scholarly journals MMP-19 deficiency causes aggravation of colitis due to defects in innate immune cell function

2015 ◽  
Vol 9 (4) ◽  
pp. 974-985 ◽  
Author(s):  
R Brauer ◽  
J Tureckova ◽  
I Kanchev ◽  
M Khoylou ◽  
J Skarda ◽  
...  
Keyword(s):  
Cell Function ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Function

scholarly journals Developmental maturation of innate immune cell function correlates with susceptibility to central nervous system autoimmunity

2013 ◽  
Vol 43 (8) ◽  
pp. 2078-2088 ◽  
Author(s):  
Deetje Hertzenberg ◽  
Klaus Lehmann-Horn ◽  
Silke Kinzel ◽  
Veronika Husterer ◽  
Petra D. Cravens ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cell Function ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Function ◽  
Developmental Maturation

Effect of PTEN inactivating germline mutations on innate immune cell function and thyroid cancer-induced macrophages in patients with PTEN hamartoma tumor syndrome

Oncogene ◽  
2019 ◽  
Vol 38 (19) ◽  
pp. 3743-3755 ◽  
Author(s):  
Yvette J. E. Sloot ◽  
Katrin Rabold ◽  
Mihai G. Netea ◽  
Johannes W. A. Smit ◽  
Nicoline Hoogerbrugge ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Function ◽  
Immune Cell ◽  
Germline Mutations ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Function ◽  
Pten Hamartoma Tumor Syndrome

scholarly journals Thyroid hormone metabolism in innate immune cells

2017 ◽  
Vol 232 (2) ◽  
pp. R67-R81 ◽  
Author(s):  
Anne H van der Spek ◽  
Eric Fliers ◽  
Anita Boelen
Keyword(s):  
Thyroid Hormone ◽  
Immune Cells ◽  
Cellular Response ◽  
Cell Function ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Extensive Literature ◽  
Innate Immune Cells ◽  
Immune Cell Function

Thyroid hormone (TH) metabolism and thyroid status have been linked to various aspects of the immune response. There is extensive literature available on the effects of thyroid hormone on innate immune cells. However, only recently have authors begun to study the mechanisms behind these effects and the role of intracellular TH metabolism in innate immune cell function during inflammation. This review provides an overview of the molecular machinery of intracellular TH metabolism present in neutrophils, macrophages and dendritic cells and the role and effects of intracellular TH metabolism in these cells. Circulating TH levels have a profound effect on neutrophil, macrophage and dendritic cell function. In general, increased TH levels result in an amplification of the pro-inflammatory response of these cells. The mechanisms behind these effects include both genomic and non-genomic effects of TH. Besides a pro-inflammatory effect induced by extracellular TH, the cellular response to pro-inflammatory stimuli appears to be dependent on functional intracellular TH metabolism. This is illustrated by the fact that the deiodinase enzymes and in some cell types also thyroid hormone receptors appear to be crucial for adequate innate immune cell function. This overview of the literature suggests that TH metabolism plays an important role in the host defence against infection through the modulation of innate immune cell function.

Thyroid Hormone and Deiodination in Innate Immune Cells

Endocrinology ◽  
2020 ◽  
Vol 162 (1) ◽  
Author(s):  
Anne H van der Spek ◽  
Eric Fliers ◽  
Anita Boelen
Keyword(s):  
Thyroid Hormone ◽  
Immune Cells ◽  
Cell Function ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Innate Immune Cells ◽  
Immune Cell Function ◽  
Hormone Metabolism ◽  
Thyroid Hormone Metabolism

Abstract Thyroid hormone has recently been recognized as an important determinant of innate immune cell function. Highly specialized cells of the innate immune system, including neutrophils, monocytes/macrophages, and dendritic cells, are capable of identifying pathogens and initiating an inflammatory response. They can either phagocytose and kill microbes, or recruit other innate or adaptive immune cells to the site of inflammation. Innate immune cells derive from the hematopoietic lineage and are generated in the bone marrow, from where they can be recruited into the blood and tissues in the case of infection. The link between the immune and endocrine systems is increasingly well established, and recent studies have shown that innate immune cells can be seen as important thyroid hormone target cells. Tight regulation of cellular thyroid hormone availability and action is performed by thyroid hormone transporters, receptors, and the deiodinase enzymes. Innate immune cells express all these molecular elements of intracellular thyroid hormone metabolism. Interestingly, there is recent evidence for a causal relationship between cellular thyroid hormone status and innate immune cell function. This review describes the effects of modulation of intracellular thyroid hormone metabolism on innate immune cell function, specifically neutrophils, macrophages, and dendritic cells, with a special focus on the deiodinase enzymes. Although there are insufficient data at this stage for conclusions on the clinical relevance of these findings, thyroid hormone metabolism may partially determine the innate immune response and, by inference, the clinical susceptibility to infections.

scholarly journals Critical Role of Zinc Transporter (ZIP8) in Myeloid Innate Immune Cell Function and the Host Response against Bacterial Pneumonia

2021 ◽  
pp. ji2001395
Author(s):  
Sannette C. Hall ◽  
Deandra R. Smith ◽  
Shetty Ravi Dyavar ◽  
Todd A. Wyatt ◽  
Derrick R. Samuelson ◽  
...  
Keyword(s):  
Host Response ◽  
Bacterial Pneumonia ◽  
Cell Function ◽  
Immune Cell ◽  
Critical Role ◽  
Zinc Transporter ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Function

Regulatory role of periodontal ligament fibroblasts for innate immune cell function and differentiation

2012 ◽  
Vol 18 (5) ◽  
pp. 745-752 ◽  
Author(s):  
Anna Konermann ◽  
Dirk Stabenow ◽  
Percy A Knolle ◽  
Stefanie AE Held ◽  
James Deschner ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Cell Function ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Regulatory Role ◽  
Immune Cell Function ◽  
Periodontal Ligament Fibroblasts

Mo1297 Clotrimazole and Related Triarylmethane Analogues Inhibit Innate Immune Cell Function and Reduce Intestinal Inflammation

2016 ◽  
Vol 150 (4) ◽  
pp. S691
Author(s):  
Jay Thiagarajah ◽  
Michael Rufo ◽  
Jeffrey Chang ◽  
Wayne I. Lencer ◽  
Paul A. Rufo
Keyword(s):  
Cell Function ◽  
Immune Cell ◽  
Intestinal Inflammation ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Function

scholarly journals Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71634 ◽  
Author(s):  
Shyra J. Gardai ◽  
Wenxian Mao ◽  
Birgitt Schüle ◽  
Michael Babcock ◽  
Sue Schoebel ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Function ◽  
Immune Cell ◽  
Alpha Synuclein ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Function ◽  
Peripheral Biomarker

Metabolism and acetylation in innate immune cell function and fate

2016 ◽  
Vol 28 (5) ◽  
pp. 408-416 ◽  
Author(s):  
Alanna M. Cameron ◽  
Simon J. Lawless ◽  
Edward J. Pearce
Keyword(s):  
Cell Function ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cell ◽  
Immune Cell Function
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