scholarly journals New targets for mucosal healing and therapy in inflammatory bowel diseases

2013 ◽  
Vol 7 (1) ◽  
pp. 6-19 ◽  
Author(s):  
M F Neurath
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Mucosal Healing ◽  
New Targets ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Vedolizumab for the treatment of inflammatory bowel diseases: from symptomatic control to mucosal healing

Immunotherapy ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 565-575
Author(s):  
Ferdinando D’Amico ◽  
Gionata Fiorino ◽  
Laurent Peyrin-Biroulet ◽  
Silvio Danese
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Mucosal Healing ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Symptomatic Control

scholarly journals Resolution of Inflammation and Gut Repair in IBD: Translational Steps Towards Complete Mucosal Healing

2020 ◽  
Vol 26 (8) ◽  
pp. 1131-1143 ◽  
Author(s):  
Gwo-tzer Ho ◽  
Jennifer A Cartwright ◽  
Emily J Thompson ◽  
Calum C Bain ◽  
Adriano G Rossi
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Inflammatory Cell ◽  
Mucosal Healing ◽  
Treatment Target ◽  
Resolution Of Inflammation ◽  
Epithelial Repair ◽  
New Knowledge ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Macrophage Populations

Abstract Despite significant recent therapeutic advances, complete mucosal healing remains a difficult treatment target for many patients with inflammatory bowel diseases (IBD) to achieve. Our review focuses on the translational concept of promoting resolution of inflammation and repair as a necessary adjunctive step to reach this goal. We explore the roles of inflammatory cell apoptosis and efferocytosis to promote resolution, the new knowledge of gut monocyte-macrophage populations and their secreted prorepair mediators, and the processes of gut epithelial repair and regeneration to bridge this gap. We discuss the need and rationale for this vision and the tangible steps toward integrating proresolution therapies in IBD.

Mucosal Healing in Inflammatory Bowel Diseases

2015 ◽  
Vol 21 (1) ◽  
pp. 198-207 ◽  
Author(s):  
Annaïg Lan ◽  
François Blachier ◽  
Robert Benamouzig ◽  
Martin Beaumont ◽  
Christophe Barrat ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Mucosal Healing ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Noninvasive evaluation of mucosal healing in inflammatory bowel diseases

2012 ◽  
Vol 6 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Jun Kato ◽  
Sakiko Hiraoka ◽  
Asuka Nakarai ◽  
Masao Ichinose
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Mucosal Healing ◽  
Noninvasive Evaluation ◽  
Bowel Diseases ◽  
Inflammatory Bowel

scholarly journals Histological Hallmarks of Mucosal Healing in Inflammatory Bowel Diseases in the Era of Monoclonal Antibodies Therapy: New Insights and Perspectives

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1570
Author(s):  
Gerardo Cazzato ◽  
Anna Colagrande ◽  
Valeria Andriola ◽  
Teresa Lettini ◽  
Sebastiano Cicco ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Natural History ◽  
Inflammatory Bowel Diseases ◽  
Careful Analysis ◽  
Mucosal Healing ◽  
Level Of Evidence ◽  
Clinical Endpoints ◽  
Bowel Diseases ◽  
History Of ◽  
Inflammatory Bowel

Background: Chronic inflammatory bowel diseases (IBDs) are gaining increasing attention, both because they can severely reduce the quantity and quality of life, and because the advent of monoclonal antibodies has profoundly changed the natural history of these diseases. In recent years, the concept of mucosal healing has assumed a certain importance, and there are more and more clinical and pharmacological trials that consider this parameter among their endpoints, so much so that it may soon be included among the desirable clinical outcomes of patients with IBD. Methods: We performed a literature review of the Pubmed, Medline, and Web of Science (WoS) databases. Results: We selected 88 articles and then removed 6 duplicates; the final sample after accurate application of the inclusion criteria numbered 73 articles, with a level of evidence rating of three or four, according to Oxfords Evidence-based medicine. Our aim was to study the histological impact of monoclonal antibody therapies on mucosal healing, taking into consideration the few studies present in the literature. To perform this review, we compared studies that examined patients with Crohn’s disease (CD) and/or ulcerative colitis (UC) undergoing monoclonal therapy versus patients undergoing other non-biological therapies (PICO statements). Conclusions: We try to delineate how monoclonal antibodies have changed the natural history of IBD, acting at the microscopic level, and we believe that a careful analysis of the histopathology and the definition of the objective criteria for “Mucosa Healing” should enable this concept to be included among the clinical endpoints of patients affected by IBD, thus contributing to a better therapeutic management of these patients.

Association Between Pharmacokinetics of Adalimumab and Mucosal Healing in Patients With Inflammatory Bowel Diseases

2014 ◽  
Vol 12 (1) ◽  
pp. 80-84.e2 ◽  
Author(s):  
Xavier Roblin ◽  
Hubert Marotte ◽  
Melanie Rinaudo ◽  
Emilie Del Tedesco ◽  
Amelie Moreau ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Mucosal Healing ◽  
Bowel Diseases ◽  
Inflammatory Bowel
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