scholarly journals Bone marrow stromal cell-fueled multiple myeloma growth and osteoclastogenesis are sustained by protein kinase CK2

Leukemia ◽  
2014 ◽  
Vol 28 (10) ◽  
pp. 2094-2097 ◽  
Author(s):  
S Manni ◽  
D Toscani ◽  
E Mandato ◽  
A Brancalion ◽  
L Quotti Tubi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Protein Kinase ◽  
Protein Kinase Ck2 ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Marrow Stromal Cell ◽  
Kinase Ck2

The IL-6 receptor antagonist SANT-7 overcomes bone marrow stromal cell-mediated drug resistance of multiple myeloma cells

2001 ◽  
Vol 93 (5) ◽  
pp. 674-680 ◽  
Author(s):  
Dirk H�nemann ◽  
Manik Chatterjee ◽  
Rocco Savino ◽  
Kurt Bommert ◽  
Renate Burger ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Drug Resistance ◽  
Receptor Antagonist ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Myeloma Cells ◽  
Marrow Stromal Cell

scholarly journals Induction of multiple myeloma bone marrow stromal cell apoptosis by inhibiting extracellular vesicle miR-10a secretion

2019 ◽  
Vol 3 (21) ◽  
pp. 3228-3240 ◽  
Author(s):  
Tomohiro Umezu ◽  
Satoshi Imanishi ◽  
Seiichiro Yoshizawa ◽  
Chiaki Kawana ◽  
Junko H. Ohyashiki ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Cell Apoptosis ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Extracellular Vesicle ◽  
Marrow Stromal Cell ◽  
Key Points

Key Points Inhibition of EV release resulted in accumulation of cellular miR-10a and enhanced apoptosis of BMSCs derived from patients with MM. Inhibition of miR-10a–enriched EVs from BMSCs also inhibited proliferation of MM cells.

scholarly journals Bone marrow microenvironment–derived signals induce Mcl-1 dependence in multiple myeloma

Blood ◽  
2017 ◽  
Vol 129 (14) ◽  
pp. 1969-1979 ◽  
Author(s):  
Vikas A. Gupta ◽  
Shannon M. Matulis ◽  
Jason E. Conage-Pough ◽  
Ajay K. Nooka ◽  
Jonathan L. Kaufman ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Signaling Pathways ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Bone Marrow Microenvironment ◽  
Marrow Stromal Cell ◽  
Key Points

Key Points Bone marrow stromal cell–derived IL-6 induces Mcl-1 dependence through transcriptional and posttranslational changes in the Bcl-2 family. Blocking IL-6 signaling pathways sensitizes myeloma to inhibitors of Bcl-2 and Bcl-2/Bcl-xL.

Bone marrow stromal cell–derived exosomes as communicators in drug resistance in multiple myeloma cells

Blood ◽  
2014 ◽  
Vol 124 (4) ◽  
pp. 555-566 ◽  
Author(s):  
Jinheng Wang ◽  
An Hendrix ◽  
Sophie Hernot ◽  
Miguel Lemaire ◽  
Elke De Bruyne ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Cell Proliferation ◽  
Drug Resistance ◽  
Stromal Cell ◽  
Bone Marrow Stromal Cell ◽  
Myeloma Cells ◽  
Marrow Stromal Cell ◽  
Key Points

Key Points BMSCs and MM cells mutually communicate through exosomes, which carry selective cytokines. BMSC-derived exosomes favor MM cell proliferation, migration, and survival and induce drug resistance to bortezomib.

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