MYD88 (L265P) mutation is an independent prognostic factor for outcome in patients with diffuse large B-cell lymphoma

Leukemia ◽  
2014 ◽  
Vol 28 (10) ◽  
pp. 2104-2106 ◽  
Author(s):  
C Fernández-Rodríguez ◽  
B Bellosillo ◽  
M García-García ◽  
B Sánchez-González ◽  
E Gimeno ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Independent Prognostic Factor ◽  
Large B Cell Lymphoma ◽  
Myd88 L265p Mutation ◽  
Myd88 L265p ◽  
Large B Cell

MYD88 L265P mutation detected by digital PCR as a prognostic factor in patients with diffuse large B-cell lymphoma in rituximab era

2020 ◽  
Vol 97 ◽  
pp. 106426
Author(s):  
Noriko Nishimura ◽  
Kengo Takeuchi ◽  
Reimi Asaka ◽  
Naoko Tuyama ◽  
Norihito Inoue ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Digital Pcr ◽  
Large B Cell Lymphoma ◽  
Myd88 L265p Mutation ◽  
Myd88 L265p ◽  
Large B Cell

scholarly journals Global hypomethylation is an independent prognostic factor in diffuse large B cell lymphoma

2017 ◽  
Vol 92 (7) ◽  
pp. 689-694 ◽  
Author(s):  
Eileen Wedge ◽  
Jakob Werner Hansen ◽  
Christian Garde ◽  
Fazila Asmar ◽  
Dorte Tholstrup ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Independent Prognostic Factor ◽  
Large B Cell Lymphoma ◽  
Global Hypomethylation ◽  
Large B Cell

scholarly journals Prognostic value of MYD88 L265P mutation in diffuse large B cell lymphoma via droplet digital PCR

2020 ◽  
Vol 22 (2) ◽  
pp. 1243-1256 ◽  
Author(s):  
Jing Niu ◽  
Zhiping Ma ◽  
Aijiang Nuerlan ◽  
Sijing Li ◽  
Wenli Cui ◽  
...  
Keyword(s):  
B Cell ◽  
Prognostic Value ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Digital Pcr ◽  
Droplet Digital Pcr ◽  
Large B Cell Lymphoma ◽  
Myd88 L265p Mutation ◽  
Myd88 L265p ◽  
Large B Cell

scholarly journals DLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation

2020 ◽  
Author(s):  
Xuemin Xue ◽  
Wenting Huang ◽  
Tian Qiu ◽  
Lei Guo ◽  
Jianming Ying ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Driver Genes ◽  
Large B Cell Lymphoma ◽  
Unfavorable Clinical Outcome ◽  
Myd88 L265p Mutation ◽  
Myd88 L265p ◽  
Large B Cell

Abstract Background: Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal large B-cell lymphoma(PMBCL). However, their CNA-based profile and clinical impact still remain unclear. Methods: Multiplex ligation-dependent probe amplification were employed to investigate the prevalence of JAK2/PD-L2 amplification in DLBCL and their CNA-based pattern of driver genes. The clinical outcome and characteristics were also analyzed. Results: Using unsupervised hierarchical clustering, a small group of DLBCL (10.5%, 8/76) was clustered together with PMBCL as Cluster_2, demonstrating amplification of JAK2 (100%,8/8) and PD-L2 (75.0%,6/8). This subgroups of DLBCL demonstrated significant higher expression of PD-L1 than those with MYD88 L265P mutation(p=0.024). And they exhibited dismal OS and PFS as compared with DLBCL_others(p=0.003 and 0.001, respectively), which is similar to DLBCL with MYD88 L265P mutation. Conclusions: DLBCL with amplification of JAK2/PD-L2 exhibits CNA pattern that is similar to PMBCL, and demonstrates unfavorable clinical outcome that resembles those with MYD88 L265P mutation. It is essential to identify this subgroup of DLBCL who may acquire more benefits from the JAK2 and PD-L1 signaling inhibition.

scholarly journals Increased MYC copy number is an independent prognostic factor in patients with diffuse large B-cell lymphoma

2017 ◽  
Vol 30 (12) ◽  
pp. 1688-1697 ◽  
Author(s):  
Andrés E Quesada ◽  
L Jeffrey Medeiros ◽  
Parth A Desai ◽  
Pei Lin ◽  
Jason R Westin ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
B Cell ◽  
Copy Number ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Independent Prognostic Factor ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Sarcopenia is an independent prognostic factor in elderly patients with diffuse large B-cell lymphoma treated with immunochemotherapy

2013 ◽  
Vol 55 (4) ◽  
pp. 817-823 ◽  
Author(s):  
Hélène Lanic ◽  
Jerôme Kraut-Tauzia ◽  
Romain Modzelewski ◽  
Florian Clatot ◽  
Sylvain Mareschal ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Elderly Patients ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Independent Prognostic Factor ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Expression and Prognosis of MYD88 L265p Mutation in Diffuse Large B-Cell Lymphoma

2020 ◽  
Vol 10 (04) ◽  
pp. 133-139
Author(s):  
Yiming Zhao ◽  
Rui Zhang ◽  
Ling Ge ◽  
Wei Qian ◽  
Fengbo Jin ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Myd88 L265p Mutation ◽  
Myd88 L265p ◽  
Large B Cell
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