scholarly journals The tumor microenvironment is the main source of IL-6 for plasma cell tumor development in mice

Leukemia ◽  
2014 ◽  
Vol 29 (1) ◽  
pp. 233-237 ◽  
Author(s):  
T R Rosean ◽  
V S Tompkins ◽  
A K Olivier ◽  
R Sompallae ◽  
L A Norian ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Plasma Cell ◽  
Tumor Development ◽  
Cell Tumor ◽  
Plasma Cell Tumor

scholarly journals THE INTRACELLULAR DISTRIBUTION OF GAMMA GLOBULIN IN A MOUSE PLASMA CELL TUMOR (X5563) AS REVEALED BY FLUORESCENCE AND ELECTRON MICROSCOPY

1962 ◽  
Vol 116 (4) ◽  
pp. 423-432 ◽  
Author(s):  
Richard A. Rifkind ◽  
Elliott F. Osserman ◽  
Konrad C. Hsu ◽  
Councilman Morgan
Keyword(s):  
Endoplasmic Reticulum ◽  
Plasma Cell ◽  
Secretory Protein ◽  
Cell Tumor ◽  
Secretory Process ◽  
Cytoplasmic Matrix ◽  
Mouse Plasma ◽  
Plasma Cell Tumor ◽  
Antibody Staining ◽  
Fluorescence And Electron Microscopy

Ferritin- and fluorescein-conjugated antibody staining has been applied to a study of a mouse plasma cell tumor. The presence of myeloma globulin within cisternae of the endoplasmic reticulum was observed at a stage of the secretory process when the remainder of the cytoplasm was essentially free of labeled globulin. The distribution of ferritin suggested a functional heterogeneity among units of the endoplasmic reticulum. Apparently, progressive accumulation of globulin results in distension of the endoplasmic reticulum and, occasionally, in the appearance of considerable quantities of this secretory protein in the extracisternal cytoplasmic matrix. Participation of the Golgi apparatus in the packaging and release of small quantitites of globulin seems likely. In addition, however, fragmentation of the peripheral cytoplasm with rupture of distended ergastoplasmic vesicles appeared to be another pathway whereby globulin is secreted.

Direct Myeloma Cell Invasion as One of the Major Causes of Renal Impairment In Myeloma A Pathological Analysis of Renal Findings In 41 Autopsied Cases

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 5001-5001
Author(s):  
Amane Tagashira ◽  
Junichiro Takano ◽  
Shotaro Hagiwara ◽  
Makoto Mochizuki ◽  
Hisako Endo ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Cell Invasion ◽  
Conflicts Of Interest ◽  
Myeloma Cell ◽  
Cell Tumor ◽  
Renal Diseases ◽  
Al Amyloidosis ◽  
Plasma Cell Tumor ◽  
Cast Nephropathy ◽  
Tumor Involvement

Abstract Abstract 5001 Background: Renal insufficiency is one of the main complications in myeloma patients. Various causes were reported to be responsible for renal damage. Through analysis of an autopsied cases we would show the diversity of the renal diseases in myeloma. Methods: We studied 41 autopsied myeloma cases from 1979 to 2008 at the National Center for Global Health and Medicine. The kidneys were evaluated by light microscopy using hematoxilin-eosin-stained sections, as well as Congo-red stain when amyloidosis was suspected. Results: There were 21 men and 20 women. Mean age at autopsy was 64.5 years old. The most common lesion was cast nephropathy (41.5%). The giant cell invasion was found in 35.3% of patients with cast nephropathy. Plasma cell tumor involvement was detected in 29.3% of all 41 autopsied cases. Fourteen per cent of cases had both cast nephropathy and plasma cell tumor involvement. In 75.6% of the patients, arteriosclerosis was found. In addition, 32% of the patients had the glomerular sclerosis which involved more than 20% of the glomerulus. Other findings include acute tubular necrosis (31.7%), AL-amyloidosis (19.5%), renal calcification (17.1%), bacterial and fungal infection (7.7%), micro thrombo-embolism (7.7%), mesangial proliferation (4.9%). At least one of above findings were detected in all cases and combined findings were detected in 65.9% cases. Conclusion: We evaluated the renal manifestations in 41 autopsied cases in detail. In all cases, at least one pathological finding was detected. Cast nephropathy was the most common renal manifestation. However, direct myeloma cell invasion was found in 29.3% and combined pathologic findings were common. Disclosures: No relevant conflicts of interest to declare.

scholarly journals The bone marrow of multiple myeloma patients contains B cell populations at different stages of differentiation that are clonally related to the malignant plasma cell.

1993 ◽  
Vol 178 (3) ◽  
pp. 1023-1031 ◽  
Author(s):  
D Billadeau ◽  
G Ahmann ◽  
P Greipp ◽  
B Van Ness
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
B Cell ◽  
Plasma Cell ◽  
Polymerase Chain Reaction Amplification ◽  
Cell Tumor ◽  
Growth Fraction ◽  
Cell Populations ◽  
Chain Gene ◽  
Plasma Cell Tumor

One of the distinguishing features of multiple myeloma (MM) is the proliferation of a clonal plasma cell population in the bone marrow (BM). It is of particular interest that the tumor plasma cells appear to be restricted to the microenvironment of the BM and are rarely detected in the peripheral system, yet the disease is found widely disseminated throughout the axial skeleton. Furthermore, isolation of MM tumor cell lines has proven to be quite problematic due to their slow growth rate. These observations have instigated the search for earlier cells in the B cell lineage that are clonally related to the plasma cell tumor and that may represent the growth fraction of the tumor. We used allele-specific oligonucleotides (ASO) derived from the third complementarity determining region of the rearranged tumor immunoglobulin heavy chain gene to detect isotypes clonally related to the plasma cell tumor. By reverse transcribing RNA from the BM with a panel of CH primers (mu, delta, alpha, and gamma), followed by ASO-polymerase chain reaction amplification, we demonstrate the existence of preswitch isotype species that are clonally related to the myeloma tumor. Furthermore, we show that separation of the BM cells into CD45+ and CD38+ cell populations results in a lineage-specific expression of the clonally related RNA molecules, with the C mu and C delta in the CD45+, and C gamma in the CD38+ population. Interestingly, clonally related C alpha transcripts are also derived from the CD45+ fraction. These results confirm the presence of B cell populations clonally related to the plasma cell tumor and are consistent with models that propose the existence of myeloma precursors.

PLASMA-CELL TUMOR OF THE BREAST WITH METASTASES

1934 ◽  
Vol 100 (2) ◽  
pp. 392-394 ◽  
Author(s):  
CONDICT W. CUTLER
Keyword(s):  
Plasma Cell ◽  
Cell Tumor ◽  
Plasma Cell Tumor
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