scholarly journals Lysosomotropic agents selectively target chronic lymphocytic leukemia cells due to altered sphingolipid metabolism

Leukemia ◽  
2016 ◽  
Vol 30 (6) ◽  
pp. 1290-1300 ◽  
Author(s):  
R F Dielschneider ◽  
H Eisenstat ◽  
S Mi ◽  
J M Curtis ◽  
W Xiao ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Sphingolipid Metabolism ◽  
Lysosomotropic Agents

scholarly journals Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219

2009 ◽  
Vol 15 (11) ◽  
pp. 3760-3769 ◽  
Author(s):  
Cheng-Yu Tsai ◽  
Adrian S. Ray ◽  
Daniel B. Tumas ◽  
Michael J. Keating ◽  
Hans Reiser ◽  
...  
Keyword(s):  
Dna Repair ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Nucleotide Analogue

scholarly journals Induction of histone H1.2 cytosolic release in chronic lymphocytic leukemia cells after genotoxic and non-genotoxic treatment

Haematologica ◽  
2008 ◽  
Vol 93 (1) ◽  
pp. 75-82 ◽  
Author(s):  
E. Gine ◽  
M. Crespo ◽  
A. Muntanola ◽  
E. Calpe ◽  
M. J. Baptista ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells

A novel monoclonal antibody recognizing human thymocytes and B-cell chronic lymphocytic leukemia cells

1994 ◽  
Vol 39 (2) ◽  
pp. 137-146 ◽  
Author(s):  
P. Tassone ◽  
P. Bonelli ◽  
F. Tuccillo ◽  
H.M. Bond ◽  
M.C. Turco ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Cell Chronic Lymphocytic Leukemia

scholarly journals Chronic lymphocytic leukemia cells induce defective LFA-1–directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide

Blood ◽  
2013 ◽  
Vol 121 (14) ◽  
pp. 2704-2714 ◽  
Author(s):  
Alan G. Ramsay ◽  
Rachel Evans ◽  
Shahryar Kiaii ◽  
Lena Svensson ◽  
Nancy Hogg ◽  
...  
Keyword(s):  
T Cell ◽  
Chronic Lymphocytic Leukemia ◽  
Cell Motility ◽  
Rho Gtpase ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Key Points ◽  
Gtpase Activation ◽  
Activation Signaling

Key Points CLL cells induce defects in T-cell LFA-1–mediated migration by altering Rho GTPase activation signaling, downregulating RhoA and Rac1, and upregulating Cdc42. Lenalidomide repairs these T-cell defects by restoring normal Rho GTPase activation signaling.

The induction of p53 and WAF1/CIP1 in chronic lymphocytic leukemia cells treated with 2-chlorodeoxyadenosine

1996 ◽  
Vol 74 (3) ◽  
pp. 143-147 ◽  
Author(s):  
R. B. Gartenhaus ◽  
P. Wang ◽  
M. Hoffman ◽  
D. Janson ◽  
K. R. Rai
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells

scholarly journals Chronic lymphocytic leukemia cells display p53-dependent drug-induced Puma upregulation

Leukemia ◽  
2005 ◽  
Vol 19 (3) ◽  
pp. 427-434 ◽  
Author(s):  
W J M Mackus ◽  
A P Kater ◽  
A Grummels ◽  
L M Evers ◽  
B Hooijbrink ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Leukemia Cells ◽  
Drug Induced
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