neck ◽  
Independent Prognostic Factor ◽  
Pathological Stage

Bladder Neck Involvement in Pathological Stage pT4 Radical Prostatectomy Specimens is Not An Independent Prognostic Factor

2002 ◽  
Vol 168 (5) ◽  
pp. 2011-2015 ◽  
Author(s):  
OFER YOSSEPOWITCH ◽  
KANISHKA SIRCAR ◽  
PETER T. SCARDINO ◽  
MAKOTO OHORI ◽  
MICHAEL W. KATTAN ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Radical Prostatectomy ◽  
Bladder Neck ◽  
Independent Prognostic Factor ◽  
Pathological Stage

scholarly journals Prognostic Significance of Molecular Upstaging of Paraffin-Embedded Sentinel Lymph Nodes in Melanoma Patients

2004 ◽  
Vol 22 (13) ◽  
pp. 2671-2680 ◽  
Author(s):  
Hiroya Takeuchi ◽  
Donald L. Morton ◽  
Christine Kuo ◽  
Roderick R. Turner ◽  
David Elashoff ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factor ◽  
Lymph Nodes ◽  
Risk Ratio ◽  
Disease Recurrence ◽  
Sentinel Lymph Nodes ◽  
Independent Prognostic Factor ◽  
Number Of Patients ◽  
Significant Independent Prognostic Factor ◽  
Melanoma Patients

PurposeDetection of micrometastases in sentinel lymph nodes (SLNs) is important for accurate staging and prognosis in melanoma patients. However, a significant number of patients with histopathology-negative SLNs subsequently develop recurrent disease. We hypothesized that a quantitative realtime reverse transcriptase polymerase chain reaction (qRT) assay using multiple specific mRNA markers could detect occult metastasis in paraffin-embedded (PE) SLNs to upstage and predict disease outcome.Patients and MethodsqRT was performed on retrospectively collected PE SLNs from 215 clinically node-negative patients who underwent lymphatic mapping and sentinel lymphadenectomy for melanoma and were followed up for at least 8 years. PE SLNs (n = 308) from these patients were sectioned and assessed by qRT for mRNA of four melanoma-associated genes: MART-1 (antigen recognized by T cells-1), MAGE-A3 (melanoma antigen gene-A3 family), GalNAc-T (β1→4-N-acetylgalactosaminyl-transferase), and Pax3 (paired-box homeotic gene transcription factor 3).ResultsFifty-three (25%) patients had histopathology-positive SLNs by hemotoxylin and eosin and/or immunohistochemistry. Of the 162 patients with histopathology-negative SLNs, 48 (30%) had nodes that expressed at least one of the four qRT markers, and these 48 patients also had a significantly increased risk of disease recurrence by a Cox proportional hazards model analysis (P < .0001; risk ratio, 7.48; 95% CI, 3.70 to 15.15). The presence of ≥ one marker in histopathology-negative SLNs was also a significant independent prognostic factor by multivariate analysis for overall survival (P = .0002; risk ratio, 11.42; 95% CI, 3.17 to 41.1).ConclusionMolecular upstaging of PE histopathology-negative SLNs by multiple-marker qRT assay is a significant independent prognostic factor for long-term disease recurrence and overall survival of patients with early-stage melanoma.

PROSTATIC APEX INVOLVEMENT IN THE SPECIMEN OF RADICAL PROSTATECTOMY IS AN INDEPENDENT PROGNOSTIC FACTOR OF TUMOR PROGRESSION

2008 ◽  
Vol 179 (4S) ◽  
pp. 495-495
Author(s):  
Lorenzo Masieri ◽  
Sergio Serni ◽  
Michele Lanciotti ◽  
Andrea Minervini ◽  
Alberto Lapini ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Radical Prostatectomy ◽  
Tumor Progression ◽  
Independent Prognostic Factor

scholarly journals Microvascular invasion is an independent prognostic factor in patients with prostate cancer treated with radical prostatectomy

2006 ◽  
Vol 32 (6) ◽  
pp. 668-677 ◽  
Author(s):  
Alberto A. Antunes ◽  
Miguel Srougi ◽  
Marcos F. Dall’oglio ◽  
Alexandre Crippa ◽  
Mario Paranhos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factor ◽  
Radical Prostatectomy ◽  
Microvascular Invasion ◽  
Independent Prognostic Factor

1032 Prostate cancer volume - an independent prognostic factor after radical prostatectomy?

2005 ◽  
Vol 4 (3) ◽  
pp. 260
Author(s):  
M. Alschibaja ◽  
W. Fritsche ◽  
J. Massmann ◽  
A. Funk ◽  
R. Hartung ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factor ◽  
Radical Prostatectomy ◽  
Independent Prognostic Factor

scholarly journals Prognostic significance of occult lymph node micrometastasis in gastric cancer: a histochemical and immunohistochemical study based on 1997 UICC TNM and 1998 JGCA classifications

2008 ◽  
Vol 21 (4) ◽  
pp. 164-169 ◽  
Author(s):  
Nelson Fausto Dell'Aquila Jr ◽  
Fábio Pinatel Lopasso ◽  
Roberto Falzoni ◽  
Kiyoshi Iriya ◽  
Joaquim Gama-Rodrigues
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Important Risk Factor ◽  
Independent Prognostic Factor ◽  
Lymph Node Status ◽  
Lymph Node Micrometastasis ◽  
Significant Independent Prognostic Factor ◽  
Risk Factor For Recurrence

BACKGROUND: Micrometastasis is a single or a cluster of malignant cells inside the lymph node that are not detected by routine histopathological sections. Micrometastasis is related to poorer prognosis in many gastric cancer studies the real significance of these cells is still controversial. AIM: To evaluate if lymph node micrometastasis is a significant independent prognostic factor and important risk factor for recurrence in gastric cancer. METHODS: A total of 1290 lymph nodes from 28 patients with gastric cancer, since 1998 until 2003, treated by radical resection (D2 and modified D3 lymphadenectomies) were studied. Three sections per lymph node were stained by Hematoxilin-Eosin, histochemical (AB-PAS) and immunohistochemical (AE1-AE3) techniques. Kaplan-Meier's survival curves and Log-rank/Cox tests were used in order to compares lymph node micrometastasis positivity, depth (pT) and location of tumor in gastric wall, histologic type, lymphatic, vascular and perineural invasion, lymph node status (pN) and stage. RESULTS: There were worse prognosis and recurrence in patients with positive lymph node micrometastasis related to vascular and perineural invasions, advanced lymph node status and advanced stages. CONCLUSION: Lymph node micrometastasis seems to be a significant independent prognostic factor and important risk factor for recurrence in gastric cancer, in a context of radical D2 lymphadenectomy

scholarly journals Promoter Hypermethylation as an Independent Prognostic Factor for Relapse in Patients with Prostate Cancer Following Radical Prostatectomy

2005 ◽  
Vol 11 (23) ◽  
pp. 8321-8325 ◽  
Author(s):  
Eli Rosenbaum ◽  
Mohammad Obaidul Hoque ◽  
Yoram Cohen ◽  
Marianna Zahurak ◽  
Mario A. Eisenberger ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Prognostic Factor ◽  
Radical Prostatectomy ◽  
Promoter Hypermethylation ◽  
Independent Prognostic Factor
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