scholarly journals Immunophenotyping of serous carcinoma of the female genital tract

2008 ◽  
Vol 21 (9) ◽  
pp. 1147-1155 ◽  
Author(s):  
Sharon Nofech-Mozes ◽  
Mahmoud A Khalifa ◽  
Nadia Ismiil ◽  
Reda S Saad ◽  
Wedad M Hanna ◽  
...  
Keyword(s):  
Genital Tract ◽  
Female Genital Tract ◽  
Serous Carcinoma ◽  
Female Genital

scholarly journals Breast metastasis from pelvic high-grade serous adenocarcinoma: a report of two cases

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Yurina Harada ◽  
Makoto Kubo ◽  
Masaya Kai ◽  
Mai Yamada ◽  
Karen Zaguirre ◽  
...  
Keyword(s):  
Genital Tract ◽  
Abdominal Cavity ◽  
Female Genital Tract ◽  
Serous Carcinoma ◽  
High Grade ◽  
Peritoneal Cancer ◽  
Cancer Tumor ◽  
Stage Ivb ◽  
The Right ◽  
Female Genital

Abstract Background Metastatic tumors to the breast reportedly account for 0.5% to 2.0% of all malignant breast diseases. Such metastatic tumors must be differentiated from primary breast cancer. Additionally, few reports have described metastases of gynecological cancers to the breast. We herein report two cases of metastasis of pelvic high-grade serous adenocarcinoma to the breast. Case presentation The first patient was a 57-year-old woman with a transverse colon obstruction. Colostomy was performed, but the cause of the obstruction was unknown. We found scattered white nodules disseminated throughout the abdominal cavity and intestinal surface. Follow-up contrast-enhanced computed tomography (CT) showed an enhanced nodule outside the right mammary gland. Core needle biopsy (CNB) of the right breast mass was conducted, and immunohistochemical staining of the mass suggested a high-grade serous carcinoma of female genital tract origin. We diagnosed the patient’s condition as breast and lymph node metastasis of a high-grade serous carcinoma of the female genital tract. After chemotherapy for stage IVB peritoneal cancer, tumor reduction surgery was performed. The second patient was a 71-year-old woman with a medical history of low anterior resection for rectal cancer at age 49, partial right thyroidectomy for follicular thyroid cancer at age 53, and left lower lung metastasis at age 57. Periodic follow-up CT showed peritoneal dissemination, cancerous peritonitis, and pericardial effusion, and the patient was considered to have a cancer of unknown primary origin. Contrast-enhanced CT showed an enhanced nodule in the left mammary gland with many enhanced nodules and peritoneal thickening in the abdominal cavity. CNB of the left breast mass was conducted, and immunohistochemical staining of the mass suggested a high-grade serous carcinoma of female genital tract origin. After chemotherapy for stage IVB peritoneal cancer, tumor reduction surgery was performed. Conclusions We experienced two rare cases of intramammary metastasis of high-grade serous carcinoma of female genital tract origin. CNB was useful for confirming the histological diagnosis of these cancers that had originated from other organs. A correct diagnosis of such breast tumors is important to ensure quick and appropriate treatment.

Uterine serous papillary carcinoma: Histopathologic changes within the female genital tract

2001 ◽  
Vol 11 (4) ◽  
pp. 283-289 ◽  
Author(s):  
L. B. Jordan ◽  
M. Abdul-Kader ◽  
A. Al-Nafussi
Keyword(s):  
Papillary Carcinoma ◽  
Fallopian Tube ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Serous Carcinoma ◽  
Tumor Spread ◽  
Histopathologic Changes ◽  
Serous Papillary Carcinoma ◽  
Female Genital

Abstract.Jordan LB, Abdul-Kader M, Al-Nafussi A. Uterine serous papillary carcinoma: Histopathologic changes within the female genital tract.The histopathologic features of 25 patients with uterine serous papillary carcinoma (USPC) were presented, with particular emphasis on the changes seen in the remaining müllerian epithelium. The mean age at presentation was 68.9 years; 52% of patients were stage III at the time of presentation and 40% died of their disease within 24 months of diagnosis. Histologic assessment revealed: 1) pure serous carcinoma in 56% of patients and mixed differentiation of serous and endometrioid in the remainder; 2) malignant epithelium reminiscent of that of USPC and akin to carcinoma in situ, frequently seen in the remaining endometrium, cervix, and, less commonly, the fallopian tube; 3) residual endometrium that, when identified (11/25 cases), was atrophic in all cases; 4) various types of cervical involvement in 17 cases (68%) ; 5) tumor within the fallopian tube in three cases (12%); and 6) carcinoma with in situ-like features in five cases (20%). In conclusion, it appears that USPC is frequently associated with malignant epithelial changes (as with carcinoma in situ) in the remaining müllerian epithelium. This finding suggests either a field change or, more likely, a transepithelial tumor spread. The latter theory is preferable, because this type of spread is frequently seen on serosal surfaces in cases of serous ovarian carcinoma. Uterine serous papillary carcinoma is, therefore, biologically more akin to its ovarian counterpart.

scholarly journals Rare Malignancies of the Female Genital Tract

2020 ◽  
Vol 15 (1) ◽  
pp. 18-23
Author(s):  
Rijuta Joshi ◽  
Gehanath Baral
Keyword(s):  
Cell Carcinoma ◽  
Granulosa Cell ◽  
Genital Tract ◽  
Single Case ◽  
Female Genital Tract ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Serous Carcinoma ◽  
Mixed Germ Cell Tumor ◽  
Female Genital

Aims: To analyze rare female genital tract malignancies. Method: This is retrospective descriptive study as a census of all rare female genital tract malignancies in two years from 2017 to 2019 at Paropakar Maternity and Women’s Hospital in Kathmandu. Data were retrieved from medical record and entered into Microsoft Excel and SPSS 16 window for analysis. Results: There were 156 cases of female genital tract malignancies including 128 common types and 28 rare types. Majority fell under 41- 50 years (n=44; 28.2%) followed by over 60 (n=41; 26.2%) and 51-60 years (n=34; 21.8%). Among ovarian tumors, the rare varieties were adult granulosa cell tumor (n=4), immature teratoma (n=3) and single case each of yolk sac tumor, dysgerminoma, malignant mixed germ cell tumor, carcinoid tumor, juvenile granulosa cell and sertoli cell tumor. There were one case each of carcinosarcoma, serous carcinoma and endometrial stromal carcinoma; two cases each of leiomyosarcoma and choriocarcinoma while there was a single case of placental site trophoblastic tumor. The rare cervical malignancies were small cell (n=2), and clear cell carcinoma (n=1). There were single cases each of basal cell carcinoma of vulva, verrucus carcinoma, fibromyxoid sarcoma of Bartholin’s gland and malignant melanoma of vagina. Conclusion: Rare female genital tract cancers were found mostly from the ovary followed by uterus; 18% of total cancers were rare types. Key words: female, genital tract, rare malignancy

Sign in / Sign up

Export Citation Format

Share Document