scholarly journals Erratum: Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice

2017 ◽  
Vol 11 (2) ◽  
pp. 579-580 ◽  
Author(s):  
S P Parihar ◽  
M Ozturk ◽  
M J Marakalala ◽  
D T Loots ◽  
R Hurdayal ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Disease Progression ◽  
Protein Kinase C Delta ◽  
Effector Functions ◽  
Kinase C ◽  
Macrophage Killing ◽  
Tuberculosis Disease

scholarly journals Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice

2017 ◽  
Vol 11 (2) ◽  
pp. 496-511 ◽  
Author(s):  
S P Parihar ◽  
M Ozturk ◽  
M J Marakalala ◽  
D T Loots ◽  
R Hurdayal ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Leishmania Major ◽  
Multidrug Resistant ◽  
Lung Pathology ◽  
Effector Functions ◽  
Kinase C ◽  
Human Participants ◽  
Functional Relevance ◽  
Macrophage Killing

Abstract We previously demonstrated that protein kinase C-δ (PKCδ) is critical for immunity against Listeria monocytogenes, Leishmania major, and Candida albicans infection in mice. However, the functional relevance of PKCδ during Mycobacterium tuberculosis (Mtb) infection is unknown. PKCδ was significantly upregulated in whole blood of patients with active tuberculosis (TB) disease. Lung proteomics further revealed that PKCδ was highly abundant in the necrotic and cavitory regions of TB granulomas in multidrug-resistant human participants. In murine Mtb infection studies, PKCδ−/− mice were highly susceptible to tuberculosis with increased mortality, weight loss, exacerbated lung pathology, uncontrolled proinflammatory cytokine responses, and increased mycobacterial burdens. Moreover, these mice displayed a significant reduction in alveolar macrophages, dendritic cells, and decreased accumulation of lipid bodies (lungs and macrophages) and serum fatty acids. Furthermore, a peptide inhibitor of PKCδ in wild-type mice mirrored lung inflammation identical to infected PKCδ−/− mice. Mechanistically, increased bacterial growth in macrophages from PKCδ−/− mice was associated with a decline in killing effector functions independent of phagosome maturation and autophagy. Taken together, these data suggest that PKCδ is a marker of inflammation during active TB disease in humans and required for optimal macrophage killing effector functions and host protection during Mtb infection in mice.

2133-P: Protein Kinase C Delta Mediates Cytokine-Induced Apoptosis in the Pancreatic Beta Cell

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2133-P
Author(s):  
NIKKI L. FARNSWORTH ◽  
ROBERT A. PISCOPIO ◽  
RICHARD K. BENNINGER
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Protein Kinase C Delta ◽  
Kinase C ◽  
P Protein ◽  
Induced Apoptosis

scholarly journals Tyrosine phosphorylation of protein kinase C-delta in response to its activation.

1994 ◽  
Vol 269 (4) ◽  
pp. 2349-2352
Author(s):  
W. Li ◽  
H. Mischak ◽  
J.C. Yu ◽  
L.M. Wang ◽  
J.F. Mushinski ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tyrosine Phosphorylation ◽  
Protein Kinase C Delta ◽  
Kinase C

scholarly journals Pulmonary Endothelial Protein Kinase C-Delta (PKCδ) Regulates Neutrophil Migration in Acute Lung Inflammation

2014 ◽  
Vol 184 (1) ◽  
pp. 200-213 ◽  
Author(s):  
Mark J. Mondrinos ◽  
Ting Zhang ◽  
Shuang Sun ◽  
Paul A. Kennedy ◽  
Devon J. King ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Lung Inflammation ◽  
Neutrophil Migration ◽  
Acute Lung Inflammation ◽  
Protein Kinase C Delta ◽  
Kinase C

Protein kinase C-delta in rat brain: Association with sensory neuronal hierarchies

1993 ◽  
Vol 331 (3) ◽  
pp. 375-388 ◽  
Author(s):  
Meredith M. Garcia ◽  
Catherine G. Cusick ◽  
Richard E. Harlan
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rat Brain ◽  
Protein Kinase C Delta ◽  
Kinase C
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